scholarly journals Metabolic Status of “Metabolically Normal Obese” Subjects or “MNO”

Author(s):  
Ghouini A

Metabolic status is dependent on the anthropometric profile; indeed, many obese subjects are "metabolically normal" (MNO or Metabolically Normal Obese) while conversely, other obese or even non-obese subjects are "metabolically abnormal". The topography and the function of the fatty deposits seem to play a determining role in explaining this apparent paradox. In this study are examined the carbohydrate, lipid and liver balance of overweight subjects according to their anthropometric indices. It turns out that generalized obesity where the distribution of fat is diffuse as well as gynoid obesity (gluteo-femoral) are correlated at an almost normal metabolic profile compared to android obesity characterized by the metabolic dysregulations.

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mithun Sharma ◽  
Anand Kulkarni ◽  
Pramod Kumar ◽  
Vijay Bhaskar Nori ◽  
Nitin Jagtap ◽  
...  

An amendment to this paper has been published and can be accessed via a link at the top of the paper.


2019 ◽  
Vol 104 (12) ◽  
pp. 5780-5790 ◽  
Author(s):  
Francisco J Amaro-Gahete ◽  
Guillermo Sanchez-Delgado ◽  
Ignacio Ara ◽  
Jonatan R. Ruiz

Abstract Context We examined whether obese individuals have a reduced maximal fat oxidation (MFO) and the intensity that elicit MFO (Fatmax) compared with normal weight and overweight persons, taking into account their level of cardiorespiratory fitness. Methods The study subjects were 138 sedentary adults (87 women) aged 30.1 ± 13.6 years. Based on their body mass index, subjects were categorized as being of normal weight (n = 66), overweight (n = 48), or obese (n = 24). MFO and Fatmax were determined for all subjects by indirect calorimetry, using a walking graded exercise test. MFO was expressed in absolute terms (g/min) and relative to whole-body lean mass (mg/kgleanmass/min). Cardiorespiratory fitness was assessed via a maximal treadmill test. Results No differences in absolute MFO and Fatmax values were seen between the obese, normal weight, and overweight subjects (all P > 0.2), although after adjusting for cardiorespiratory fitness, the obese subjects returned significantly higher values than did their normal weight and overweight counterparts (all P < 0.03). However, when expressed with respect to lean mass, the MFO of the normal weight subjects was significantly greater than that of the overweight and obese subjects, independent of age, sex, or cardiorespiratory fitness. Conclusions Obese individuals have higher absolute MFO values when cardiorespiratory fitness is taken into account, but when expressed with respect to lean mass, normal weight individuals show a greater capacity to oxidize fat during exercise per unit of metabolically active tissue independent of age, sex, or cardiorespiratory fitness. These findings suggest that obese individuals may suffer from metabolic inflexibility during exercise.


2014 ◽  
Vol 82 (5) ◽  
pp. 445-449 ◽  
Author(s):  
Setila Dalili ◽  
Hamid Mohammadi ◽  
Seyed Mahmood Rezvany ◽  
Arsalan Dadashi ◽  
Mohammad Hassan Novin ◽  
...  

2013 ◽  
Vol 29 (6) ◽  
pp. 705-711 ◽  
Author(s):  
Stefan Schmid ◽  
Stéphane Armand ◽  
Zoltan Pataky ◽  
Alain Golay ◽  
Lara Allet

An important prerequisite to carry out daily activities is the sit-to-stand movement. However, in obese people, this movement is characterized by altered biomechanics, which might lead to daily life activity impairments. The aim of this study was to investigate whether there are differences in kinetic and kinematic variables between three different BMI categories when performing a specific sit-to-stand test. Thirty-six adult women (BMI = 17–45 kg/m2) performed the sit-to stand test five times consecutively and as quickly as possible. Analyses of variance were used to determine differences between three BMI groups (normal or overweight: BMI < 30 kg/m2; obese: 30 ≤ BMI < 35; severely obese: BMI ≥ 35). Peak and mean vertical sacrum velocity indicated a decrease in severely obese subjects. Obese and severely obese individuals did not show higher fatigue over the five consecutive movements. Peak force and rate of force development decreased in normal or overweight subjects. The ability to successfully complete the test decreased with a higher BMI, probably due to a reduced ability to rapidly generate a high force.


2013 ◽  
Vol 24 (5) ◽  
pp. 777-782 ◽  
Author(s):  
Runa Zazai ◽  
Britta Wilms ◽  
Barbara Ernst ◽  
Martin Thurnheer ◽  
Bernd Schultes

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Yunjuan Gu ◽  
Haoyong Yu ◽  
Yuehua Li ◽  
Xiaojing Ma ◽  
Junxi Lu ◽  
...  

Aim. To investigate the effects of weight loss during an 8-week very low carbohydrate diet (VLCD) on improvement of metabolic parameters, adipose distribution and body composition, and insulin resistance and sensitivity in Chinese obese subjects.Methods. Fifty-three healthy obese volunteers were given an 8-week VLCD. The outcomes were changes in anthropometry, body composition, metabolic profile, abdominal fat distribution, liver fat percent (LFP), and insulin resistance and sensitivity.Results. A total of 46 (86.8%) obese subjects completed the study. The VLCD caused a weight loss of−8.7±0.6 kg (mean ± standard error (SE),P<0.0001) combined with a significant improvement of metabolic profile. In both male and female, nonesterified fatty acid (NEFA) significantly decreased (−166.2±47.6 μmol/L,P=0.001) andβ-hydroxybutyric acid (BHA) increased (0.15±0.06 mmol/L,P=0.004) after eight weeks of VLCD intervention. The significant reductions in subcutaneous fat area (SFA), visceral fat area (VFA), and LFP were−66.5±7.9 cm2,−35.3±3.9 cm2, and−16.4±2.4%, respectively (allPvaluesP<0.0001). HOMA IR and HOMAβsignificantly decreased while whole body insulin sensitivity index (WBISI) increased (allPvaluesP<0.001).Conclusion. Eight weeks of VLCD was an effective intervention in obese subjects. These beneficial effects may be associated with enhanced hepatic and whole-body lipolysis and oxidation.


Author(s):  
Amit Sohani ◽  
Chincholikar Sanjeev

Background: The basic cause of obesity is over nutrition easy and increasing availability of energy-dense, high-calorie foods/snacks and drinks are one of the factors that could significantly affect children’s energy intake.Methods: All adolescent school going boys and girls in the age group between 10 to 19 years were included as per definition of adolescent. 585 students were selected by systematic sample i.e. every third student was included in the study sample. A pretested standardized questionnaire which consisted of questions related to sociodemographic data and nutrition was used to screen the population for determining association between nutrition and obesity.Results: It can be observed that 28.21% students were vegetarian while remaining 71.79% were having mixed diet. It can be observed from the Table 2 that overweight and obesity are not related to frequency of consumption of meal, It can be seen that 30.97% overweight subjects had frequent junk food. There was a significant association between frequency of junk food and prevalence of overweight as well as obesity. 25.73% Students with overweight and obese subjects were frequent sweet eaters.Conclusions: Vegetarian diet or non-vegetarian diet did not have any effect on prevalence of underweight, overweight and obesity in adolescent population. Overweight and obesity are not related to frequency of consumption of meal. There was a significant association between frequency of junk foods, sweets with prevalence of overweight as well as obesity.


2001 ◽  
Vol 71 (1) ◽  
pp. 74-81 ◽  
Author(s):  
Rungsunn Tungtrongchitr ◽  
Praneet Pongpaew ◽  
Benjaluck Phonrat ◽  
Siriwan Tribunyatkul ◽  
Duangkamol Viroonudomphol ◽  
...  

The weight, height, body mass index (BMI), waist/hip ratio, serum leptin and lipid profiles of 48 overweight (BMI _ 25.00) Thai males and 166 overweight Thai females, compared with 26 males and 81 females in a control group (BMI = 18.5–24.9 kg/m2), were investigated. Subjects for the study were those persons who turned up regularly for physical check-ups at the out-patient department, general practice section of the Rajvithi Hospital, Bangkok. The study was conducted between March–October, 1998. Statistically significantly higher levels of serum leptin, cholesterol, LDL-C, LDL-C/HDL-C ratio and triglyceride were found in the overweight compared with the control subjects. The median serum leptin concentration in overweight subjects was 19.6 (2.0–60.0 ng/ml) compared with 9.0 (range 1.0–30.0 ng/ml) in the control subjects (p < 0.001). The median values of leptin serum concentrations in the overweight and obese males were significantly higher than those of the overweight and obese females. A total of 66.7% (32 out of 48) of the overweight and obese males had elevated leptin levels, while elevated leptin levels were found in 87.3% (145 out of 166) of the overweight and obese females. A total of 18.8% and 21.1% of the overweight and obese males and females respectively had cholesterol concentrations of _ 6.48 mmol/l. However, the prevalence of low HDL-C (HDL-C _ 0.91 mmol/l) was found to be 41.7% in the overweight and obese males and 4.2% in the overweight and obese females. Statistically significant associations were found between weight, height, BMI, waist, hip, waist/hip ratio, HDL-C, and serum leptin in both overweight male and female subjects. A negative correlation was found between serum leptin and LDL-C/HDL-C ratio in both the overweight and obese subjects.


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