Video Capsule Endoscopy and Ingestible Electronics: Emerging Trends in Sensors, Circuits, Materials, Telemetry, Optics, and Rapid Reading Software

Real-time monitoring of the gastrointestinal tract in a safe and comfortable manner is valuable for the diagnosis and therapy of many diseases. Within this realm, our review captures the trends in ingestible capsule systems with a focus on hardware and software technologies used for capsule endoscopy and remote patient monitoring. We introduce the structure and functions of the gastrointestinal tract, and the FDA guidelines for ingestible wireless telemetric medical devices. We survey the advanced features incorporated in ingestible capsule systems, such as microrobotics, closed-loop feedback, physiological sensing, nerve stimulation, sampling and delivery, panoramic imaging with adaptive frame rates, and rapid reading software. Examples of experimental and commercialized capsule systems are presented with descriptions of their sensors, devices, and circuits for gastrointestinal health monitoring. We also show the recent research in biocompatible materials and batteries, edible electronics, and alternative energy sources for ingestible capsule systems. The results from clinical studies are discussed for the assessment of key performance indicators related to the safety and effectiveness of ingestible capsule procedures. Lastly, the present challenges and outlook are summarized with respect to the risks to health, clinical testing and approval process, and technology adoption by patients and clinicians.

A Nonclassical Sagnac Interferometer Using Coherence de Broglie Waves

A Sagnac interferometer has been a powerful tool for gyroscope, spectroscopy, and navigation based on the Sagnac effects between counterpropagating twin fields in a closed loop, whose difference phase is caused by Einstein’s special relativity. Here, a nonclassical version of a Sagnac interferometer is presented using completely different physics of coherence de Broglie waves (CBW) in a cavity, where CBW is a nonclassical feature overcoming the standard quantum limit governed by classical physics.

Slope-Assisted Brillouin-Based Distributed Fiber-Optic Sensing Techniques

Brillouin-based fiber-optic sensing has been regarded as a powerful distributed measurement tool for monitoring the conditions of modern large civil and geotechnical structures, since it provides continuous environmental information (e.g., temperature and strain) along the whole fiber used for sensing applications. In the past few decades, great research efforts were devoted to improve its performance in terms of measurement range, spatial resolution, measurement speed, sensitivity, and cost-effectiveness, of which the slope-assisted measurement scheme, achieved by exploiting the linear slope of the Brillouin gain spectrum (BGS), have paved the way for dynamic distributed fiber-optic sensing. In this article, slope-assisted Brillouin-based distributed fiber-optic sensing techniques demonstrated in the past few years will be reviewed, including the slope-assisted Brillouin optical time-domain analysis/reflectometry (SA-BOTDA/SA-BOTDR), the slope-assisted Brillouin dynamic grating (BDG) sensor, and the slope-assisted Brillouin optical correlation domain analysis/reflectometry (SA-BOCDA/SA-BOCDR). Avenues for future research and development of slope-assisted Brillouin-based fiber-optic sensors are also prospected.