The adoption and intensification of maize (Zea mays) farming has long been a topic of interest in Mississippian archaeology. At various times throughout the development and definition of “Mississippian” as a cultural tradition, maize has been cast as a central feature of Mississippian adaptation, alongside a suite of other traits that include long-distance exchange, platform mound building, and the development of ranked social systems. In (re-)considering the topic of Mississippian beginnings, we continue to interrogate the nature of the relationship between maize farming and Mississippian origins. Our archaeological review of regional patterns of plant production (archaeobotanical results) and plant consumption (isotopic results) reveals that Mississippians throughout southeastern and midwestern North America produced and consumed maize, but varied significantly in their levels of production and consumption.