Smartphone is a high technology of communication tool with various modern social aplication. Nowadays, smartphone has become basic needs of human being especially during this pandemic of covid-19 that affected almost the country around the world. Smartphone has been a tool that must be provided in ourdaily life. Using smartphone during this pandemic covid-19help the students to have online learning from home that can be related to internet acces. Smartphone can give positive and negative impacts for the students. The positive are students can make online conference with teachers without interaction to other people and also they can get some informations or news from other countries. The negatives are the social interactions among students will be worse because they can not make friends, low of caring others and environment, and being able to be selfish child. The writer uses this research to know the impact of using smartphone during paandemic of covid-19 to the social interaction of students in regency of Sukarami Palembang. . This research is a quantitative research with data analysis calculations using SPSS 26 using simple linear regression with respondents of 100 students who live in the sub-district of Sukarami. Data collection was carried out by observation, filling out questionnaires and documentation. The results showed that there was an effect of the use of smartphones on students' social interactions simultaneously with an F value of 112.157> 3.09 (Ftable). Likewise for the partial test with the t test, namely the t value of 5.718> 1.98 (t table). As for the coefficient of determination, the contribution of smartphone use contributed 53.4% to students' social interactions