Protein–Protein Interaction Regulators - Drug Discovery
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Published By Royal Society Of Chemistry

9781788011877

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CHAPTER 5. Small Molecule Inhibitors of E3 Ubiquitin Ligases

Protein–Protein Interaction Regulators - Drug Discovery ◽

10.1039/9781788016544-00109 ◽

2020 ◽

pp. 109-123

Author(s):

Nobumoto Watanabe ◽

Hiroyuki Osada

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitors ◽

Ubiquitin Ligases ◽

E3 Ubiquitin Ligases

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CHAPTER 2. Protein–Protein Interaction Networks in Human Disease

Protein–Protein Interaction Regulators - Drug Discovery ◽

10.1039/9781788016544-00025 ◽

2020 ◽

pp. 25-48

Author(s):

Brandon S. Dunn ◽

Sharad Awasthi ◽

S. Stephen Yi ◽

Nidhi Sahni

Keyword(s):

Protein Interaction ◽

Human Disease ◽

Protein Interaction Networks ◽

Interaction Networks ◽

Protein Protein Interaction ◽

Protein Protein Interaction Networks

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CHAPTER 12. Small-molecule Inhibitors of Myc–Max Interaction and DNA Binding

Protein–Protein Interaction Regulators - Drug Discovery ◽

10.1039/9781788016544-00302 ◽

2020 ◽

pp. 302-338

Author(s):

Steven Fletcher ◽

Edward V. Prochownik

Keyword(s):

Dna Binding ◽

Small Molecule ◽

Small Molecule Inhibitors

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CHAPTER 11. Discovery of AMG 232, a Small Molecule MDM2 Inhibitor in Clinical Development and its Back-up Clinical Candidate, AM-7209

Protein–Protein Interaction Regulators - Drug Discovery ◽

10.1039/9781788016544-00280 ◽

2020 ◽

pp. 280-301

Author(s):

Yosup Rew ◽

John Eksterowicz

Keyword(s):

Small Molecule ◽

Clinical Development ◽

Mdm2 Inhibitor ◽

Clinical Candidate

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CHAPTER 8. Discovery and Development of Mcl-1 Inhibitors as Anti-cancer Therapeutics: Hit to Clinical Candidate Optimization

Protein–Protein Interaction Regulators - Drug Discovery ◽

10.1039/9781788016544-00171 ◽

2020 ◽

pp. 171-208

Author(s):

Karson J. Kump ◽

Zaneta Nikolovska-Coleska

Keyword(s):

Cancer Therapeutics ◽

Anti Cancer ◽

Clinical Candidate

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CHAPTER 10. Small-molecule Modulators of Protein–Protein Interactions: Focus on 14-3-3 PPIs

Protein–Protein Interaction Regulators - Drug Discovery ◽

10.1039/9781788016544-00249 ◽

2020 ◽

pp. 249-279

Author(s):

L. Iralde-Lorente ◽

M. Botta ◽

C. Ottmann

Keyword(s):

Small Molecule ◽

Protein Interactions ◽

Protein Protein Interactions ◽

Small Molecule Modulators

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CHAPTER 9. Pharmacological Regulation and Functional Significance of Chromatin Binding by BET Tandem Bromodomains

Protein–Protein Interaction Regulators - Drug Discovery ◽

10.1039/9781788016544-00209 ◽

2020 ◽

pp. 209-248

Author(s):

Michael D. Olp ◽

Huarui Cui ◽

William C. K. Pomerantz ◽

Brian C. Smith

Keyword(s):

Functional Significance ◽

Chromatin Binding ◽

Pharmacological Regulation

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CHAPTER 7. Helix-mimetics as Protein–Protein Interaction Inhibitors

Protein–Protein Interaction Regulators - Drug Discovery ◽

10.1039/9781788016544-00147 ◽

2020 ◽

pp. 147-170

Author(s):

Gitashri Naiya ◽

Madhumita Chakraborty ◽

Piya Ghosh ◽

Siddhartha Roy

Keyword(s):

Protein Interaction ◽

Protein Protein Interaction ◽

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CHAPTER 6. Hydrogen Bond Surrogate Stabilized Helices as Protein–Protein Interaction Inhibitors

Protein–Protein Interaction Regulators - Drug Discovery ◽

10.1039/9781788016544-00124 ◽

2020 ◽

pp. 124-146

Author(s):

Daniel Yoo ◽

Paramjit S. Arora

Keyword(s):

Hydrogen Bond ◽

Protein Interaction ◽

Protein Protein Interaction ◽

Hydrogen Bond Surrogate

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Preface

Protein–Protein Interaction Regulators - Drug Discovery ◽

10.1039/9781788016544-fp007 ◽

2020 ◽

pp. P007-P009

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