Introduction. Kaposi sarcoma is a rare soft tissue tumor that may form masses
in the skin, lymph nodes, mucosa and many other organs. It has a strong male
predilection and is usually seen in the older population. It is caused by
human herpes virus 8. Risk factors include compromised immune system,
typically seen in patients with human immunodeficiency virus infection or
organ transplant recipients. Case Report. We report a 66-year-old Caucasian
woman with no previous history of human immunodeficiency virus infection,
immunosuppressive therapy or organ transplantation. She was referred to a
plastic surgeon by a dermatologist due to a suspected dermatofibroma
presenting with one solitary, firm nodule on the dorsal aspect of the foot
that she reported to have occurred a year before. A surgery was scheduled in
6 months, as the tumor was assessed as benign. After excisional biopsy and
histological evaluation without immunohistochemical staining, that was not
available, a diagnosis of benign myofibroblastic tumor was made. Later on, a
new similar tumor on the hand appeared and the diagnosis was changed into a
malignant tumor. Further pathological examination, using immunohistochemical
staining, confirmed Kaposi sarcoma. The malignant cells showed positive
immunostaining for CD34, CD31, D2-40, WT1, bcl-2, and human herpes virus 8,
but they were CD99 negative. Conclusion. Nonspecific clinical presentation
and absence of risk factors may mislead the doctors, delay the biopsy and
thus delay adequate treatment. In the same time, histological similarities
with other disorders and tumors may be challenging for pathologists and lead
to wrong diagnosis.
Kaposi Sarcoma of the Adrenal Gland Resembling Epithelioid Angiosarcoma: A Case Report
