Pathophysiology of valvar heart disease. The dynamic nature of mitral valve regurgitation

1982 ◽  
Vol 142 (5) ◽  
pp. 998-1001 ◽  
Author(s):  
G. L. Pierpont
2020 ◽  
Vol 8 (B) ◽  
pp. 802-806
Author(s):  
Renny Suwarniaty ◽  
Mohammad Saifur Rohman ◽  
Tinny Endang Hernowati ◽  
Wisnu Barlianto

BACKGROUND: Rheumatic heart disease (RHD) is recognized as a heart disease that occurs as a result of sequelae in acute rheumatic fever (ARF), characterized by the occurrence of defects in the heart valves. The most common manifestation of childhood RHD is mitral regurgitation (MR). The role of inflammation and oxidative stress in RHD also involves several components consisting of carboxy-terminal pro-peptide of Type I procollagen (PICP) and carboxy-terminal pro-peptide of Type III procollagen (PIIICP). AIM: The aim of this study was to know whether PICP and PIIICP can be used to measure the severity level of mitral valve regurgitation. METHODS: This research is considered as descriptive-analytic research, and using cross-sectional analysis. Forty RHD patients underwent echocardiographic examinations to measure Wilkin and effective regurgitant orifice area scores. Patients were classified into ARF without valve abnormalities, mild, moderate, and severe MR. PICP and PIIICP were with ARF through venous blood and ELISA was examined. Data were analyzed by employing SPSS 22 with p = 0.05). Wilkins scores and PICP levels have a regression coefficient of 0.296 with a p-value of 0.032. RESULTS: There was a significant difference in PICP level among the studied sample groups with a p = 0.012, (p < 0.05), with insignificant difference in PIIICP level among sample groups with a p = 0.083, greater than α = 0.05 (p > 0.05). Wilkins scores and PICP level have a regression coefficient of 0.296 with a p = 0.032 (p < 0.05), while PIIICP level has a regression coefficient of 0.093 with a p = 0.568 (p > 0.05). CONCLUSION: There is no significant increase indicated on PIIICP level, but PICP level indicates a significant increase in RHD group with severe mitral valve abnormalities. PICP can be used to measure the severity level of mitral valve regurgitation.  


2011 ◽  
Vol 96 (2) ◽  
pp. 182-187 ◽  
Author(s):  
Susumu Ishikawa ◽  
Keisuke Ueda ◽  
Kazuo Neya ◽  
Akio Kawasaki ◽  
Akihito Kakinuma ◽  
...  

Abstract We evaluated the availability of original “sandwich plasty” for the treatment of functional mitral regurgitation (FMR) associated with ischemic heart disease (IHD) and aortic valve disease (AVD). Forty-three patients were reviewed, including 27 IHD patients and 16 AVD patients. Preoperatively severe FMR was detected in 14 patients, moderate FMR in 26, and mild FMR in 3. The papillary muscle heads of anterior leaflets and posterior leaflets were approximated using Teflon-pledgeted 3-0 Ticron sutures at anterolateral and posteromedial commissural portions. After surgery, residual moderate FMR was observed in 1 patient and mild FMR in 3 patients. Tenting height of the mitral valve significantly decreased. FMR free rates 2 years after surgery were 93% among IHD patients and 83% in AVD patients. “Sandwich plasty” was simple and effective for the treatment of functional FMR caused by tethering effects due to left ventricular dilatation.


2021 ◽  
Vol 45 (3) ◽  
pp. 197-206
Author(s):  
Giovanni Alfonso Chiariello ◽  
Saimir Kuci ◽  
Guglielmo Saitto ◽  
Massimo Massetti ◽  
Ottavio Alfieri ◽  
...  

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