scholarly journals Role of N-terminal propeptide of type I and type III procollagen (PINP and PIIINP) towards the severity degree of mitral valve regurgitation in children’s rheumatic heart disease (RHD)

2021 ◽  
Author(s):  
Citra Tarannita ◽  
Renny Suwarniaty ◽  
Shahdevi Shahdevi ◽  
Sanarto Santoso ◽  
Hidayat Suyuti
2020 ◽  
Vol 8 (B) ◽  
pp. 802-806
Author(s):  
Renny Suwarniaty ◽  
Mohammad Saifur Rohman ◽  
Tinny Endang Hernowati ◽  
Wisnu Barlianto

BACKGROUND: Rheumatic heart disease (RHD) is recognized as a heart disease that occurs as a result of sequelae in acute rheumatic fever (ARF), characterized by the occurrence of defects in the heart valves. The most common manifestation of childhood RHD is mitral regurgitation (MR). The role of inflammation and oxidative stress in RHD also involves several components consisting of carboxy-terminal pro-peptide of Type I procollagen (PICP) and carboxy-terminal pro-peptide of Type III procollagen (PIIICP). AIM: The aim of this study was to know whether PICP and PIIICP can be used to measure the severity level of mitral valve regurgitation. METHODS: This research is considered as descriptive-analytic research, and using cross-sectional analysis. Forty RHD patients underwent echocardiographic examinations to measure Wilkin and effective regurgitant orifice area scores. Patients were classified into ARF without valve abnormalities, mild, moderate, and severe MR. PICP and PIIICP were with ARF through venous blood and ELISA was examined. Data were analyzed by employing SPSS 22 with p = 0.05). Wilkins scores and PICP levels have a regression coefficient of 0.296 with a p-value of 0.032. RESULTS: There was a significant difference in PICP level among the studied sample groups with a p = 0.012, (p < 0.05), with insignificant difference in PIIICP level among sample groups with a p = 0.083, greater than α = 0.05 (p > 0.05). Wilkins scores and PICP level have a regression coefficient of 0.296 with a p = 0.032 (p < 0.05), while PIIICP level has a regression coefficient of 0.093 with a p = 0.568 (p > 0.05). CONCLUSION: There is no significant increase indicated on PIIICP level, but PICP level indicates a significant increase in RHD group with severe mitral valve abnormalities. PICP can be used to measure the severity level of mitral valve regurgitation.  


2018 ◽  
Vol 36 ◽  
pp. e255
Author(s):  
Tanima Banerjee ◽  
Somaditya Mukherjee ◽  
Sudip Ghosh ◽  
Monodeep Biswas ◽  
Santanu Datta ◽  
...  

2021 ◽  
Author(s):  
Luke David Hunter ◽  
Anton F. Doubell ◽  
Alfonso J. K. Pecoraro ◽  
Mark Monaghan ◽  
Guy Lloyd ◽  
...  

2021 ◽  
Vol 30 ◽  
pp. S21-S22
Author(s):  
K.F.L. Lee ◽  
O.J.O.J. Lee ◽  
T.L.D. Chan ◽  
K.L.C. Ho ◽  
W.K.T. Au

2011 ◽  
Vol 21 (4) ◽  
pp. 436-443 ◽  
Author(s):  
Rachel H. Webb ◽  
Nigel J. Wilson ◽  
Diana R. Lennon ◽  
Elizabeth M. Wilson ◽  
Ross W. Nicholson ◽  
...  

AbstractAimsEchocardiography detects a greater prevalence of rheumatic heart disease than heart auscultation. Echocardiographic screening for rheumatic heart disease combined with secondary prophylaxis may potentially prevent severe rheumatic heart disease in high-risk populations. We aimed to determine the prevalence of rheumatic heart disease in children from an urban New Zealand population at high risk for acute rheumatic fever.Methods and resultsTo optimise accurate diagnosis of rheumatic heart disease, we utilised a two-step model. Portable echocardiography was conducted on 1142 predominantly Māori and Pacific children aged 10–13 years. Children with an abnormal screening echocardiogram underwent clinical assessment by a paediatric cardiologist together with hospital-based echocardiography. Rheumatic heart disease was then classified asdefinite, probable, orpossible. Portable echocardiography identified changes suggestive of rheumatic heart disease in 95 (8.3%) of 1142 children, which reduced to 59 (5.2%) after cardiology assessment. The prevalence ofdefiniteandprobablerheumatic heart disease was 26.0 of 1000, with 95% confidence intervals ranging from 12.6 to 39.4. Portable echocardiography overdiagnosed rheumatic heart disease with physiological valve regurgitation diagnosed in 28 children. A total of 30 children (2.6%) had non-rheumatic cardiac abnormalities, 11 of whom had minor congenital mitral valve anomalies.ConclusionsWe found high rates of undetected rheumatic heart disease in this high-risk population. Rheumatic heart disease screening has resource implications with cardiology evaluation required for accurate diagnosis. Echocardiographic screening for rheumatic heart disease may overdiagnose rheumatic heart disease unless congenital mitral valve anomalies and physiological regurgitation are excluded.


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