Discordant Chronic Myelocytic Leukemia in Identical Twins

1978 ◽  
Vol 138 (8) ◽  
pp. 1303
Author(s):  
Kong-oo Goh
Keyword(s):  
Identical Twins ◽  
Chronic Myelocytic Leukemia ◽  
Myelocytic Leukemia

scholarly journals Chronic Myelocytic Leukemia in Identical Twins and a Sibling

Blood ◽  
1968 ◽  
Vol 31 (2) ◽  
pp. 216-225 ◽  
Author(s):  
GEORGE K. TOKUHATA ◽  
CHARLES L. NEELY ◽  
DOROTHY L. WILLIAMS
Keyword(s):  
Peripheral Blood ◽  
Blood Cells ◽  
Genetic Factor ◽  
Philadelphia Chromosome ◽  
Chromosome Abnormalities ◽  
Identical Twins ◽  
Peripheral Blood Cells ◽  
Chronic Myelocytic Leukemia ◽  
Myelocytic Leukemia

Abstract Identical twins and their older brother have been studied: all diagnosed within a span of three months as having chronic myelocytic leukemia; both twins were symptomatic and the brother asymptomatic. Chromosome analyses were made on peripheral blood cells. The asymptomatic brother had never been treated. The Ph1 chromosome was present in each of the three siblings. A number of other chromosome abnormalities were found. Results were interpreted in terms of a probable genetic factor in the Philadelphia chromosome and susceptibility to chronic myelocytic leukemia.

scholarly journals Co60 Vitamin B12 Binding Capacity of Human Leukocytes

Blood ◽  
1962 ◽  
Vol 19 (2) ◽  
pp. 229-235 ◽  
Author(s):  
LEO M. MEYER ◽  
EUGENE P. CRONKITE ◽  
INEZ F. MILLER ◽  
CLAIRE W MULZAC ◽  
IRVING JONES
Keyword(s):  
Vitamin B12 ◽  
Human Serum ◽  
Polycythemia Vera ◽  
Binding Capacity ◽  
Chronic Myelocytic Leukemia ◽  
Nonspecific Binding ◽  
Two Phase ◽  
Intact Cells ◽  
Myelocytic Leukemia ◽  
Neutrophilic Leukocytes

Abstract 1. Mature neutrophilic leukocytes show the highest Co60B12 binding capacity. 2. Less mature granulocytes, "blast" forms and eosinophils have little or no Co60B12 binding capacity. 3. Disintegrated mature leukocytes from chronic myelocytic leukemia and polycythemia vera show higher B12 binding capacity than intact cells. 4. Mature leukocytes from patients with chronic myelocytic leukemia and polycythemia vera show a two-phase B12 curve suggesting specific and nonspecific binding, similar to that observed in human serum. 5. Disintegration products from mature neutrophilic leukocytes probably contribute largely to increased B12 binding capacity of serum in chronic myelocytic leukemia and polycythemia vera.

Sign in / Sign up

Export Citation Format

Share Document