scholarly journals Emerging Pharmacologic Targets in Cerebral Cavernous Malformation and Potential Strategies to Alter the Natural History of a Difficult Disease

2019 ◽  
Vol 76 (4) ◽  
pp. 492 ◽  
Author(s):  
Muhammad O. Chohan ◽  
Serena Marchiò ◽  
Leslie A. Morrison ◽  
Richard L. Sidman ◽  
Webster K. Cavenee ◽  
...  
Keyword(s):  
Natural History ◽  
Cavernous Malformation ◽  
Cerebral Cavernous Malformation ◽  
History Of

Familial Cerebral Cavernous Malformation Mimicking Cerebral Amyloid Angiopathy

2021 ◽  
pp. 10.1212/CPJ.0000000000001055
Author(s):  
Mohamed Ridha ◽  
Yasmin Aziz ◽  
Joseph Broderick
Keyword(s):  
Cerebral Amyloid Angiopathy ◽  
Cavernous Malformation ◽  
Pathogenic Mutation ◽  
Cerebral Cavernous Malformation ◽  
Amyloid Angiopathy ◽  
History Of ◽  
Cerebral Amyloid ◽  
Cerebral Microhemorrhages ◽  
Familial Cerebral Cavernous Malformation ◽  
Work Up

A 67-year-old man was referred from ophthalmology for possible cerebral amyloid angiopathy (CAA) discovered during work-up of possible optic neuropathy. MRI (figure 1) demonstrated innumerable periventricular, brainstem, and cortical cerebral microhemorrhages (CMH). Scattered, non-specific white matter hyperintensities was seen on T2-weighted imaging without surrounding hypointense rim. He had no hypertension, and the distribution was uncharacteristic for CAA. Despite absent family history of stroke or seizure, testing for familial cerebral cavernous malformation (FCCM) identified a pathogenic mutation of KRIT1 (c.382G>T).

The Radiographic Natural History of Patients with a Single Intracranial Cavernous Malformation (S43.003)

Neurology ◽  
2012 ◽  
Vol 78 (Meeting Abstracts 1) ◽  
pp. S43.003-S43.003
Author(s):  
S. Moore ◽  
R. Brown ◽  
T. Christianson ◽  
K. Flemming
Keyword(s):  
Natural History ◽  
Cavernous Malformation ◽  
History Of

scholarly journals Intraoperative rupture of brainstem cavernous malformation

2006 ◽  
Vol 21 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Gregory P. Lekovic ◽  
L. Fernando Gonzalez ◽  
Vini G. Khurana ◽  
Robert F. Spetzler
Keyword(s):  
Risk Factors ◽  
Natural History ◽  
Cavernous Malformation ◽  
Cavernous Malformations ◽  
History Of ◽  
Specific Factors ◽  
The Difference ◽  
Intraoperative Rupture ◽  
Brainstem Cavernous Malformation ◽  
Insight Into

✓Although cavernous malformations (CMs) are an important cause of intracranial hemorrhage, the natural history of these lesions is controversial. Both retrospective and prospective studies undertaken to define risk factors for hemorrhage from CMs have consistently identified the location of a lesion as a factor that has a significant impact on the rate of rupture, and brainstem CMs consistently have a higher rate of symptomatic hemorrhage than those at other locations. The mechanism underlying this disparity in rupture rates, however, remains obscure. Most authors attribute the difference, at least partially, to the sensitivity of the brainstem to hemorrhage. Regardless, the specific factors that cause a given CM to rupture are unknown. The authors report their first encounter with an intraoperative rupture of a CM in the brainstem. This case underscores the risks encountered during the surgical approach to brainstem CMs and may provide insight into the pathophysiological mechanisms underlying the rupture of these lesions.

scholarly journals Natural history of cavernous malformation

Neurology ◽  
2016 ◽  
Vol 86 (21) ◽  
pp. 1984-1991 ◽  
Author(s):  
Shervin Taslimi ◽  
Amirhossein Modabbernia ◽  
Sepideh Amin-Hanjani ◽  
Fred G. Barker ◽  
R. Loch Macdonald
Keyword(s):  
Natural History ◽  
Cavernous Malformation ◽  
History Of

How is the moral stance related to the intentional stance and group thinking?

2020 ◽  
Vol 43 ◽  
Author(s):  
Hannes Rakoczy
Keyword(s):  
Natural History ◽  
Social Cognitive ◽  
Intentional Stance ◽  
Cognitive Capacities ◽  
Shared Intentionality ◽  
History Of ◽  
Group Thinking ◽  
Moral Stance

Abstract The natural history of our moral stance told here in this commentary reveals the close nexus of morality and basic social-cognitive capacities. Big mysteries about morality thus transform into smaller and more manageable ones. Here, I raise questions regarding the conceptual, ontogenetic, and evolutionary relations of the moral stance to the intentional and group stances and to shared intentionality.

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