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Ruminants ◽  
2022 ◽  
Vol 2 (1) ◽  
pp. 90-100
Author(s):  
Alicia T. Corlevic ◽  
David S. Beggs

This review provides insight on potential host-specific factors that increase individual susceptibility to infection and transmission of bovine digital dermatitis. Digital dermatitis is increasing in prevalence within herds worldwide and yields economic losses for producers and welfare issues for animals. A total of 34 relevant studies were reviewed based on the inclusion criteria. A decrease in susceptibility to disease was found in animals with specific genomic and hoof characteristics, thus citing the importance of sire selection when designing a breeding program. Animals with superior health status that lacked co-morbidities and mounted immune responses to infection were less likely to develop disease. Primiparous cattle and those in peak production were more likely to develop lesions, as were over-or-under-conditioned Holstein–Friesian breeds. Cattle with superior hoof conformation and gait were poor hosts for bacteria and therefore less likely to develop and spread infection. The lowest risk of transmission of digital dermatitis occurred during the dry period and post peak lactation and cattle with advanced lesions contributed to the persistence of the disease within a herd. It is hoped that this review will help producers design breeding and management programs for their herds, and help veterinarians advise clients on the subject.


2022 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Eldrede T. Kahiya ◽  
Caitlin Warwood

Purpose The purpose of this study is to organize and assess knowledge on the capabilities pertinent to the early internationalization of born globals (BGs) and international new ventures (INVs). Design/methodology/approach A systematic approach is used to search, code, organize and synthesize 155 peer-reviewed journal articles on capabilities and early internationalization. Findings The study delimits eight operational and five dynamic capabilities. The synthesis links capabilities to three antecedents (i.e. firm specific factors, managerial socio cognitive attributes and market factors) and three outcomes (i.e. precocity, survival and performance). While 7 of the 12 linkages identified are well-established, relationships involving market factors, survival and dynamic capabilities are sparsely researched. Research limitations/implications The authors know more about the effects of firm specific factors and managerial socio cognitive attributes on operational and dynamic capabilities than we do the influence of market factors on either group of capabilities. Likewise, the authors know more about the influence of operational and dynamic capabilities on performance than we do their impact on precocity or survival. Practical implications As the pandemic has shown, businesses with adaptable capabilities (e.g. shifting from a brick and mortar to an online/omnichannel approach or micro-breweries competent to switch from manufacturing beer to hand sanitizer) have increased their chance of survival while helping society cope. Originality/value This to the authors’ knowledge is the first study to provide a comprehensive review of literature on the nebulous concept of capabilities, in the context of the burgeoning research stream on early internationalization.


2022 ◽  
Vol 479 (1) ◽  
pp. 75-90
Author(s):  
Christina Ploumi ◽  
Margarita-Elena Papandreou ◽  
Nektarios Tavernarakis

Autophagy is a universal cellular homeostatic process, required for the clearance of dysfunctional macromolecules or organelles. This self-digestion mechanism modulates cell survival, either directly by targeting cell death players, or indirectly by maintaining cellular balance and bioenergetics. Nevertheless, under acute or accumulated stress, autophagy can also contribute to promote different modes of cell death, either through highly regulated signalling events, or in a more uncontrolled inflammatory manner. Conversely, apoptotic or necroptotic factors have also been implicated in the regulation of autophagy, while specific factors regulate both processes. Here, we survey both earlier and recent findings, highlighting the intricate interaction of autophagic and cell death pathways. We, Furthermore, discuss paradigms, where this cross-talk is disrupted, in the context of disease.


2022 ◽  
Vol 14 (2) ◽  
pp. 881
Author(s):  
Mimi Ravn ◽  
Gabriela Mach ◽  
Ellen Kathrine Hansen ◽  
Georgios Triantafyllidis

A holistic approach to daylight dynamics in our built environment can have beneficial outcomes for both physiological and visual effects on humans. Simulations of how daylight variables affect light levels on the horizontal work plane are compared to their physiological effects, measured as melanopic EDI (Melanopic Equivalent Daylight Illuminance) on a vertical plane. The melanopic EDI levels were calculated in a simulated office space in ALFA software (Adaptive Lighting for Alertness) employing the daylight variables of orientation, time of day, season, sky conditions and spatial orientation. Results were analyzed for how daylight design can contribute to the physiological effects of dynamic light in office buildings. Daylight is shown to be a sufficient light source in the majority of cases to meet the recommended values of EDI and provide the suggested horizontal lx level according to the Danish Standards. A mapping of daylight conditions, focusing on the specific factors presented here, can provide guidelines in the design process and future smart building systems. The complex interrelationship between these parameters is important to acknowledge when working with daylight dynamics as a sustainable element in architecture and lighting design.


2022 ◽  
pp. 875697282110458
Author(s):  
Ananth Natarajan

This article develops and describes rigorous oil and gas project forecasting methods. First, it builds a theoretical foundation by mapping megaproject performance literature to these projects. Second, it draws on heuristics and biases literature, using a questionnaire to demonstrate forecasting-related biases and principal-agent issues among industry project professionals. Third, it uses methodically collected project performance data to demonstrate that overrun distributions are non-normal and fat-tailed. Fourth, reference-class forecasting is demonstrated for cost and schedule uplifts. Finally, a predictive approach using machine learning (ML) considers project-specific factors to forecast the most likely cost and schedule overruns in a project.


2022 ◽  
Vol 14 (2) ◽  
pp. 748
Author(s):  
Ioana Manafi ◽  
Monica Roman

The final destination country for refugees heading to Europe may be a changing one depending on various factors, such as the relocation program at the EU level, their ability to make decisions, geographic factors, finances, available routes, visa options, networks, chance, labor markets, etc., but for many of them their choices are limited. The purpose of this paper is to show how refugees select their destination countries, by looking at similarities across European countries. We aim to explain how country-specific factors may relate to the magnitude of migration flows, employing cluster and network analysis, and connecting meso- and macro-levels. The variables considered in our analysis fall under the four types of factors for host countries described by Van Hear, Bakewell, and Long (2012). Our analysis reveals that host countries in Europe can be grouped into four clusters: (i) Top Destination Economically Performing Countries; (ii) Emergent Destination Countries; (iii) Periphery and Less Economically Performing Countries; and (iv) Outlier Countries.


2022 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Jan Lenning ◽  
Ida Gremyr ◽  
Hendry Raharjo

PurposeThis study aims to explore factors that contribute to auditee satisfaction in external audit fieldwork of ISO 9001, and relationships between these factors.Design/methodology/approachThe purpose is addressed through a single case study and based upon data collected by a questionnaire. Data were analysed using probabilistic graphical models.FindingsAn auditor's knowledge of operations is shown to be the single most important factor contributing to auditee satisfaction in the study. Furthermore, establishing a co-operative audit atmosphere and focussing on business improvements support the co-creation of value in the interaction between auditor and auditee, while a focus on ISO compliance appears to be more of a hygiene factor.Research limitations/implicationsThis paper is based on a study of one company and its interactions with one of the certification bodies for external auditing. Hence, the generalisability of the findings is limited by the case study method.Practical implicationsThis paper identifies that an auditor's knowledge of operations and a focus on improvements and co-creation of value can improve auditee satisfaction and appreciation of the audit process.Originality/valuePrevious research has concluded that audit fieldwork is a key attribute associated with auditee satisfaction. This paper adds to this body of knowledge by empirically examining the specific factors within audit fieldwork that contribute to auditee satisfaction and focuses on value-creation in the audit process. By understanding these factors and moving towards a service perspective on audits with value co-creation as focus, it is possible to enhance the value of external audits.


Author(s):  
Arjan C. Y. Loenen ◽  
Jérôme Noailly ◽  
Keita Ito ◽  
Paul C. Willems ◽  
Jacobus J. Arts ◽  
...  

Introduction: 3D printed trussed titanium interbody cages may deliver bone stimulating mechanobiological strains to cells attached at their surface. The exact size and distribution of these strains may depend on patient-specific factors, but the influence of these factors remains unknown. Therefore, this study aimed to determine patient-specific variations in local strain patterns on the surface of a trussed titanium interbody fusion cage.Materials and Methods: Four patients eligible for spinal fusion surgery with the same cage size were selected from a larger database. For these cases, patient-specific finite element models of the lumbar spine including the same trussed titanium cage were made. Functional dynamics of the non-operated lumbar spinal segments, as well as local cage strains and caudal endplate stresses at the operated segment, were evaluated under physiological extension/flexion movement of the lumbar spine.Results: All patient-specific models revealed physiologically realistic functional dynamics of the operated spine. In all patients, approximately 30% of the total cage surface experienced strain values relevant for preserving bone homeostasis and stimulating bone formation. Mean caudal endplate contact pressures varied up to 10 MPa. Both surface strains and endplate contact pressures varied more between loading conditions than between patients.Conclusions: This study demonstrates the applicability of patient-specific finite element models to quantify the impact of patient-specific factors such as bone density, degenerative state of the spine, and spinal curvature on interbody cage loading. In the future, the same framework might be further developed in order to establish a pipeline for interbody cage design optimizations.


Author(s):  
Tian Chen Zeng ◽  
Joey T. Cheng ◽  
Joseph Henrich

Dominance captures behavioural patterns found in social hierarchies that arise from agonistic interactions in which some individuals coercively exploit their control over costs and benefits to extract deference from others, often through aggression, threats and/or intimidation. Accumulating evidence points to its importance in humans and its separation from prestige—an alternate avenue to high status in which status arises from information (e.g. knowledge, skill, etc.) or other non-rival goods. In this review, we provide an overview of the theoretical underpinnings of dominance as a concept within evolutionary biology, discuss the challenges of applying it to humans and consider alternative theoretical accounts which assert that dominance is relevant to understanding status in humans. We then review empirical evidence for its continued importance in human groups, including the effects of dominance—independently of prestige—on measurable outcomes such as social influence and reproductive fitness, evidence for specialized dominance psychology, and evidence for gender-specific effects. Finally, because human-specific factors such as norms and coalitions may place bounds on purely coercive status-attainment strategies, we end by considering key situations and contexts that increase the likelihood for dominance status to coexist alongside prestige status within the same individual, including how: (i) institutional power and authority tend to elicit dominance; (ii) dominance-enhancing traits can at times generate benefits for others (prestige); and (iii) certain dominance cues and ethology may lead to mis-attributions of prestige. This article is part of the theme issue ‘The centennial of the pecking order: current state and future prospects for the study of dominance hierarchies’.


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