Adverse Outcomes With Early Venous Thromboembolism Prophylaxis in Neurosurgical Trauma Patients—Are We Crossing the Blood-Brain Barrier?

JAMA Surgery ◽  
2021 ◽  
pp. e215766
Author(s):  
Purvi P. Patel ◽  
Patrick M. McCarthy ◽  
Matthew J. Martin
Keyword(s):  
Venous Thromboembolism ◽  
Blood Brain Barrier ◽  
Adverse Outcomes ◽  
Brain Barrier ◽  
Trauma Patients ◽  
Thromboembolism Prophylaxis ◽  
Venous Thromboembolism Prophylaxis ◽  
Blood Brain

scholarly journals Dose adjusting enoxaparin is necessary to achieve adequate venous thromboembolism prophylaxis in trauma patients

2013 ◽  
Vol 74 (1) ◽  
pp. 128-135 ◽  
Author(s):  
Todd W. Costantini ◽  
Emily Min ◽  
Kevin Box ◽  
Vy Tran ◽  
Robert D. Winfield ◽  
...  
Keyword(s):  
Venous Thromboembolism ◽  
Trauma Patients ◽  
Thromboembolism Prophylaxis ◽  
Venous Thromboembolism Prophylaxis

898: Enoxaparin Dosing for Venous Thromboembolism Prophylaxis in Geriatric Trauma Patients

2020 ◽  
Vol 49 (1) ◽  
pp. 446-446
Author(s):  
Lauren Schwaner ◽  
Janelle Poyant ◽  
Benjamin Johnson ◽  
Nikolay Bugaev ◽  
Katharine Nault
Keyword(s):  
Venous Thromboembolism ◽  
Geriatric Trauma ◽  
Trauma Patients ◽  
Thromboembolism Prophylaxis ◽  
Venous Thromboembolism Prophylaxis

scholarly journals Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Lawrence Vernetti ◽  
Albert Gough ◽  
Nicholas Baetz ◽  
Sarah Blutt ◽  
James R. Broughman ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Blood Brain Barrier ◽  
Adverse Outcomes ◽  
Brain Barrier ◽  
Functional Coupling ◽  
Animal Testing ◽  
Blood Brain ◽  
Organ Specific ◽  
Liver And Kidney

Abstract Organ interactions resulting from drug, metabolite or xenobiotic transport between organs are key components of human metabolism that impact therapeutic action and toxic side effects. Preclinical animal testing often fails to predict adverse outcomes arising from sequential, multi-organ metabolism of drugs and xenobiotics. Human microphysiological systems (MPS) can model these interactions and are predicted to dramatically improve the efficiency of the drug development process. In this study, five human MPS models were evaluated for functional coupling, defined as the determination of organ interactions via an in vivo-like sequential, organ-to-organ transfer of media. MPS models representing the major absorption, metabolism and clearance organs (the jejunum, liver and kidney) were evaluated, along with skeletal muscle and neurovascular models. Three compounds were evaluated for organ-specific processing: terfenadine for pharmacokinetics (PK) and toxicity; trimethylamine (TMA) as a potentially toxic microbiome metabolite; and vitamin D3. We show that the organ-specific processing of these compounds was consistent with clinical data, and discovered that trimethylamine-N-oxide (TMAO) crosses the blood-brain barrier. These studies demonstrate the potential of human MPS for multi-organ toxicity and absorption, distribution, metabolism and excretion (ADME), provide guidance for physically coupling MPS, and offer an approach to coupling MPS with distinct media and perfusion requirements.

A retrospective analysis of the effectiveness of low molecular weight heparin for venous thromboembolism prophylaxis in trauma patients

2014 ◽  
Vol 207 (5) ◽  
pp. 648-652 ◽  
Author(s):  
Yaroslav Gritsiouk ◽  
Damian A. Hegsted ◽  
Piroska Schlesinger ◽  
Stuart K. Gardiner ◽  
Kelly D. Gubler
Keyword(s):  
Molecular Weight ◽  
Venous Thromboembolism ◽  
Retrospective Analysis ◽  
Low Molecular Weight Heparin ◽  
Low Molecular Weight ◽  
Trauma Patients ◽  
Thromboembolism Prophylaxis ◽  
Venous Thromboembolism Prophylaxis

1327: Compliance of Venous Thromboembolism Prophylaxis in Adult Trauma Patients

2020 ◽  
Vol 49 (1) ◽  
pp. 670-670
Author(s):  
Nicole Fenner ◽  
Shan Wang ◽  
Kui Liu ◽  
Shahidul Islam ◽  
Adel Hanna ◽  
...  
Keyword(s):  
Venous Thromboembolism ◽  
Trauma Patients ◽  
Thromboembolism Prophylaxis ◽  
Venous Thromboembolism Prophylaxis

Recommendations for venous thromboembolism prophylaxis in pediatric trauma patients

2016 ◽  
Vol 80 (5) ◽  
pp. 695-701 ◽  
Author(s):  
Sheila J. Hanson ◽  
E. Vincent S. Faustino ◽  
Arash Mahajerin ◽  
Sarah H. O’Brien ◽  
Christian J. Streck ◽  
...  
Keyword(s):  
Venous Thromboembolism ◽  
Pediatric Trauma ◽  
Trauma Patients ◽  
Thromboembolism Prophylaxis ◽  
Venous Thromboembolism Prophylaxis

Venous Thromboembolism Prophylaxis in Orthopaedic Trauma Patients

2015 ◽  
Vol 29 (10) ◽  
pp. e355-e362 ◽  
Author(s):  
H. Claude Sagi ◽  
Jaimo Ahn ◽  
David Ciesla ◽  
Cory Collinge ◽  
Cesar Molina ◽  
...  
Keyword(s):  
Venous Thromboembolism ◽  
Trauma Patients ◽  
Orthopaedic Trauma ◽  
Thromboembolism Prophylaxis ◽  
Venous Thromboembolism Prophylaxis

Is Early Venous Thromboembolism Prophylaxis Safe in Trauma Patients With Intracranial Hemorrhage

2011 ◽  
Vol 70 (2) ◽  
pp. 324-329 ◽  
Author(s):  
Daniel M. Koehler ◽  
Jason Shipman ◽  
Mario A. Davidson ◽  
Oscar Guillamondegui
Keyword(s):  
Venous Thromboembolism ◽  
Intracranial Hemorrhage ◽  
Trauma Patients ◽  
Thromboembolism Prophylaxis ◽  
Venous Thromboembolism Prophylaxis
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