Ethanol for preventing preterm birth in threatened preterm labor

BackgroundPreterm birth is one of the leading causes of perinatal morbidity and mortality. Gut microbiome dysbiosis is closely related to adverse pregnancy outcomes. However, the role of the gut microbiome in the pathogenesis of preterm birth remains poorly studied.MethodWe collected fecal samples from 41 women (cases presenting with threatened preterm labor =19, 11 of which delivered preterm; gestational age-matched no-labor controls, all of which delivered at term = 22) were recruited for the study. We performed 16S rRNA amplicon sequencing to compare the composition of the gut microbiome in threatened preterm labor cases and controls and among women who delivered preterm and at term. By annotating taxonomic biomarkers with the Human Oral Microbiome Database, we observed an increased abundance of potential oral-to-gut bacteria in preterm patients.ResultsPatients with preterm birth showed a distinct gut microbiome dysbiosis compared with those who delivered at term. Opportunistic pathogens, particularly Porphyromonas, Streptococcus, Fusobacterium, and Veillonella, were enriched, whereas Coprococcus and Gemmiger were markedly depleted in the preterm group. Most of the enriched bacteria were annotated oral bacteria using the Human Oral Microbiome Database. These potential oral-to-gut bacteria were correlated with clinical parameters that reflected maternal and fetal status.ConclusionsThis study suggests that patients who deliver preterm demonstrate altered gut microbiome that may contain higher common oral bacteria.

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Cervical elastography using E-cervix for prediction of preterm birth in singleton pregnancies with threatened preterm labor

The Journal of Maternal-Fetal & Neonatal Medicine ◽

10.1080/14767058.2020.1716721 ◽

2020 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

Giovanni Nazzaro ◽

Gabriele Saccone ◽

Marilena Miranda ◽

Felice Crocetto ◽

Fulvio Zullo ◽

...

Keyword(s):

Preterm Birth ◽

Preterm Labor ◽

Threatened Preterm Labor ◽

Singleton Pregnancies

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The prediction of spontaneous preterm birth in women with threatened preterm labor using transvaginal ultrasound of the cervix

Ultrasound in Obstetrics and Gynecology ◽

10.1046/j.1469-0705.2001.abs05-3.x ◽

2001 ◽

Vol 18 ◽

pp. CEO-02-CEO-02

Author(s):

C.-M. Cook ◽

D. A. Ellwood

Keyword(s):

Preterm Birth ◽

Preterm Labor ◽

Transvaginal Ultrasound ◽

Spontaneous Preterm Birth ◽

Threatened Preterm Labor

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The anti-phospholipid antibody-dependent and independent effects of periodontopathic bacteria on threatened preterm labor and preterm birth

Archives of Gynecology and Obstetrics ◽

10.1007/s00404-013-2741-z ◽

2013 ◽

Vol 288 (1) ◽

pp. 65-72 ◽

Cited By ~ 11

Author(s):

Changchang Ye ◽

Sayaka Katagiri ◽

Naoyuki Miyasaka ◽

Pariksha Bharti ◽

Hiroaki Kobayashi ◽

...

Keyword(s):

Preterm Birth ◽

Preterm Labor ◽

Periodontopathic Bacteria ◽

Threatened Preterm Labor ◽

Independent Effects

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Chemokines Profiling of Patients with Preterm Birth

Mediators of Inflammation ◽

10.1155/2014/185758 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 18

Author(s):

Piotr Laudanski ◽

Adam Lemancewicz ◽

Pawel Kuc ◽

Karol Charkiewicz ◽

Barbara Ramotowska ◽

...

Keyword(s):

Preterm Birth ◽

Premature Birth ◽

Preterm Labor ◽

Biochemical Markers ◽

Clinical Signs ◽

Subclinical Infection ◽

Effective Prevention ◽

Threatened Preterm Labor ◽

Term Births

Introduction.Nowadays it is thought that the main cause of premature birth is subclinical infection. However, none of the currently used methods provide effective prevention to preterm labor. The aim of the study was to determine the concentration of selected chemokines in sera of patients with premature birth without clinical signs of infection (n=62), threatened preterm labor (n=47), and term births (n=28).Method.To assess the concentration of chemokines in the blood serum, we used a multiplex method, which allows the simultaneous determination of 40 chemokines per sample. The sets consist of the following chemokines: 6Ckine/CCL21, Axl, BTC, CCL28, CTACK/CCL27, CXCL16, ENA-78/CXCL5, Eotaxin-3/CCL26, GCP-2/CXC, GRO (GROα/CXCL1, GROβ/CXCL2 and GROγ/CXCL3), HCC-1/CCL14, HCC-4/CCL16, IL-9, IL-17F, IL18-BPa, IL-28A, IL-29, IL-31, IP-10/CXCL10, I-TAC/CXCL11, LIF, LIGHT/TNFSF14, Lymphotactin/XCL1, MCP-2/CCL8, MCP-3/CCL7, MCP-4/CCL13, MDC/CCL22, MIF, MIP-3α/CCL20, MIP-3-β/CCL19, MPIF-1/CCL23, NAP-2/CXCL7, MSPα, OPN, PARC/CCL18, PF4, SDF-1/CXCL12, TARC/CCL17, TECK/CCL25, and TSLP.Results.We showed possible implication of 4 chemokines, that is, HCC-4, I-TAC, MIP-3α, and TARC in women with symptoms of preterm delivery.Conclusion.On the basis of our findings, it seems that the chemokines may play role in the pathogenesis of preterm labor. Defining their potential as biochemical markers of preterm birth requires further investigation on larger group of patients.

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