Abstract. This study developed a model of Total Electron Content (TEC) over the African region. The TEC data were derived from radio occultation measurements done by the Constellation Observing System for Meteorology, Ionosphere, and Climate (COSMIC) satellites. Geomagnetically quiet time (Kp −20 nT) data during the years 2008–2011, and 2013–2017 were binned according to local time, seasons, solar flux level, geographic longitude, and dip latitude. Cubic B splines were fitted to the binned data to obtain the model. The model was validated using TEC data of the years 2012 and 2018. The validation exercise revealed that, approximation of observed TEC data by our model produces root mean squared error of 4.8 TECU. Moreover, the modeled TEC data correlated highly with the observed TEC data (r = 0.93). Our model is the first attempt to predict TECs over the entire African region by using extensive COSMIC TEC measurements. Due to the extensive input data and the good modeling technique, we were able to reproduce the well-known features such as local time, seasonal, solar activity, and spatial variations of TEC over the African region.