Ischemic white matter disease (Binswanger's disease)

2016 ◽  
pp. 13-14
Author(s):  
Saltanat Kamenova ◽  
Aida Kondybayeva ◽  
Assiya Akanova
Keyword(s):  
White Matter ◽  
White Matter Disease ◽  
Binswanger’S Disease ◽  
Binswanger's Disease

scholarly journals Trichotillomania in a dementia case

2011 ◽  
Vol 5 (1) ◽  
pp. 58-60
Author(s):  
Leonardo Caixeta ◽  
Danielly Bandeira Lopes
Keyword(s):  
White Matter ◽  
Vascular Dementia ◽  
Hair Pulling ◽  
Dementia Case ◽  
Binswanger’S Disease ◽  
Binswanger's Disease ◽  
The Right

Abstract We report an 87-year-old male case of hair pulling associated with a white-matter vascular dementia (Binswanger's disease). Trichotillomania in our case did not resolve using mirtazapine or anticholinesterasic medication. Trichotillomania seems to be related to a form of perseveration associated with dementia. The findings in this case suggest the abnormality involving white matter in the pathogenesis of trichotillomania, may constitute a defect in connectivity in the right frontal-subcortical circuit.

scholarly journals Consensus statement for diagnosis of subcortical small vessel disease

2015 ◽  
Vol 36 (1) ◽  
pp. 6-25 ◽  
Author(s):  
Gary A Rosenberg ◽  
Anders Wallin ◽  
Joanna M Wardlaw ◽  
Hugh S Markus ◽  
Joan Montaner ◽  
...  
Keyword(s):  
White Matter ◽  
Consensus Statement ◽  
Small Vessel Disease ◽  
Hereditary Diseases ◽  
Small Vessel ◽  
Progressive Damage ◽  
Lacunar Infarcts ◽  
Vessel Disease ◽  
Binswanger’S Disease ◽  
Binswanger's Disease

Vascular cognitive impairment (VCI) is the diagnostic term used to describe a heterogeneous group of sporadic and hereditary diseases of the large and small blood vessels. Subcortical small vessel disease (SVD) leads to lacunar infarcts and progressive damage to the white matter. Patients with progressive damage to the white matter, referred to as Binswanger’s disease (BD), constitute a spectrum from pure vascular disease to a mixture with neurodegenerative changes. Binswanger’s disease patients are a relatively homogeneous subgroup with hypoxic hypoperfusion, lacunar infarcts, and inflammation that act synergistically to disrupt the blood–brain barrier (BBB) and break down myelin. Identification of this subgroup can be facilitated by multimodal disease markers obtained from clinical, cerebrospinal fluid, neuropsychological, and imaging studies. This consensus statement identifies a potential set of biomarkers based on underlying pathologic changes that could facilitate diagnosis and aid patient selection for future collaborative treatment trials.

Increasing in situ nick end labeling of oligodendrocytes in white matter of patients with Binswanger's disease

2001 ◽  
Vol 10 (2) ◽  
pp. 55-62 ◽  
Author(s):  
Makoto Masumura ◽  
Ryuji Hata ◽  
Hiroyasu Akatsu ◽  
Kenji Kosaka ◽  
Takayuki Yamamoto ◽  
...  
Keyword(s):  
White Matter ◽  
Binswanger’S Disease ◽  
Binswanger's Disease

Periventricular white matter alterations, dementia, and binswanger's disease

1993 ◽  
Vol 9 (2) ◽  
pp. 87-102 ◽  
Author(s):  
David J. Libon ◽  
Rodney A. Swenson ◽  
Barbara L. Malamut ◽  
Mary Scanlon ◽  
H. Branch Coslett ◽  
...  
Keyword(s):  
White Matter ◽  
Periventricular White Matter ◽  
Binswanger’S Disease ◽  
Binswanger's Disease

Treatment of Mood Disorder Associated with Binswanger's Disease

1989 ◽  
Vol 154 (2) ◽  
pp. 259-261 ◽  
Author(s):  
Eileen M. Joyce ◽  
Raymond Levy
Keyword(s):  
Quality Of Life ◽  
White Matter ◽  
Mood Disorder ◽  
Cerebrovascular Disorder ◽  
Deep White Matter ◽  
Affective Component ◽  
Binswanger’S Disease ◽  
Affective Disturbance ◽  
Binswanger's Disease

Binswanger's disease is a cerebrovascular disorder affecting deep white matter and is associated with dementia and affective disturbance. In the case reported, the mood disorder was successfully treated with a combination of lithium and amitriptyline, resulting in an improved quality of life despite continuing cognitive decline. This underlines the importance of treating the affective component of organic dementing conditions on its own merit.

scholarly journals Binswanger's disease and quantitative fractional anisotropy

2009 ◽  
Vol 67 (2a) ◽  
pp. 179-184 ◽  
Author(s):  
Eliasz Engelhardt ◽  
Denise Madeira Moreira ◽  
Gilberto Sousa Alves ◽  
Maria Elisa Oliveira Lanna ◽  
Carlos Eduardo de Oliveira Alves ◽  
...  
Keyword(s):  
Neural Networks ◽  
White Matter ◽  
Characteristic Feature ◽  
Fractional Anisotropy ◽  
White Matter Hyperintensities ◽  
Executive Dysfunction ◽  
Fiber Tracts ◽  
Comparison Results ◽  
Binswanger’S Disease ◽  
Binswanger's Disease

OBJECTIVE: To study the integrity of the white matter in Binswanger's disease (BD) patients with quantitative fractional anisotropy (DTI-FA). METHOD: Controls (12) and patients with BD (12) were included. Scans performed with MR (GE Signa Horizon/1.5T). Fazekas's score=6 with white matter hyperintensities extension >75% assessed on FLAIR scans. Standard parameters for DTI-FA were used. ROIs placed in symmetrical regions on two axial planes, data pooled in anterior (frontal) and posterior (temporo-parieto-occipital) regions. Analysis with Functool. Statistics for anterior and posterior regions comparison. RESULTS: DTI-FA showed reduction of anisotropy, reflecting axonal damage and demyelination of fibers, more prominent in anterior in relation to posterior region, in BD patients in comparison to controls. CONCLUSION: Loss of integrity of fiber tracts reflects interruption of neural networks that subserve cognitive, behavioral, and motor integration. The more severely affected frontal region is related to executive dysfunction, a characteristic feature of Binswanger's disease.

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