Periventricular white matter alterations, dementia, and binswanger's disease

1993 ◽  
Vol 9 (2) ◽  
pp. 87-102 ◽  
Author(s):  
David J. Libon ◽  
Rodney A. Swenson ◽  
Barbara L. Malamut ◽  
Mary Scanlon ◽  
H. Branch Coslett ◽  
...  
Keyword(s):  
White Matter ◽  
Periventricular White Matter ◽  
Binswanger’S Disease ◽  
Binswanger's Disease

Binswanger's Disease: Some Neuropsychological Considerations

1990 ◽  
Vol 3 (1) ◽  
pp. 31-40 ◽  
Author(s):  
David J. Libon ◽  
Mary Scanlon ◽  
Rodney Swenson ◽  
H. Branch Coslet
Keyword(s):  
White Matter ◽  
Neuropsychological Functioning ◽  
Periventricular White Matter ◽  
Delayed Recall ◽  
Neuropsychological Measures ◽  
Deep White Matter ◽  
Binswanger’S Disease ◽  
Binswanger's Disease ◽  
Dementing Illness ◽  
Almost All

The literature regarding Binswanger's disease is reviewed. Emphasis is placed on reviewing the neuropsychological literature related to Binswanger's disease. In addition, a retrospective analysis was carried out among four groups of subjects (N = 61) who were divided according to the presence or absence of dementia and deep white-matter alterations. A main effect for deep white-matter alterations was found for almost all measures of diastolic and systolic blood pressure. Among the two nondemented groups there was an effect of deep white matter alteration on neuropsychological functioning. Subjects with deep white matter changes performed worse on tests of immediate and delayed recall of a prose passage. Among the two demented groups there were no differences on any of the neuropsychological measures, although subjects with deep white matter alterations exhibited a higher incidence of focal neurologic signs and stroke. We conclude that Binswanger's disease is probably more prevalent than currently appreciated. Also, among clinically nondemented individuals periventricular white-matter alterations may be associated with subtle but definable neuropsychological deficits, and these individuals may be at risk for developing a dementing illness. (J Geriatr Psychiatry Neurol 1990;3:31-40).

Ischemic white matter disease (Binswanger's disease)

2016 ◽  
pp. 13-14
Author(s):  
Saltanat Kamenova ◽  
Aida Kondybayeva ◽  
Assiya Akanova
Keyword(s):  
White Matter ◽  
White Matter Disease ◽  
Binswanger’S Disease ◽  
Binswanger's Disease

scholarly journals Trichotillomania in a dementia case

2011 ◽  
Vol 5 (1) ◽  
pp. 58-60
Author(s):  
Leonardo Caixeta ◽  
Danielly Bandeira Lopes
Keyword(s):  
White Matter ◽  
Vascular Dementia ◽  
Hair Pulling ◽  
Dementia Case ◽  
Binswanger’S Disease ◽  
Binswanger's Disease ◽  
The Right

Abstract We report an 87-year-old male case of hair pulling associated with a white-matter vascular dementia (Binswanger's disease). Trichotillomania in our case did not resolve using mirtazapine or anticholinesterasic medication. Trichotillomania seems to be related to a form of perseveration associated with dementia. The findings in this case suggest the abnormality involving white matter in the pathogenesis of trichotillomania, may constitute a defect in connectivity in the right frontal-subcortical circuit.

scholarly journals Consensus statement for diagnosis of subcortical small vessel disease

2015 ◽  
Vol 36 (1) ◽  
pp. 6-25 ◽  
Author(s):  
Gary A Rosenberg ◽  
Anders Wallin ◽  
Joanna M Wardlaw ◽  
Hugh S Markus ◽  
Joan Montaner ◽  
...  
Keyword(s):  
White Matter ◽  
Consensus Statement ◽  
Small Vessel Disease ◽  
Hereditary Diseases ◽  
Small Vessel ◽  
Progressive Damage ◽  
Lacunar Infarcts ◽  
Vessel Disease ◽  
Binswanger’S Disease ◽  
Binswanger's Disease

Vascular cognitive impairment (VCI) is the diagnostic term used to describe a heterogeneous group of sporadic and hereditary diseases of the large and small blood vessels. Subcortical small vessel disease (SVD) leads to lacunar infarcts and progressive damage to the white matter. Patients with progressive damage to the white matter, referred to as Binswanger’s disease (BD), constitute a spectrum from pure vascular disease to a mixture with neurodegenerative changes. Binswanger’s disease patients are a relatively homogeneous subgroup with hypoxic hypoperfusion, lacunar infarcts, and inflammation that act synergistically to disrupt the blood–brain barrier (BBB) and break down myelin. Identification of this subgroup can be facilitated by multimodal disease markers obtained from clinical, cerebrospinal fluid, neuropsychological, and imaging studies. This consensus statement identifies a potential set of biomarkers based on underlying pathologic changes that could facilitate diagnosis and aid patient selection for future collaborative treatment trials.

Increasing in situ nick end labeling of oligodendrocytes in white matter of patients with Binswanger's disease

2001 ◽  
Vol 10 (2) ◽  
pp. 55-62 ◽  
Author(s):  
Makoto Masumura ◽  
Ryuji Hata ◽  
Hiroyasu Akatsu ◽  
Kenji Kosaka ◽  
Takayuki Yamamoto ◽  
...  
Keyword(s):  
White Matter ◽  
Binswanger’S Disease ◽  
Binswanger's Disease

Treatment of Mood Disorder Associated with Binswanger's Disease

1989 ◽  
Vol 154 (2) ◽  
pp. 259-261 ◽  
Author(s):  
Eileen M. Joyce ◽  
Raymond Levy
Keyword(s):  
Quality Of Life ◽  
White Matter ◽  
Mood Disorder ◽  
Cerebrovascular Disorder ◽  
Deep White Matter ◽  
Affective Component ◽  
Binswanger’S Disease ◽  
Affective Disturbance ◽  
Binswanger's Disease

Binswanger's disease is a cerebrovascular disorder affecting deep white matter and is associated with dementia and affective disturbance. In the case reported, the mood disorder was successfully treated with a combination of lithium and amitriptyline, resulting in an improved quality of life despite continuing cognitive decline. This underlines the importance of treating the affective component of organic dementing conditions on its own merit.

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