This case study presents a young adult man with lymphoblastic leukaemia B who required total body
irradiation (TBI) as a conditioning regimen for haematopoietic progenitor cell transplant (HPT) as the only
curative treatment option for his oncological disease. TBI was carried out with personalised patient
immobilisation, three-dimensional simulation, radiophysical planning and dosimetric calculations. A total
of 12 Gy were prescribed to be administered twice a day for 3 days in a row by means of volumetric
modulated intensity radiotherapy with several isocentres. The best technique for the administration of this
radiotherapy is discussed because, although the clinical efficacy of the administration of this body dose has
been well known for decades, technological advances have brought us new possibilities when compared to
the traditional TBI (bilateral with horizontal photon beam and absorbent screen). These advances include
the technique used in this case (multi-isocentre volumetric-radiotherapy), which allows a better doses
distribution, reducing the dose in organs at risk (OARs) and producing less toxicity, and therefore allowing
the inclusion of patients who would not tolerate a conventional TBI. In addition, this method would allow
the dose to be scaled up locally in higher areas at risk with better results in the disease control.
Effect of total body irradiation lung block parameters on lung doses using three‐dimensional dosimetry
