Clinical and Serologic Features in Patients With Incomplete Lupus Classification Versus Systemic Lupus Erythematosus Patients and Controls

Is systemic lupus erythematosus (SLE) is occurring more frequently now than in decades past? Despite improvements in the identification of patients with SLE, the development of new classification criteria, and the recognition of several biomarkers used alone or in combination, the diagnosis of SLE is still a challenge for clinicians, in particular early in the course of the disease, which makes the recognition of secular trends difficult to ascertain. Lacking a uniform definition of preclinical lupus or incomplete lupus, it is difficult to predict accurately which patients would go on to develop SLE. We will briefly review the classification criteria, early or preclinical SLE, the epidemiology of SLE, antinuclear antibodies-negative SLE, and biomarkers of the disease.

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Comprehensive Description of Clinical Characteristics of a Large Systemic Lupus Erythematosus Cohort from the Spanish Rheumatology Society Lupus Registry (RELESSER) With Emphasis on Complete Versus Incomplete Lupus Differences

Medicine ◽

10.1097/md.0000000000000267 ◽

2015 ◽

Vol 94 (1) ◽

pp. e267 ◽

Cited By ~ 28

Author(s):

Íñigo Rúa-Figueroa ◽

Patricia Richi ◽

Francisco Javier López-Longo ◽

María Galindo ◽

Jaime Calvo-Alén ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Clinical Characteristics ◽

Systemic Lupus ◽

Comprehensive Description ◽

Incomplete Lupus

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Protein array autoantibody profiles for insights into systemic lupus erythematosus and incomplete lupus syndromes

Clinical & Experimental Immunology ◽

10.1111/j.1365-2249.2006.03251.x ◽

2006 ◽

Vol 0 (0) ◽

pp. 061127015327005-??? ◽

Cited By ~ 10

Author(s):

Q.-Z. Li ◽

J. Zhou ◽

A. E. Wandstrat ◽

F. Carr-Johnson ◽

V. Branch ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Protein Array ◽

Systemic Lupus ◽

Autoantibody Profiles ◽

Incomplete Lupus

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Autoantibodies to C-Reactive Protein in Incomplete Lupus and Systemic Lupus Erythematosus

Journal of Investigative Medicine ◽

10.1097/jim.0000000000000094 ◽

2014 ◽

Vol 62 (6) ◽

pp. 890-893 ◽

Cited By ~ 5

Author(s):

Ju-Yang Jung ◽

Bo-Ram Koh ◽

Hyoun-Ah Kim ◽

Ja-Young Jeon ◽

Chang-Hee Suh

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

C Reactive Protein ◽

Systemic Lupus ◽

Reactive Protein ◽

Incomplete Lupus

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Organized Intraglomerular Deposits in NZB Mouse Disease

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100066772 ◽

1971 ◽

Vol 29 ◽

pp. 544-545

Author(s):

Francis R. Comerford ◽

Alan S. Cohen

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Antinuclear Antibodies ◽

Human Systemic Lupus Erythematosus ◽

Systemic Lupus ◽

Glomerular Lesion ◽

Ultrastructural Studies ◽

Dense Deposits ◽

Experimental Nephritis ◽

Glomerular Lesions

Mice of the inbred NZB strain develop a spontaneous disease characterized by autoimmune hemolytic anemia, positive lupus erythematosus cell tests and antinuclear antibodies and nephritis. This disease is analogous to human systemic lupus erythematosus. In ultrastructural studies of the glomerular lesion in NZB mice, intraglomerular dense deposits in mesangial, subepithelial and subendothelial locations were described. In common with the findings in many examples of human and experimental nephritis, including many cases of human lupus nephritis, these deposits were amorphous or slightly granular in appearance with no definable substructure.We have recently observed structured deposits in the glomeruli of NZB mice. They were uncommon and were found in older animals with severe glomerular lesions by morphologic criteria. They were seen most commonly as extracellular elements in subendothelial and mesangial regions. The deposits ranged up to 3 microns in greatest dimension and were often adjacent to deposits of lipid-like round particles of 30 to 250 millimicrons in diameter and with amorphous dense deposits.

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