scholarly journals Protein array autoantibody profiles for insights into systemic lupus erythematosus and incomplete lupus syndromes

2006 ◽  
Vol 0 (0) ◽  
pp. 061127015327005-??? ◽  
Author(s):  
Q.-Z. Li ◽  
J. Zhou ◽  
A. E. Wandstrat ◽  
F. Carr-Johnson ◽  
V. Branch ◽  
...  
Rheumatology ◽  
2017 ◽  
Vol 56 (8) ◽  
pp. 1407-1416 ◽  
Author(s):  
Pomme M. van der Meulen ◽  
Anouk M. Barendregt ◽  
Eloy Cuadrado ◽  
César Magro-Checa ◽  
Gerda M. Steup-Beekman ◽  
...  

Lupus ◽  
2019 ◽  
Vol 28 (9) ◽  
pp. 1031-1050 ◽  
Author(s):  
M F Ugarte-Gil ◽  
L A González ◽  
G S Alarcón

Is systemic lupus erythematosus (SLE) is occurring more frequently now than in decades past? Despite improvements in the identification of patients with SLE, the development of new classification criteria, and the recognition of several biomarkers used alone or in combination, the diagnosis of SLE is still a challenge for clinicians, in particular early in the course of the disease, which makes the recognition of secular trends difficult to ascertain. Lacking a uniform definition of preclinical lupus or incomplete lupus, it is difficult to predict accurately which patients would go on to develop SLE. We will briefly review the classification criteria, early or preclinical SLE, the epidemiology of SLE, antinuclear antibodies-negative SLE, and biomarkers of the disease.


2009 ◽  
Vol 36 (2) ◽  
pp. 416-421 ◽  
Author(s):  
ROMAN JURENCÁK ◽  
MARVIN FRITZLER ◽  
PASCAL TYRRELL ◽  
LINDA HIRAKI ◽  
SUSANNE BENSELER ◽  
...  

Objective.(1) To evaluate the spectrum of serum autoantibodies in pediatric-onset systemic lupus erythematosus (pSLE) with a focus on ethnic differences; (2) using cluster analysis, to identify patients with similar autoantibody patterns and to determine their clinical associations.Methods.A single-center cohort study of all patients with newly diagnosed pSLE seen over an 8-year period was performed. Ethnicity, clinical, and serological data were prospectively collected from 156/169 patients (92%). The frequencies of 10 selected autoantibodies among ethnic groups were compared. Cluster analysis identified groups of patients with similar autoantibody profiles. Associations of these groups with clinical and laboratory features of pSLE were examined.Results.Among our 5 ethnic groups, there were differences only in the prevalence of anti-U1RNP and anti-Sm antibodies, which occurred more frequently in non-Caucasian patients (p < 0.0001, p < 0.01, respectively). Cluster analysis revealed 3 autoantibody clusters. Cluster 1 consisted of anti-dsDNA antibodies. Cluster 2 consisted of anti-dsDNA, antichromatin, antiribosomal P, anti-U1RNP, anti-Sm, anti-Ro and anti-La autoantibody. Cluster 3 consisted of anti-dsDNA, anti-RNP, and anti-Sm autoantibody. The highest proportion of Caucasians was in cluster 1 (p < 0.05), which was characterized by a mild disease with infrequent major organ involvement compared to cluster 2, which had the highest frequency of nephritis, renal failure, serositis, and hemolytic anemia, or cluster 3, which was characterized by frequent neuropsychiatric disease and nephritis.Conclusion.We observed ethnic differences in autoantibody profiles in pSLE. Autoantibodies tended to cluster together and these clusters were associated with different clinical courses.


2013 ◽  
Vol 33 (5) ◽  
pp. 954-964 ◽  
Author(s):  
Sudhir Kumar Chauhan ◽  
Vikas Vikram Singh ◽  
Richa Rai ◽  
Madhukar Rai ◽  
Geeta Rai

2020 ◽  
Vol 2 (7) ◽  
pp. 415-423
Author(s):  
Carla J. Guthridge ◽  
Timothy Gross ◽  
Magdalene Quintero ◽  
Joseph M. Kheir ◽  
Jeremy Levin ◽  
...  

2014 ◽  
Vol 62 (6) ◽  
pp. 890-893 ◽  
Author(s):  
Ju-Yang Jung ◽  
Bo-Ram Koh ◽  
Hyoun-Ah Kim ◽  
Ja-Young Jeon ◽  
Chang-Hee Suh

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