NIR Light‐triggered Quantitative Pulsed Drug Release

2021 ◽  
pp. 2102362
Author(s):  
Yang Yang ◽  
Kaiqi Long ◽  
Yiqun Wang ◽  
Lei Li ◽  
Jiayue Shi ◽  
...  
Keyword(s):  
Drug Release ◽  
Nir Light

PEG–PEI-modified gated N-doped mesoporous carbon nanospheres for pH/NIR light-triggered drug release and cancer phototherapy

2021 ◽  
Author(s):  
Snigdharani Panda ◽  
Chandra Sekhar Bhol ◽  
Sujit Kumar Bhutia ◽  
Sasmita Mohapatra
Keyword(s):  
Drug Release ◽  
Mesoporous Carbon ◽  
Laser Excitation ◽  
Outer Shell ◽  
Carbon Nanospheres ◽  
Nir Light ◽  
Triggered Drug Release ◽  
Hybrid Nanoparticle

A hybrid nanoparticle consisting of N-doped mesoporous carbon nanospheres as core and thermosensitive PEG–PEI as outer shell shows multiple therapeutic actions such as PTT, PDT and NIR sensitive drug release under single 980 nm laser excitation.

scholarly journals Novel concept of the smart NIR-light–controlled drug release of black phosphorus nanostructure for cancer therapy

2018 ◽  
Vol 115 (3) ◽  
pp. 501-506 ◽  
Author(s):  
Meng Qiu ◽  
Dou Wang ◽  
Weiyuan Liang ◽  
Liping Liu ◽  
Yin Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Near Infrared ◽  
Black Phosphorus ◽  
Deep Penetration ◽  
Nir Light

A biodegradable drug delivery system (DDS) is one the most promising therapeutic strategies for cancer therapy. Here, we propose a unique concept of light activation of black phosphorus (BP) at hydrogel nanostructures for cancer therapy. A photosensitizer converts light into heat that softens and melts drug-loaded hydrogel-based nanostructures. Drug release rates can be accurately controlled by light intensity, exposure duration, BP concentration, and hydrogel composition. Owing to sufficiently deep penetration of near-infrared (NIR) light through tissues, our BP-based system shows high therapeutic efficacy for treatment of s.c. cancers. Importantly, our drug delivery system is completely harmless and degradable in vivo. Together, our work proposes a unique concept for precision cancer therapy by external light excitation to release cancer drugs. If these findings are successfully translated into the clinic, millions of patients with cancer will benefit from our work.

scholarly journals NIR-Responsive Lysosomotropic Phototrigger: ʽAIE + ESIPTʼ Active Naphthalene Based Single Component Photoresponsive Nanocarrier with Two-Photon Uncaging and Real-Time Monitoring Ability

2021 ◽  
Author(s):  
Biswajit Roy ◽  
Rakesh Mengji ◽  
Samrat Roy ◽  
Bipul Pal ◽  
Avijit Jana ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Real Time ◽  
Near Infrared ◽  
Single Component ◽  
Photon Absorption ◽  
Real Time Monitoring ◽  
Two Photon ◽  
Nir Light

In recent times, organelle-targeted drug delivery systems gained tremendous attention due to the site specific delivery of active drug molecules resulting in enhanced bioefficacy. In this context, the phototriggered drug delivery system (DDS) for releasing an active molecule is superior as it provides spatial and temporal control over the release. So far, near infrared (NIR) light responsive organelle targeted DDS has not yet been developed. Hence, we introduced a two-photon NIR-light responsive lysosome targeted ʽAIE + ESIPTʼ active single component DDS based on naphthalene chromophore. The Two-photon absorption cross-section of our DDS is 142 GM at 850 nm. The DDS was converted into pure organic nanoparticles for biological applications. Our nano-DDS is capable of selective targeting, AIE-luminogenic imaging, and drug release within the lysosome. In vitro studies using cancerous cell lines showed that our single component photoresponsive nanocarrier exhibited enhanced cytotoxicity and real-time monitoring ability of the drug release.

Near-infrared light-triggered drug release from UV-responsive diblock copolymer-coated upconversion nanoparticles with high monodispersity

2018 ◽  
Vol 6 (21) ◽  
pp. 3531-3540 ◽  
Author(s):  
Jun Xiang ◽  
Xia Tong ◽  
Feng Shi ◽  
Qiang Yan ◽  
Bing Yu ◽  
...  
Keyword(s):  
Drug Release ◽  
Diblock Copolymer ◽  
Near Infrared ◽  
Controlled Drug Release ◽  
Infrared Light ◽  
Upconversion Nanoparticles ◽  
Near Infrared Light ◽  
Nir Light ◽  
Triggered Drug Release

The preparation of a new near-infrared (NIR) light-responsive nanocarrier for controlled drug release is demonstrated.

Electrospun Upconverting Nanofibrous Hybrids with Smart NIR-Light-Controlled Drug Release for Wound Dressing

2020 ◽  
Vol 3 (10) ◽  
pp. 7219-7227
Author(s):  
Ho Ying Huang ◽  
Artiom Skripka ◽  
Liana Zaroubi ◽  
Brandon L. Findlay ◽  
Fiorenzo Vetrone ◽  
...  
Keyword(s):  
Drug Release ◽  
Wound Dressing ◽  
Controlled Drug Release ◽  
Nir Light

NIR Light-Activated Drug Release for Synergetic Chemo–Photothermal Therapy

2016 ◽  
Vol 14 (1) ◽  
pp. 242-251 ◽  
Author(s):  
Ahu Yuan ◽  
Wei Huan ◽  
Xiang Liu ◽  
Zhicheng Zhang ◽  
Yifan Zhang ◽  
...  
Keyword(s):  
Drug Release ◽  
Photothermal Therapy ◽  
Nir Light

NIR-responsive carbon-based nanocarriers for switchable on/off drug release and synergistic cancer therapy

2018 ◽  
Vol 6 (47) ◽  
pp. 7794-7799 ◽  
Author(s):  
Rongrong Nie ◽  
Hongji Liu ◽  
Lin Hu ◽  
Xinyu Gu ◽  
Junchao Qian ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Nir Light ◽  
Carbon Based

This communication reports a chitosan-gated carbon-based nanocarrier as a NIR light-switchable drug delivery system for controlled on/off drug release.

Coumarin-containing photo-responsive nanocomposites for NIR light-triggered controlled drug release via a two-photon process

2013 ◽  
Vol 1 (43) ◽  
pp. 5942 ◽  
Author(s):  
Weidong Ji ◽  
Najun Li ◽  
Dongyun Chen ◽  
Xiuxiu Qi ◽  
Wenwei Sha ◽  
...  
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
Two Photon ◽  
Nir Light ◽  
Photon Process

NIR light-responsive short peptide/2D NbSe2 nanosheets composite hydrogel with controlled-release capacity

2019 ◽  
Vol 7 (19) ◽  
pp. 3134-3142 ◽  
Author(s):  
Can Wu ◽  
Jing Liu ◽  
Bin Liu ◽  
Suyun He ◽  
Guoru Dai ◽  
...  
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Composite Hydrogel ◽  
Short Peptide ◽  
Nir Light ◽  
Release Capacity ◽  
Peptide Hydrogels

The design of light-responsive peptide hydrogels with controllable drug release characteristics is still a challenge.

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