scholarly journals Selective Degradation of Lignosulfonate and Lignin with Periodate to 5‐Iodovanillin

2022 ◽  
pp. 2100391
Author(s):  
Jana Klein ◽  
Kristian Alt ◽  
Siegfried R. Waldvogel
Keyword(s):  
Selective Degradation

Selective Degradation of Grindelic Acid and Its 3α-Hydroxy Analog: Facile Synthesis of Grindelistrictic Acids and Potential Intermediates for Erigerol

Synlett ◽  
1991 ◽  
Vol 1991 (09) ◽  
pp. 725-727 ◽  
Author(s):  
Takeshi Shimizu ◽  
Sayoko Hiranuma ◽  
Zhao-hui Qian ◽  
Hirosuke Yoshioka
Keyword(s):  
Facile Synthesis ◽  
Selective Degradation

scholarly journals Selective degradation of IKKα by autophagy is essential for arsenite-induced cancer cell apoptosis

2020 ◽  
Vol 11 (4) ◽  
Author(s):  
Qixing Tan ◽  
Shuxian Zou ◽  
Rui Jin ◽  
Yongliang Hu ◽  
Huan Xu ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Cell Apoptosis ◽  
Selective Degradation ◽  
Cancer Cell Apoptosis

scholarly journals Humanin is an endogenous activator of chaperone-mediated autophagy

2017 ◽  
Vol 217 (2) ◽  
pp. 635-647 ◽  
Author(s):  
Zhenwei Gong ◽  
Inmaculada Tasset ◽  
Antonio Diaz ◽  
Jaime Anguiano ◽  
Emir Tas ◽  
...  
Keyword(s):  
Quality Control ◽  
Cell Death ◽  
Heat Shock Protein 90 ◽  
Protective Effects ◽  
Neuroprotective Effects ◽  
Selective Degradation ◽  
Cytosolic Side ◽  
Chaperone Mediated Autophagy

Chaperone-mediated autophagy (CMA) serves as quality control during stress conditions through selective degradation of cytosolic proteins in lysosomes. Humanin (HN) is a mitochondria-associated peptide that offers cytoprotective, cardioprotective, and neuroprotective effects in vivo and in vitro. In this study, we demonstrate that HN directly activates CMA by increasing substrate binding and translocation into lysosomes. The potent HN analogue HNG protects from stressor-induced cell death in fibroblasts, cardiomyoblasts, neuronal cells, and primary cardiomyocytes. The protective effects are lost in CMA-deficient cells, suggesting that they are mediated through the activation of CMA. We identified that a fraction of endogenous HN is present at the cytosolic side of the lysosomal membrane, where it interacts with heat shock protein 90 (HSP90) and stabilizes binding of this chaperone to CMA substrates as they bind to the membrane. Inhibition of HSP90 blocks the effect of HNG on substrate translocation and abolishes the cytoprotective effects. Our study provides a novel mechanism by which HN exerts its cardioprotective and neuroprotective effects.

The synthesis and selective degradation of guaiol

1971 ◽  
Vol 12 (13) ◽  
pp. 855-858 ◽  
Author(s):  
James A. Marshall ◽  
Andrew E. Greene ◽  
Ronald Ruden
Keyword(s):  
Selective Degradation

Diketone-Mediated Photochemical Processes for Target-Selective Degradation of Dye Pollutants

2013 ◽  
Vol 1 (2) ◽  
pp. 167-171 ◽  
Author(s):  
Shujuan Zhang ◽  
Xitong Liu ◽  
Mengshu Wang ◽  
Bingdang Wu ◽  
Bingcai Pan ◽  
...  
Keyword(s):  
Photochemical Processes ◽  
Selective Degradation ◽  
Dye Pollutants

Conformational Dynamics and Binding Kinetics Drive Mutant Selective Degradation of EGFR

2021 ◽  
Author(s):  
Scott C. Rosenberg ◽  
Frances Shanahan ◽  
Sayumi Yamazoe ◽  
Marc Kschonsak ◽  
Yi J. Zeng ◽  
...  
Keyword(s):  
Conformational Dynamics ◽  
Binding Kinetics ◽  
Selective Degradation

Dominant effects of tubulin overexpression in Saccharomyces cerevisiae

1989 ◽  
Vol 9 (3) ◽  
pp. 1049-1059
Author(s):  
D Burke ◽  
P Gasdaska ◽  
L Hartwell
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Chromosome Loss ◽  
Beta Tubulin ◽  
Alpha Tubulin ◽  
Inducible Promoters ◽  
Selective Degradation ◽  
Novel Structure ◽  
Genes Encoding ◽  
Transient Overexpression ◽  
Mutant Phenotypes

The consequences of altering the levels of alpha- and beta-tubulin in Saccharomyces cerevisiae were examined by constructing fusions of the structural genes encoding the tubulins to strong galactose-inducible promoters. Overexpression of beta-tubulin (TUB2) was lethal: cells arrested in the G2 stage of the cell cycle exhibited an increased frequency of chromosome loss, were devoid of microtubules, and accumulated beta-tubulin in a novel structure. Overexpression of the major alpha-tubulin gene (TUB1) was not lethal and did not affect chromosome segregation. The rate of alpha-tubulin mRNA and protein synthesis was increased, but the protein did not accumulate. Overexpression of both alpha- and beta-tubulin together resulted in arrested cell division, and cells accumulated excess tubules that contained both alpha- and beta-tubulin. Transient overexpression of both tubulins resulted in a high frequency of chromosome loss. These data suggest that strong selective pressure exists to prevent excess accumulation of microtubules or beta-tubulin and suggest a model by which this goal may be achieved by selective degradation of unassembled alpha-tubulin. Furthermore, the phenotype of beta-tubulin overexpression is similar to the phenotype of a beta-tubulin deficiency. These results add to a number of recent studies demonstrating that mutant phenotypes generated by overexpression can be informative about the function of the gene product.

Precision Targeting of Mutant PI3Kα in Cancer by Selective Degradation

2022 ◽  
Vol 12 (1) ◽  
pp. 20-22
Author(s):  
Bart Vanhaesebroeck ◽  
John E. Burke ◽  
Ralitsa R. Madsen
Keyword(s):  
Selective Degradation
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