scholarly journals Superelasticity of Plasma‐ and Synthetic Membranes Resulting from Coupling of Membrane Asymmetry, Curvature, and Lipid Sorting

2021 ◽  
pp. 2102109
Author(s):  
Jan Steinkühler ◽  
Piermarco Fonda ◽  
Tripta Bhatia ◽  
Ziliang Zhao ◽  
Fernanda S. C. Leomil ◽  
...  
2020 ◽  
Author(s):  
Sourav Haldar ◽  
Kenta Okamoto ◽  
Peter M. Kasson

AbstractMany enveloped viruses infect cells within endocytic compartments. The drop in pH that accompanies endosomal maturation, often in conjunction with proteolytic factors, serves as a trigger for viral fusion proteins to insert into the endosomal membrane and drive fusion. The dynamics of this process has been studied by tracking viruses within living cells, which limits the precision with which fusion can be synchronized and controlled, and by reconstituting viral fusion to synthetic membranes, which introduces non-physiological membrane curvature and composition. To overcome these limitations, we have engineered the chemically controllable triggering of single-virus fusion within endosomes. We isolate influenza virus:endosome conjugates from cells prior to fusion, immobilize them in a microfluidic flow cell, and then rapidly and controllably trigger fusion. This platform demonstrates lipid-mixing kinetics that are grossly similar to influenza fusion with model membranes but display some subtle differences. Because it preserves endosomal membrane asymmetry and protein composition, it also provides a means to test how perturbations to endosomal trafficking and cellular restriction factors affect viral membrane fusion.


2021 ◽  
Vol 5 (6) ◽  
pp. 162
Author(s):  
Rasmeet Singh ◽  
Mandeep Singh ◽  
Nisha Kumari ◽  
Janak ◽  
Sthitapragyan Maharana ◽  
...  

Synthetic membranes are currently employed for multiple separation applications in various industries. They may have been prepared from organic or inorganic materials. Present research majorly focuses on polymeric (i.e., organic) membranes because they show better flexibility, pore formation mechanism, and thermal and chemical stability, and demand less area for installation. Dendritic, carbon nanotube, graphene and graphene oxide, metal and metal oxide, zwitter-ionic, and zeolite-based membranes are among the most promised water treatment membranes. This paper critically reviews the ongoing developments to utilize nanocomposite membranes to purify water. Various membranes have been reported to study their resistance and fouling properties. A special focus is given towards multiple ways in which these nanocomposite membranes can be employed. Therefore, this review provides a platform to develop the awareness of current research and motivate its readers to make further progress for utilizing nanocomposite membranes in water purification.


2016 ◽  
Vol 512 (1) ◽  
pp. 234-241 ◽  
Author(s):  
Alice Simon ◽  
Maria Inês Amaro ◽  
Anne Marie Healy ◽  
Lucio Mendes Cabral ◽  
Valeria Pereira de Sousa

2009 ◽  
Vol 10 (7) ◽  
pp. 442-443 ◽  
Author(s):  
Alicia Chung
Keyword(s):  

2021 ◽  
pp. 138631
Author(s):  
Kamilla M. Barcelos ◽  
Kaíque S.G.C. Oliveira ◽  
Domingos S.A. Silva ◽  
Ernesto A. Urquieta-González ◽  
Luís A.M. Ruotolo

2011 ◽  
Vol 2011 ◽  
pp. 1-3 ◽  
Author(s):  
Feyisayo Olafiranye ◽  
Win Kyaw ◽  
Oladipupo Olafiranye

Blood and dialyzer membrane interaction can cause significant thrombocytopenia through the activation of complement system. The extent of this interaction determines the biocompatibility of the membrane. Although the newer synthetic membranes have been shown to have better biocompatibility profile than the cellulose-based membranes, little is known about the difference in biocompatibility between synthetic membrane and modified cellulose membrane. Herein, we report a case of a patient on hemodialysis who developed dialyzer-membrane-related thrombocytopenia with use of synthetic membrane (F200NR polysulfone). The diagnosis of dialyzer membrane-associated thrombocytopenia was suspected by the trend of platelet count before and after dialysis, and the absence of other possible causes of thrombocytopenia. We observed significant improvement in platelet count when the membrane was changed to modified cellulose membrane (cellulose triacetate). In patients at high risk for thrombocytopenia, the modified cellulose membrane could be a better alternative to the standard synthetic membranes during hemodialysis.


Biomaterials ◽  
1997 ◽  
Vol 18 (19) ◽  
pp. 1299-1303 ◽  
Author(s):  
Nicholas A. Hoenich ◽  
Celia Woffindin ◽  
Susan Stamp ◽  
Sarah J. Roberts ◽  
Jean Turnbull

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