Endothelial nitric oxide synthase gene (NOS3) variant and hypertension in pregnancy

2001 ◽  
Vol 103 (3) ◽  
pp. 241-244 ◽  
Author(s):  
Gen Kobashi ◽  
Hideto Yamada ◽  
Kaori Ohta ◽  
Emi-Hirayama Kato ◽  
Yasuhiko Ebina ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Hypertension In Pregnancy ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
In Pregnancy

Does Endothelial Nitric Oxide Synthase Gene Variation Play a Role in the Occurrence of Hypertension in Pregnancy?

2003 ◽  
Vol 22 (2) ◽  
pp. 149-155 ◽  
Author(s):  
Elvira Grandone ◽  
Donatella Colaizzo ◽  
Pasquale Martinelli ◽  
Giuseppe Pavone ◽  
Massimo Errico ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Gene Variation ◽  
Hypertension In Pregnancy ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide ◽  
In Pregnancy

Localization of endothelial nitric oxide synthase in the normal and failing human atrial myocardium

1996 ◽  
Vol 54 ◽  
pp. 786-787
Author(s):  
Chi-Ming Wei ◽  
Margarita Bracamonte ◽  
Shi-Wen Jiang ◽  
Richard C. Daly ◽  
Christopher G.A. McGregor ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Heart Failure ◽  
Nitric Oxide Synthase ◽  
Endothelial Nitric Oxide Synthase ◽  
Cardiac Tissues ◽  
Mammalian Tissues ◽  
End Stage Heart Failure ◽  
End Stage ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Nitric oxide (NO) is a potent endothelium-derived relaxing factor which also may modulate cardiomyocyte inotropism and growth via increasing cGMP. While endothelial nitric oxide synthase (eNOS) isoforms have been detected in non-human mammalian tissues, expression and localization of eNOS in the normal and failing human myocardium are poorly defined. Therefore, the present study was designed to investigate eNOS in human cardiac tissues in the presence and absence of congestive heart failure (CHF).Normal and failing atrial tissue were obtained from six cardiac donors and six end-stage heart failure patients undergoing primary cardiac transplantation. ENOS protein expression and localization was investigated utilizing Western blot analysis and immunohistochemical staining with the polyclonal rabbit antibody to eNOS (Transduction Laboratories, Lexington, Kentucky).

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