Preliminary study of the safety and efficacy of donepezil hydrochloride in children with Down syndrome: A clinical report series

2007 ◽  
Vol 143A (13) ◽  
pp. 1408-1413 ◽  
Author(s):  
Gail A. Spiridigliozzi ◽  
James H. Heller ◽  
Blythe G. Crissman ◽  
Jennifer A. Sullivan-Saarela ◽  
Rebecca Eells ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Clinical Report ◽  
Safety And Efficacy ◽  
Children With Down Syndrome ◽  
Preliminary Study ◽  
Donepezil Hydrochloride

scholarly journals The Electrical Activity of the Orbicularis Oris Muscle in Children with Down Syndrome—A Preliminary Study

2021 ◽  
Vol 10 (23) ◽  
pp. 5611
Author(s):  
Liliana Szyszka-Sommerfeld ◽  
Magdalena Sycińska-Dziarnowska ◽  
Krzysztof Woźniak ◽  
Monika Machoy ◽  
Sławomir Wilczyński ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Electrical Activity ◽  
Healthy Children ◽  
Exclusion Criteria ◽  
Children With Down Syndrome ◽  
Electrical Potentials ◽  
Study Results ◽  
Orbicularis Oris Muscle ◽  
Preliminary Study ◽  
Muscular Effort

The aim of this study was to assess the electrical activity of the superior (SOO) and inferior (IOO) orbicularis oris muscles in children with Down syndrome (DS) and in children without DS. After applying the inclusion and exclusion criteria, 30 subjects were eligible to participate in the later stages of the research—15 subjects with DS (mean age 10.1 ± 1.1) and 15 healthy controls (mean age 9.8 ± 1.0). The electrical potentials of the SOO and IOO muscles were recorded using a DAB-Bluetooth electromyography machine (Zebris Medical GmbH, Germany) during the following tasks: At clinical rest, saliva swallowing, lip protrusion, lip compression, and production of the syllable/pa/. The Mann–Whitney U test was conducted to compare the study results between the groups. An analysis of the electromyographical (EMG) recordings showed that the electrical activity of the orbicularis oris muscle in children with DS and lip incompetence was significantly higher compared to healthy children during saliva swallowing, lip compression, and when producing the syllable/pa/, and this may suggest greater muscular effort due to the need to seal the lips during these functional conditions.

Safety and efficacy of rivastigmine in children with Down syndrome: A double blind placebo controlled trial

2016 ◽  
Vol 170 (6) ◽  
pp. 1545-1555 ◽  
Author(s):  
Gail A. Spiridigliozzi ◽  
Sarah J. Hart ◽  
James H. Heller ◽  
Heather E. Schneider ◽  
Jane Ann Baker ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Controlled Trial ◽  
Double Blind ◽  
Safety And Efficacy ◽  
Double Blind Placebo ◽  
Children With Down Syndrome

Hippotherapy and the Communicative Abilities of Children With Down Syndrome: A Preliminary Study

2019 ◽  
Vol 42 (2) ◽  
pp. 81-92
Author(s):  
Donna Jackson-Maldonado
Keyword(s):  
Down Syndrome ◽  
Sensory Integration ◽  
Language Production ◽  
Language Use ◽  
Motor Coordination ◽  
Language Therapy ◽  
Children With Down Syndrome ◽  
Traditional Language ◽  
Preliminary Study ◽  
Communicative Abilities

Hippotherapy uses the horse’s movement to enhance motor coordination, sensory integration, communication, and emotional stability in people with different disabilities. There is a need for evidence that proves increased efficiency in language use. In this study, we analyze the effect of hippotherapy on the communicative abilities of children with Down syndrome. Nine children between 4 and 7 years of age participated in two types of therapies: traditional language therapy and hippotherapy. Results showed effects of hippotherapy on language production and utterance length. Comprehension was enhanced by all therapy techniques. This preliminary study based on systematic evidence illustrates the effects of hippotherapy on communicative abilities.

The Effects of Co-Treatment on Concept Development in Children With Down Syndrome

2019 ◽  
Vol 41 (3) ◽  
pp. 176-187
Author(s):  
Emily Lund ◽  
Amanda Young ◽  
Rosalyna Yarbrough
Keyword(s):  
Down Syndrome ◽  
Preschool Children ◽  
Basic Concept ◽  
Individual Characteristics ◽  
Language Therapy ◽  
Children With Down Syndrome ◽  
Speech Language Pathologist ◽  
Learning Patterns ◽  
Physical Educator ◽  
Preliminary Study

This preliminary study investigated the effects of co-treatment by an adapted physical educator and speech-language pathologist on basic concept vocabulary learning in preschool children with Down syndrome as compared with the effects of treatment by either professional alone. In a Repeated Acquisition Design/Adapted Alternating Treatment study, 10 preschool children with Down syndrome were taught five basic concept words each week in a co-treatment intervention, in adapted physical education alone, or in speech-language therapy alone across 9 weeks. Each week, participants participated in a pre- and posttest. Four children learned the most words in the co-treatment condition and the remaining six children did not learn different numbers of words across conditions. Individual characteristics of children in the study were evaluated to determine possible factors that differentiate learning patterns among children. This preliminary study provides evidence that co-treatment may be effective for vocabulary teaching for some children with Down syndrome, particularly those with relatively high nonverbal intelligence.

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