Occurrence of DNET and other brain tumors in Noonan syndrome warrants caution with growth hormone therapy

2015 ◽  
Vol 170 (1) ◽  
pp. 195-201 ◽  
Author(s):  
Geoffrey D. McWilliams ◽  
Karen SantaCruz ◽  
Blaine Hart ◽  
Carol Clericuzio
Keyword(s):  
Growth Hormone ◽  
Brain Tumors ◽  
Hormone Therapy ◽  
Noonan Syndrome ◽  
Growth Hormone Therapy

Occurrence of Cranial Neoplasms in Pediatric Patients with Noonan Syndrome Receiving Growth Hormone: Is Screening with Brain MRI prior to Initiation of Growth Hormone Indicated?

2017 ◽  
Vol 88 (6) ◽  
pp. 423-426 ◽  
Author(s):  
Kanthi Bangalore Krishna ◽  
Pedro Pagan ◽  
Oscar Escobar ◽  
Jadranka Popovic
Keyword(s):  
Growth Hormone ◽  
Brain Tumors ◽  
Hormone Therapy ◽  
Noonan Syndrome ◽  
Growth Hormone Treatment ◽  
Growth Hormone Therapy ◽  
Brain Mri ◽  
Hormone Treatment ◽  
Tumor Burden ◽  
Primary Brain Tumors

Noonan syndrome (NS) is associated with short stature. Growth hormone treatment has been FDA approved for use in these patients. Children with NS are at a higher risk of developing benign and malignant proliferative disorders, primary brain tumors being one of them. Since growth hormone therapy can worsen the tumor burden, screening with a brain MRI prior to growth hormone initiation in NS patients is strongly recommended. Here we present two NS patients who developed different primary brain tumors while being on growth hormone therapy.

Does growth hormone therapy increase the frequency of tumor recurrence in children with brain tumors?

1987 ◽  
Vol 116 (3_Suppl) ◽  
pp. S188-S189 ◽  
Author(s):  
K.P. RODENS ◽  
S.L. KAPLAN ◽  
M.M. GRUMBACH ◽  
W.M. TELLER
Keyword(s):  
Growth Hormone ◽  
Brain Tumors ◽  
Hormone Therapy ◽  
Tumor Recurrence ◽  
Growth Hormone Therapy

scholarly journals Growth hormone therapy in pre-pubertal children with Noonan syndrome: first year growth response and comparison with Turner syndrome

1997 ◽  
Vol 86 (9) ◽  
pp. 943-946 ◽  
Author(s):  
J De Schepper ◽  
BJ Otten ◽  
I François ◽  
J-P Bourguignon ◽  
M Craen ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Hormone Therapy ◽  
Turner Syndrome ◽  
Noonan Syndrome ◽  
Growth Response ◽  
Growth Hormone Therapy ◽  
First Year

Gene Mutations in Noonan Syndrome: Implications for Responsiveness to Growth Hormone Therapy

2009 ◽  
Vol 24 (3) ◽  
pp. 238-239
Author(s):  
Giuseppe Piccoli ◽  
Isabel Couto ◽  
Deanna Maynard ◽  
John Germak
Keyword(s):  
Growth Hormone ◽  
Hormone Therapy ◽  
Noonan Syndrome ◽  
Growth Hormone Therapy ◽  
Gene Mutations
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