scholarly journals Improving rigor and reproducibility in nonhuman primate research

2021 ◽  
Author(s):  
Eliza Bliss‐Moreau ◽  
Rama R. Amara ◽  
Elizabeth A. Buffalo ◽  
Ricki J. Colman ◽  
Monica E. Embers ◽  
...  
Keyword(s):  
Nonhuman Primate ◽  
Primate Research

scholarly journals Translational impact of NIH-funded nonhuman primate research in transplantation

2019 ◽  
Vol 11 (500) ◽  
pp. eaau0143 ◽  
Author(s):  
Stuart J. Knechtle ◽  
Julia M. Shaw ◽  
Bernhard J. Hering ◽  
Kristy Kraemer ◽  
Joren C. Madsen
Keyword(s):  
Clinical Trials ◽  
Cell Therapy ◽  
Immune Responses ◽  
Nonhuman Primate ◽  
Immune Cell ◽  
National Institutes Of Health ◽  
Primate Research ◽  
Costimulation Blockade ◽  
Hematopoietic Chimerism ◽  
New Treatments

The National Institutes of Health (NIH) has long supported using nonhuman primate (NHP) models for research on kidney, pancreatic islet, heart, and lung transplantation. The primary purpose of this research has been to develop new treatments for down-modulating or preventing deleterious immune responses after transplantation in human patients. Here, we discuss NIH-funded NHP studies of immune cell depletion, costimulation blockade, regulatory cell therapy, desensitization, and mixed hematopoietic chimerism that either preceded clinical trials or prevented the human application of therapies that were toxic or ineffective.

Social Psychobiologic Dysfunction Associated with Anabolic Steroid Abuse: A Review

1990 ◽  
Vol 4 (3) ◽  
pp. 275-284 ◽  
Author(s):  
Edward Gregg ◽  
W. Jack Rejeski
Keyword(s):  
Nonhuman Primate ◽  
Social Withdrawal ◽  
Primate Research ◽  
Primate Model ◽  
Psychological States ◽  
Steroid Abuse ◽  
Overt Behavior ◽  
Descriptive Research ◽  
The Social ◽  
Androgenic Steroids

This article reviews both human and nonhuman primate research dealing with the social psychobiologic effects of anabolic/androgenic steroids (AS). Descriptive research and anecdotal reports within the realm of sport suggest that AS may have a variety of psychological and behavioral effects including psychotic episodes and increased aggression. Recent investigations with a nonhuman primate model confirm that the effects of AS on psychological states and overt behavior can be quite varied, ranging from those that can be characterized as active (e.g., mania and aggression) to more passive states (e.g., depression and social withdrawal). There are also profound physiological effects of a biobehavioral origin that constitute a risk for cardiovascular disease. The most striking aspect of AS is that the effects of this drug are due to an interaction between its pharmacologic properties and the social milieu.

scholarly journals Minimally invasive neural stimulation with a novel ultra-sensitive step function opsin: implications and future directions

2020 ◽  
Vol 124 (5) ◽  
pp. 1312-1314
Author(s):  
Aamna Lawrence ◽  
Hui Ho Vanessa Chang
Keyword(s):  
Minimally Invasive ◽  
Nonhuman Primate ◽  
Neural Circuits ◽  
Step Function ◽  
Neural Stimulation ◽  
Primate Research ◽  
Future Directions ◽  
Cortical Areas ◽  
Light Delivery ◽  
And Behavior

Optogenetics has become a popular tool to probe the link between neural circuits and behavior, since the technique was first introduced in 2005. Recently, Gong et al. (Gong X, Mendoza-Halliday D, Ting JT, Kaiser T, Sun X, Bastos AM, Wimmer RD, Guo B, Chen Q, Zhou Y, Pruner M, Wu CWH, Park D, Deisseroth K, Barak B, Boyden ES, Miller EK, Halassa MM, Fu Z, Bi G, Desimone R, Feng G. Neuron 107: 38–51, 2020) developed an ultra-sensitive step-function opsin capable of activating any region of the mouse brain and cortical areas in macaques with external illumination, thus aiming toward minimally invasive light delivery. In this article, we highlight and discuss the new opsin's potential in nonhuman primate research.

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