HPV in the malignant transformation of sinonasal inverted papillomas: A meta‐analysis

Objective. To perform a systematic review and meta-analysis on studies that assess malignant transformation rates (MTR) of oral epithelial dysplasia. Materials and Methods. This review was planned and conducted in accordance with the meta-analysis of observational studies in epidemiology (MOOSE) guidelines. PubMed, EMBASE, Google Scholar, and Cochrane databases were screened to identify observational studies. Quality assessments were completed by two reviewers independently using the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. Pooled-malignant transformation rate (MTR) in person years, subgroup, sensitivity, and publication bias analysis were calculated using STATA 13.0 and Comprehensive Meta-Analysis software. Results. Sixteen observational cohort studies were identified with a total of 3708 participants from Asia, North America, and Europe. Analysis showed a MTR of 10.5% (pooled-MTR: 10.5, 95% CI: 3.7 to 17.3; fixed effect model, I2=0.0%; Q-value = 2.389; p>0.05) among patients with histologically confirmed oral epithelia dysplasia undergoing long-term follow-up. Higher MTR in person year were seen among the sever dysplastic cases (pooled-MTR: 14.4%, 95% CI: 5.3% to 23.5%), studies published in Europe (pooled-MTR: 12.6%, 95% CI: 8.0% to 24.3%), and retrospective studies (pooled-MTR: 11.0%, 95% CI: 2.2% to 19.9%). Conclusion. These studies show that oral epithelial dysplasia has a significant high rate of transformation to cancer.

Download Full-text

Squamous Cell Carcinoma of the Scalp Masquerading as Trichilemmal Tumor of the Scalp

International Journal of Head and Neck Surgery ◽

10.5005/jp-journals-10001-1201 ◽

2014 ◽

Vol 5 (3) ◽

pp. 144-147

Author(s):

Sudhir Naik ◽

Rajshekar Halkud ◽

A Nanjundappa ◽

Siddharth Biswas ◽

M Samskruthi ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Malignant Transformation ◽

Squamous Cell ◽

Meta Analysis ◽

External Beam Radiotherapy ◽

Management Protocol ◽

Proliferating Trichilemmal Tumor ◽

Enhanced Computed Tomography ◽

Split Skin

ABSTRACT Background Adnexal components tumors of the skin are very rare and are seen as benign lesions of the scalp in aged women. Trichilemmal tumor is usually benign and rarely under-goes malignant transformation in a stepwise manner starting with an adenomatous stage of the trichilemmal cyst to an epitheliomatous stage of the proliferating trichilemmal tumor (PTT) evolving into the carcinomatous stage of the malignant proliferating trichilemmal tumor (MPTT). Case report A 53-year-old woman reported with huge swelling in the posterior region of the scalp. The swelling was mobile and soft to firm in consistency not fixed to the skull bone. The surface was smooth and getting under the swelling was not possible, needle biopsy reported as trichilemmal tumor. Contrast enhanced computed tomography (CECT) neck did not show any nodes in the neck, especially the posterior compartment. The tumor was widely excised with 1 cm margin and the periosteum was kept intact with split skin graft. An area of periosteal adher ence to the tumor seen was excised. The histopathology report on serial sectioning reported grade 1 moderately differentiated squamous cell carcinoma (SCC). Postoperative external beam radiotherapy of 66 Gy was given. The patient is being followed up and no recurrence is seen. Conclusion Malignant transformation in a proliferating trichilemmal tumor a rare entity and should be differentiated from SCC and the better prognostic trichilemmal carcinoma. A protocolbased adjuvant therapy is available for squamous cell carcinoma but not for trichilemmal carcinoma (TLC) and MPTT. A major meta-analysis may help to establish a clinical outcome-based classification and management protocol for these tumors. How to cite this article Nanjundappa A, Halkud R, Venugopal B, Chavan P, Sidappa KT, Biswas S, Samskruthi M, Naik SM. Squamous Cell Carcinoma of the Scalp Masquerading as Trichi-lemmal Tumor of the Scalp. Int J Head Neck Surg 2014;5(3):144-147.

Download Full-text

Oral lichen planus has a very low malignant transformation rate: A systematic review and meta‐analysis using strict diagnostic and inclusion criteria

Journal of Oral Pathology and Medicine ◽

10.1111/jop.12996 ◽

2020 ◽

Cited By ~ 8

Author(s):

Majdy Idrees ◽

Omar Kujan ◽

Kate Shearston ◽

Camile S. Farah

Keyword(s):

Systematic Review ◽

Malignant Transformation ◽

Lichen Planus ◽

Oral Lichen Planus ◽

Meta Analysis ◽

Transformation Rate ◽

Inclusion Criteria ◽

Oral Lichen

Download Full-text

Laser excision of oral leukoplakia: Does it affect recurrence and malignant transformation? A systematic review and meta-analysis

Oral Oncology ◽

10.1016/j.oraloncology.2020.104850 ◽

2020 ◽

Vol 109 ◽

pp. 104850

Author(s):

Mariana de Pauli Paglioni ◽

Cesar Augusto Migliorati ◽

Isabel Schausltz Pereira Faustino ◽

Bruno Augusto Linhares Almeida Mariz ◽

Ana Luiza Oliveira Corrêa Roza ◽

...

Keyword(s):

Systematic Review ◽

Malignant Transformation ◽

Meta Analysis ◽

Oral Leukoplakia ◽

Laser Excision

Download Full-text

Additively protective effects of vitamin D and calcium against colorectal adenoma incidence, malignant transformation and progression: A systematic review and meta-analysis

Clinical Nutrition ◽

10.1016/j.clnu.2019.11.012 ◽

2020 ◽

Vol 39 (8) ◽

pp. 2525-2538 ◽

Cited By ~ 4

Author(s):

Dongdong Huang ◽

Siqin Lei ◽

Yihua Wu ◽

Menghan Weng ◽

Yuwei Zhou ◽

...

Keyword(s):

Systematic Review ◽

Vitamin D ◽

Malignant Transformation ◽

Colorectal Adenoma ◽

Meta Analysis ◽

Protective Effects

Download Full-text

A meta‑analysis of transcriptome datasets characterizes malignant transformation from melanocytes and nevi to melanoma

Oncology Letters ◽

10.3892/ol.2018.8861 ◽

2018 ◽

Cited By ~ 1

Author(s):

Daniel Ortega‑Bernal ◽

Claudia Gonz�lez‑De La Rosa ◽

Elena Arechaga‑Ocampo ◽

Miguel Alvarez‑Avitia ◽

Nora Moreno ◽

...

Keyword(s):

Malignant Transformation ◽

Meta Analysis

Download Full-text

HPV-Associated Benign Squamous Cell Papillomas in the Upper Aero-Digestive Tract and Their Malignant Potential

Viruses ◽

10.3390/v13081624 ◽

2021 ◽

Vol 13 (8) ◽

pp. 1624

Author(s):

Stina Syrjänen ◽

Kari Syrjänen

Keyword(s):

Digestive Tract ◽

Malignant Transformation ◽

Squamous Cell ◽

Hpv Infection ◽

Malignant Potential ◽

Early Age ◽

Hpv Prevalence ◽

Hpv Genotypes ◽

Squamous Cell Papilloma ◽

Inverted Papillomas

Squamous cell papilloma (SCP) in the upper aero-digestive tract is a rare disease entity with bimodal age presentation both at childhood and in adults. It originates from stratified squamous and/or respiratory epithelium. Traditionally, SCPs have been linked to chemical or mechanical irritation but, since the 1980s, they have also been associated with human papillomavirus (HPV) infection. Approximately 30% of the head and neck SCPs are associated with HPV infection, with this association being highest for laryngeal papillomas (76–94%), followed by oral (27–48%), sinonasal (25–40%), and oropharyngeal papillomas (6–7%). There is, however, a wide variation in HPV prevalence, the highest being in esophageal SCPs (11–57%). HPV6 and HPV11 are the two main HPV genotypes present, but these are also high-risk HPVs as they are infrequently detected. Some 20% of the oral and oropharyngeal papillomas also contain cutaneous HPV genotypes. Despite their benign morphology, some SCPs tend to recur and even undergo malignant transformation. The highest malignant potential is associated with sinonasal inverted papillomas (7–11%). This review discusses the evidence regarding HPV etiology of benign SCPs in the upper aero-digestive tract and their HPV-related malignant transformation. In addition, studies on HPV exposure at an early age are discussed, as are the animal models shedding light on HPV transmission, viral latency, and its reactivation.

Download Full-text