Impact of clinical symptoms and diagnosis: The electronic Person‐Specific Outcome Measure (ePSOM) development programme

Objective: To evaluate the frequency of venous insufficiency following deep vein thrombosis (DVT). Design: Follow-up 4 years after a verified DVT. Setting: University hospital in Malmö. Patients: Eighty-seven subjects with venographically verified DVT. Main outcome measure: To compare venous function in legs, with and without previous DVT, by venous straingauge plethysmography and its correlation with clinical symptoms and signs. Results: Fifty-two per cent of patients described general discomfort from the thrombotic leg at follow-up. Active leg ulcers were found in three patients (3%); there were no signs of venous insufficiency in 33% at clinical examination. Thirty-seven patients (75%) with ≥ 1 cm difference in calf circumference between the thrombotic and contralateral leg had suffered a proximal DVT. The refilling time T90 was pathological in 67% and the muscle pump function (RV) in 55%. In the nonthrombotic leg the corresponding figures were 53% and 40%. Nevertheless a positive correlation was found between RV of the thrombotic leg and the contralateral leg ( r = 0.33) but an even stronger correlation was found for T90 ( r = 0.74). Conclusion: Venous insufficiency was found in 60% of legs 4 years after DVT but was also found in 14% of legs without previous thrombosis. This may be caused not only by effects of the thrombosis but also by the ageing process.

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The Spinal Muscular Atrophy Health Index: Italian validation of a disease-specific outcome measure

Neuromuscular Disorders ◽

10.1016/j.nmd.2021.02.006 ◽

2021 ◽

Author(s):

Valeria A. Sansone ◽

Alice Pirola ◽

Andrea Lizio ◽

Lucia Catherine Greco ◽

Giorgia Coratti ◽

...

Keyword(s):

Spinal Muscular Atrophy ◽

Outcome Measure ◽

Muscular Atrophy ◽

Health Index ◽

Italian Validation ◽

Specific Outcome ◽

Disease Specific Outcome Measure ◽

Disease Specific

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Sino-nasal assessment questionnaire: a specific outcome measure for rhinosinusitis, but what is the range in the asymptomatic population?

The Journal of Laryngology & Otology ◽

10.1017/s0022215106004531 ◽

2006 ◽

Vol 121 (7) ◽

pp. 650-652

Author(s):

F Younis ◽

S Duvvi ◽

T Walker ◽

B Nirmal Kumar

Keyword(s):

Outcome Measure ◽

Healthy Adult ◽

Normal Population ◽

Adult Population ◽

Sinus Surgery ◽

Asymptomatic Group ◽

Symptom Scores ◽

Specific Outcome ◽

The Difference ◽

Assessment Questionnaire

The sino-nasal assessment questionnaire is a system used for scoring the symptoms of chronic rhinosinusitis. However, the range of scores for this questionnaire in the healthy adult population is unknown. We aimed to establish this by recruiting 100 healthy volunteers and comparing their sino-nasal assessment questionnaire scores with those of 100 individuals who had undergone sinus surgery for rhinosinusitis. The difference in mean scores in the symptomatic group (44.62) and the asymptomatic group (8.46) was statistically significant. However, there was substantial overlap between the scores of the two groups. Factors such as age, gender and smoking did not have a statistically significant impact on the eventual score in the asymptomatic group. We believe that symptom scores can only be used effectively when the range in the asymptomatic population is known. This is so that disease severity can be gauged in the context of the normal population and post-operative improvements can be forecast.

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Algoritm for diagnostics of appendicitis in childhood and SIRS

Trakia Journal of Sciences ◽

10.15547/tjs.2018.03.008 ◽

2018 ◽

Vol 16 (3) ◽

pp. 218-223

Author(s):

Y. Dimcheva ◽

Kr. Kalinova ◽

K. Georgiev

Keyword(s):

Inflammatory Response ◽

Outcome Measure ◽

Clinical Symptoms ◽

Primary Outcome Measure ◽

Systemic Inflammatory Response ◽

Secondary Outcome ◽

Secondary Outcome Measure ◽

C Reactive Protein ◽

Protein Levels ◽

Reactive Protein

The specific purpose of this study was to describe and characterize the systemic inflammatory response to appendicitis in childhood. The clinical symptoms of SIRS are present in a large proportion of patients . A study of high-risk patients showed that over a given period of time, 44-68% of the patients met the criteria for this condition, while at the same time they had proven infection up to 50%.The incidence of SIRS is even higher in the post-operative period and in trauma regardless of the presence or absence of infection. On the other hand, between 10% and 43% of patients with proven sepsis do not meet the SIRS criteria.The inclusion of a number of biological markers (C-reactive protein, procalcitonin, cytokines) aims to help differentiate SIRS with infectious and noninfectious etiology. Sixty six patients were studied, divided into four groups from onset of symptoms to diagnosis. The primary outcome measure was to determine the systemic inflammatory response to appendicitis according to the established groups of time intervals. The secondary outcome measure was the analysis of C-reactive protein for the same purpose. The variables of the systemic inflammatory response, according to diagnostic intervals, showed non-significant differences in white blood cell count. The temperature rose constantly after 48 h, reaching its peak after 72 h (p = 0.001), and the respiratory rate rose after 72 h (p < 0.0001). After 73 h, most patients had three or four systemic inflammatory response criteria (p < 0.0001). C-reactive protein levels rose progressively, showing higher levels after 48 h (p = 0.005). The inflammatory response to appendicitis is progressive, being more marked along the timeline from onset of symptoms to diagnosis. Key words: appendicitis, diagnostic SIRS, children, algoritm.

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