scholarly journals The association of the ANU‐ADRI Alzheimer risk index score with cognition in the FINGER study

2021 ◽  
Vol 17 (S10) ◽  
Author(s):  
Anette Hall ◽  
Mariagnese Barbera ◽  
Ruth Stephen ◽  
Jenni Lehtisalo ◽  
Tiia Ngandu ◽  
...  
Keyword(s):  
Risk Index ◽  
Index Score ◽  
Risk Index Score

The Multinational Association for Supportive Care in Cancer Risk Index: A Multinational Scoring System for Identifying Low-Risk Febrile Neutropenic Cancer Patients

2000 ◽  
Vol 18 (16) ◽  
pp. 3038-3051 ◽  
Author(s):  
Jean Klastersky ◽  
Marianne Paesmans ◽  
Edward B. Rubenstein ◽  
Michael Boyer ◽  
Linda Elting ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Supportive Care ◽  
Cancer Patients ◽  
Scoring System ◽  
Burden Of Illness ◽  
Risk Index ◽  
Index Score ◽  
Low Risk ◽  
Validation Set ◽  
Risk Index Score

PURPOSE: Febrile neutropenia remains a potentially life-threatening complication of anticancer chemotherapy, but some patients are at low risk for serious medical complications. The purpose of this study was to develop an internationally validated scoring system to identify these patients. MATERIALS AND METHODS: Febrile neutropenic cancer patients were observed in a prospective multinational study. Independent factors assessable at fever onset, predicting low risk of complications, on a randomly selected derivation set, were assigned integer weights to develop a risk-index score, which was subsequently tested on a validation set. RESULTS: On the derivation set (756 patients), predictive factors were a burden of illness indicating absence of symptoms or mild symptoms (weight, 5; odds ratio [OR], 8.21; 95% confidence interval [CI], 4.15 to 16.38) or moderate symptoms (weight, 3; OR, 3.70; 95% CI, 2.18 to 6.29); absence of hypotension (weight, 5; OR, 7.62; 95% CI, 2.91 to 19.89); absence of chronic obstructive pulmonary disease (weight, 4; OR, 5.35; 95% CI, 1.86 to 15.46); presence of solid tumor or absence of previous fungal infection in patients with hematologic malignancies (weight, 4; OR, 5.07; 95% CI, 1.97 to 12.95); outpatient status (weight, 3; OR, 3.51; 95% CI, 2.02 to 6.04); absence of dehydration (weight, 3; OR, 3.81; 95% CI, 1.89 to 7.73); and age less than 60 years (weight, 2; OR, 2.45; 95% CI, 1.51 to 4.01). On the validation set, a Multinational Association for Supportive Care in Cancer risk-index score ≥ 21 identified low-risk patients with a positive predictive value of 91%, specificity of 68%, and sensitivity of 71%. CONCLUSION: The risk index accurately identifies patients at low risk for complications and may be used to select patients for testing therapeutic strategies that may be more convenient or cost-effective.

Rater

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e20678-e20678
Author(s):  
B. Rangarajan ◽  
K. Prabhash ◽  
R. Nair ◽  
H. Menon ◽  
P. Jain ◽  
...  
Keyword(s):  
High Risk ◽  
Risk Stratification ◽  
Predictive Value ◽  
Risk Index ◽  
Febrile Episode ◽  
Index Score ◽  
Low Risk ◽  
Mascc Score ◽  
Sensitivity Specificity ◽  
Risk Index Score

e20678 Background: Management of neutropenic fever is based on risk stratification of the episode which helps in optimizing treatment. MASCC is the most commonly used for risk stratification Patients with a score of > 21 were regarded as low risk; patients with a score of <21 were regarded as high risk. We tried to validate the MASCC index for our ethnic population. Methods: Patients were recruited throughout a 12 month period. Inclusion criteria were diagnosis of hematolymphoid malignancy, neutropenic febrile episode secondary to chemotherapy or during induction therapy of acute leukemia and more than 18 years of age All patients were risk stratified, hospitalized and treated with broad-spectrum, empiric, intravenous antibiotic therapy until recovery or outcome of the event. The incidence of medical complications in both groups and death related to the neutropenic infection was recorded. The data was entered on SPSS software and MASCC criteria was analyzed for sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV). Results: A total of 81 febrile neutropenic episodes were included; 34 classified as low risk and 47 as high risk according to MASCC risk index score. The sensitivity, specificity, PPV, NPV and accuracy of MASCC risk index score were 45.5%, 40%, 11%, 82%, 40.7%. We subsequently analyzed the subset of Acute Myeloid Leukemia (AML) patients as they were the majority comprising of 62/81 episodes. The subset of AML patients risk stratified according to MASCC risk index showed sensitivity, specificity, PPV, NPV and accuracy of 71%, 25.5%, 11%, 87.5%, 31% respectively. Conclusions: In our patient group, the value of MASCC score is limited with poor sensitivity, specificity and PPV. This trend is also seen in the subset analysis of AML patients. The value of the MASCC index with the score of 21 as the cut-off between low risk and high risk seems limited in our patients and requires confirmation with larger set of patients. No significant financial relationships to disclose.

Validation of a scoring system to improve life expectancy prediction in advanced cancer patients

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e20507-e20507
Author(s):  
S. Pourchet ◽  
V. Montheil ◽  
S. Ropert ◽  
J. Alexandre ◽  
F. Goldwasser ◽  
...  
Keyword(s):  
Life Expectancy ◽  
Cancer Patients ◽  
Advanced Cancer ◽  
Scoring System ◽  
Risk Index ◽  
Index Score ◽  
Advanced Cancer Patients ◽  
Improve Life Expectancy ◽  
Validation Set ◽  
Risk Index Score

e20507 Background: Oncologists accurately estimates survival in 20% of cases for advanced cancer patients (J Clin Oncol 2005 23:6240–48), leading to prescribe chemotherapy until last weeks of life. This study aimed to develop a validated scoring system to prevent futility. Methods: Between January 2004 and November 2008, 500 evaluable out of 546 consecutive pts with uncurable metastatic solid tumors were entered in a prospective study. On a randomly selected derivation set, independent factors assessable at inclusion predicting 2-weeks survival by a multiple logistic regression, were assigned integer weights to develop a risk-index score, which was subsequently tested on a validation set. Results: On the derivation set (334 pts), predictive factors were: urea > 12 mmol/L (weight = 5; odds ratio (OR) = 3.72; 95% confidence interval (CI) = [1.59; 8.71], p = .002), Karnofsky Performance Status ≤ 30% (weight = 4; OR = 3.28; 95% CI = [1.80; 6.01], p < .001), leucocytes > 15 G/L (weight = 3; OR = 2.49; 95% CI = [1.18; 5.25], p = .017), pre-albumin ≤ 0.05 (weight = 3; OR = 2.42; 95% CI = [1.16; 5.04], p = .019) and male gender (weight = 2; OR = 2.25; 95% CI = [1.28; 3.97], p = .005). On the validation set (166 pts), a risk-index score ≥ 7 identified high risk pts, with a sensitivity of 70 %, specificity of 62 % and a positive predictive value of 78 %. Conclusions: This score could help “go/no go” decisions of chemotherapy in advanced cancer patients and reduces errors of life expectancy prediction from 80% to 22%. No significant financial relationships to disclose.

A STUDY ON SURGICAL RESULTS OF ABDOMINAL AORTIC ANEURYSMS USING THE RISK INDEX SCORE

1991 ◽  
Vol 52 (3) ◽  
pp. 478-482
Author(s):  
Makoto SANO ◽  
Tadahiro KIMURA ◽  
Gento HAMAI ◽  
Tenzou SHIRAISHI ◽  
Masaaki SHINOHARA ◽  
...  
Keyword(s):  
Risk Index ◽  
Abdominal Aortic Aneurysms ◽  
Index Score ◽  
Aortic Aneurysms ◽  
Surgical Results ◽  
Abdominal Aortic ◽  
Risk Index Score
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