Cognitive performance predictors of incident motoric cognitive risk syndrome

Abstract Background Motoric cognitive risk syndrome (MCR) is defined by slow gait speed combined with subjective cognitive complaint. MCR is a predementia syndrome, similar to mild cognitive impairment (MCI). However, there is currently no study comparing the differences in cognitive performance and physical function between these two types of cognitive impairment. Thus, the aim of this study is to compare cognitive performance and physical function in individuals with MCR versus MCI. Methods A total of 77 participants, free of dementia, were recruited from the neurological outpatient clinic of a medical center in Taiwan. Participants were separated into two groups, MCR (n=33) and MCI (n=44) groups, based on definition criteria from previous studies. The priority was to assign a diagnosis of MCR first, followed by MCI. Hence, “pure” MCI had no overlap with MCR syndrome. Cognitive performance, including executive function, attention, working memory, episode memory, visuospatial function, and language, were measured. Physical functions such as activities in daily living, the Tinetti Assessment Scale, and the Timed Up and Go test were also measured. Results Executive function, attention, working memory, episodic memory and language were all significantly lower in the MCR group than the MCI group. Abilities related to physical function, including those measured by the Tinetti Assessment Scale and the Timed Up and Go test, were significantly lower in the MCR group than the MCI group. Conclusions We noted that cognitive performance and physical function were lower in MCR individuals than MCI but without MCR syndrome. However, the conclusions were based on the enrollment procedure of participants prioritizes the MCR syndrome. Because of the overlap of MCR and MCI, future studies should use different enrollment strategies to further clarify the status of these two populations.

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Motoric Cognitive Risk Syndrome: Prevalence and Cognitive Performance. A cross-sectional study

The Lancet Regional Health - Americas ◽

10.1016/j.lana.2021.100162 ◽

2022 ◽

Vol 8 ◽

pp. 100162

Author(s):

Isabel Marquez ◽

Elkin Garcia-Cifuentes ◽

Felipe Ramirez Velandia ◽

Angela Iragorri ◽

Ana Maria Saavedra ◽

...

Keyword(s):

Cognitive Performance ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Cognitive Risk

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Motoric cognitive risk syndrome: Prevalence and cognitive performance

Alzheimer s & Dementia ◽

10.1002/alz.049718 ◽

2021 ◽

Vol 17 (S8) ◽

Author(s):

Isabel C Márquez ◽

Elkin Garcia‐Cifuentes ◽

Felipe Ramirez Velandia ◽

Ana María Saavedra ◽

Miguel German Borda ◽

...

Keyword(s):

Cognitive Performance ◽

Cognitive Risk

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Do Cognitive Performance and Physical Function Differ between Individuals with Motoric Cognitive Risk Syndrome and those with Mild Cognitive Impairment?

10.21203/rs.3.rs-42676/v1 ◽

2020 ◽

Author(s):

Fang-Yu Cheng ◽

Yuanmay Chang ◽

Shih-Jung Cheng ◽

Jin-Siang Shaw ◽

Chuo-Yu Lee ◽

...

Keyword(s):

Working Memory ◽

Cognitive Impairment ◽

Executive Function ◽

Mild Cognitive Impairment ◽

Physical Function ◽

Cognitive Performance ◽

Assessment Scale ◽

Timed Up And Go ◽

Cognitive Risk ◽

Cognitive Complaint

Abstract Background Motoric cognitive risk syndrome (MCR) is defined by slow gait speed combined with subjective cognitive complaint. MCR is a predementia syndrome, similar to mild cognitive impairment (MCI). However, there is currently no study comparing the differences in cognitive performance and physical function between these two types of cognitive impairment. Thus, the aim of this study is to compare cognitive performance and physical function in individuals with MCR versus MCI. Methods A total of 77 participants, free of dementia, were recruited from the neurological outpatient clinic of a medical center in Taiwan. Participants were separated into two groups, MCR (n = 33) and MCI (n = 44) groups, based on definition criteria from previous studies. Cognitive performance, including executive function, attention, working memory, episode memory, visuospatial function, and language, were measured. Physical functions such as activities in daily living, the Tinetti Assessment Scale, and the Timed Up and Go test were also measured. Results Executive function, attention, working memory, episodic memory and language were all significantly lower in the MCR group than the MCI group. Abilities related to physical function, including those measured by the Tinetti Assessment Scale and the Timed Up and Go test, were significantly lower in the MCR group than the MCI group. Conclusions We noted that cognitive performance and physical function were lower in MCR individuals than MCI individuals. The significant differences between those two groups may provide insight that MCR might lead to more severe overall functional deterioration in older adults than MCI patients.

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Characterisation of Physiological Performance Measures in Arid and Humid Military Operational Environments

10.21203/rs.3.rs-673619/v1 ◽

2021 ◽

Author(s):

Edward Tom Ashworth ◽

Lauren Catherine Keaney ◽

James David Cotter ◽

Andrew Edward Kilding

Keyword(s):

Heart Rate ◽

Cognitive Performance ◽

Core Temperature ◽

Military Personnel ◽

Thermal Sensation ◽

Arid Environment ◽

Time To Exhaustion ◽

Humid Environment ◽

Performance Predictors ◽

Hot Environments

Abstract BackgroundMilitary personnel often deploy into hot environments that impose substantial strain on physical and cognitive performance. Hot environments can present as arid or humid and occur in different terrains, requiring different operational approaches. The aim of this study was to characterise the physiological, cognitive and perceptual strain experienced by military personnel during typical operations in arid and humid environments. MethodsNine pack-fit military personnel participated in two heat-stress tests to exhaustion, one in an arid environment (44°C, 21% humidity) and the other in a humid environment (33°C, 78% humidity). Participants walked at 5 km.h-1 while physiological, cognitive and perceptual measures were recorded. Tests were terminated volitionally, or by excessive core temperature or heart rate. Results The operational environments induced similar physiological stress, resulting in no difference in time to exhaustion (p = .155). The humid environment saw a greater elevation in core temperature (+0.3°C, p < .001) and heart rate (+5 b.min-1, p < .001). Skin temperature was greater in the arid environment (+0.4, p < .001) as was sweat evaporation (+0.3 L.h1, p = .045). Baseline performance predictors only provided moderate predictions of performance, whereas changes in perceptual measures provided the best performance predictors during the exercise, specifically perceptions relating to thermal sensation (β = -.65 - -.80) and sleepiness (β = -.79 - -.87). While no differences in cognitive performance were observed, greater cognitive stress was reported by participants over time, regardless of environment (all p < .011). ConclusionsThe humid operational environment elicited a greater thermal strain that may threaten safety, and impair performance, to a greater degree than the arid environment. Perceptual measures of thermal sensation and sleepiness were the best predictors of test termination and could likely be used to monitor thermal tolerance in field settings.

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Do Cognitive Performance and Physical Function Differ between Individuals with Motoric Cognitive Risk Syndrome and those with Mild Cognitive Impairment?

10.21203/rs.3.rs-42676/v3 ◽

2020 ◽

Author(s):

Fang-Yu Cheng ◽

Yuanmay Chang ◽

Shih-Jung Cheng ◽

Jin-Siang Shaw ◽

Chuo-Yu Lee ◽

...

Keyword(s):

Working Memory ◽

Cognitive Impairment ◽

Executive Function ◽

Mild Cognitive Impairment ◽

Physical Function ◽

Cognitive Performance ◽

Assessment Scale ◽

Timed Up And Go ◽

Cognitive Risk ◽

Cognitive Complaint

Abstract Background Motoric cognitive risk syndrome (MCR) is defined by slow gait speed combined with subjective cognitive complaint. MCR is a predementia syndrome, similar to mild cognitive impairment (MCI). However, there is currently no study comparing the differences in cognitive performance and physical function between these two types of cognitive impairment. Thus, the aim of this study is to compare cognitive performance and physical function in individuals with MCR versus MCI. Methods A total of 77 participants, free of dementia, were recruited from the neurological outpatient clinic of a medical center in Taiwan. Participants were separated into two groups, MCR (n=33) and MCI (n=44) groups, based on definition criteria from previous studies. The priority was to assign a diagnosis of MCR first, followed by MCI. Hence, “pure” MCI has no overlap with MCR syndrome. Cognitive performance, including executive function, attention, working memory, episode memory, visuospatial function, and language, were measured. Physical functions such as activities in daily living, the Tinetti Assessment Scale, and the Timed Up and Go test were also measured. Results Executive function, attention, working memory, episodic memory and language were all significantly lower in the MCR group than the MCI group. Abilities related to physical function, including those measured by the Tinetti Assessment Scale and the Timed Up and Go test, were significantly lower in the MCR group than the MCI group. Conclusions We noted that cognitive performance and physical function were lower in MCR individuals than MCI but without MCR syndrome. However, the conclusions were based on the enrollment procedure of participants prioritizes the MCR syndrome. Because of the overlap of MCR and MCI, future studies should use different enrollment strategies to further clarify the status of these two populations.

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Motoric Cognitive Risk Syndrome: Prevalence and Cognitive Performance

SSRN Electronic Journal ◽

10.2139/ssrn.3893561 ◽

2021 ◽

Author(s):

Isabel Márquez-Lugo ◽

Elkin Garcia-Cifuentes ◽

Angela Iragorri ◽

Felipe Ramirez Velandia ◽

Ana María Saavedra ◽

...

Keyword(s):

Cognitive Performance ◽

Cognitive Risk

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Motoric Cognitive Risk Syndrome: Prevalence and Cognitive Performance

Innovation in Aging ◽

10.1093/geroni/igab046.2272 ◽

2021 ◽

Vol 5 (Supplement_1) ◽

pp. 594-594

Author(s):

Isabela Marquez ◽

Carlos Cano ◽

Elkin Garcia-Cifuentes

Keyword(s):

Older Adults ◽

Cognitive Performance ◽

Older Adult ◽

Well Being ◽

Subjective Memory Complaints ◽

Subjective Memory ◽

Memory Complaints ◽

Cognitive Risk ◽

Confounding Variables ◽

Overall Mortality

Abstract Cognitive decline and dementia have a significant impact older adult. Motor Cognitive Risk Syndrome (MCRS) is a pre-dementia stage where slow gait speed and subjective memory complaints are present. MCRS increases the risk of frailty, dementia, disability, falls and overall mortality. We used data from the SABE Colombia study (Health, Well-Being, and Aging) conducted in 2015 in adults aged 60 years and older. After adjusting for confounding variables MCRS was associated with MMSE (OR 0.90, CI 0.82-0.99), pre-frail (OR 9.1, CI 3.26-25.47) and frail (OR 21.38, CI 6.30-72.57). This study found a prevalence of 5.45% of MCRS in Colombian older adults. We found an associations between cognitive performance (MMSE), frailty and MCRS. Our results increase the awareness of a pre-dementia stages different to Mild Cognitive Impairment (MCI), as these individuals are at greater risk than those with MCI to develop dementia.

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Do Cognitive Performance and Physical Function Differ between Individuals with Motoric Cognitive Risk Syndrome and those with Mild Cognitive Impairment?

10.21203/rs.3.rs-42676/v2 ◽

2020 ◽

Author(s):

Fang-Yu Cheng ◽

Yuanmay Chang ◽

Shih-Jung Cheng ◽

Jin-Siang Shaw ◽

Chuo-Yu Lee ◽

...

Keyword(s):

Working Memory ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Physical Function ◽

Cognitive Performance ◽

Medical Center ◽

Assessment Scale ◽

Timed Up And Go ◽

Cognitive Risk ◽

Cognitive Complaint

Abstract BackgroundMotoric cognitive risk syndrome (MCR) is defined by slow gait speed combined with subjective cognitive complaint. MCR is a predementia syndrome, similar to mild cognitive impairment (MCI). However, there is currently no study comparing the differences in cognitive performance and physical function between these two types of cognitive impairment. Thus, the aim of this study is to compare cognitive performance and physical function in individuals with MCR versus MCI. MethodsA total of 77 participants, free of dementia, were recruited from the neurological outpatient clinic of a medical center in Taiwan. Participants were separated into two groups, MCR (n=33) and MCI (n=44) groups, based on definition criteria from previous studies. Cognitive performance, including executive function, attention, working memory, episode memory, visuospatial function, and language, were measured. Physical functions such as activities in daily living, the Tinetti Assessment Scale, and the Timed Up and Go test were also measured. ResultsExecutive function, attention, working memory, episodic memory and language were all significantly lower in the MCR group than the MCI group. Abilities related to physical function, including those measured by the Tinetti Assessment Scale and the Timed Up and Go test, were significantly lower in the MCR group than the MCI group. ConclusionsWe noted that cognitive performance and physical function were lower in MCR individuals than MCI but without MCR individuals. The significant differences between those two groups may provide insight that MCR might lead to more severe overall functional deterioration in older adults than MCI but without MCR patients.

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The Relationship Between Spatio-temporal Gait Parameters and Cognitive Function: Protocol for a Cross-sectional Study

10.21203/rs.3.rs-1073451/v1 ◽

2021 ◽

Author(s):

Tatsuya Fukuoka ◽

Shun Irie ◽

Yoshiteru Watanabe ◽

Toshiki Kutsuna ◽

Akiko Abe

Keyword(s):

Cognitive Function ◽

Cognitive Performance ◽

Motion Capture ◽

Three Dimensional ◽

Measurement Unit ◽

Motion Capture System ◽

Large Sample ◽

Cognitive Risk ◽

Computer Based ◽

The Relationship

Abstract BackgroundMotor dysfunctions, such as slower walking speed, precede the occurrence of dementia and mild cognitive impairment, suggesting that walking parameters may be effective biomarkers for detecting early sub-clinical cognitive risk. In fact, while our preliminary study had a small sample, we found several walking parameters obtained by three-dimensional motion capture system, to be correlated with computer-based assessments of various cognitive function modalities. The Cognitive-Gait (CoGait) Database Project, described in the current protocol, aims to establish a database of multi-dimensional walking and cognitive performance data, collected from a large sample of healthy participants, crucial for detecting early sub-clinical cognitive risk. Methods: The study will recruit healthy volunteers, 20 years or older, without any neurological or musculoskeletal disorders. The estimated sample size is 450 participants, including a 10% attrition rate. Using computer-based cognitive assessments, all participants will perform six tasks: (i) the simple reaction time task, (ii) Go/No-Go task, (iii) Stroop Color–Word Test, (iv) N-back test, (v) Trail making test, and (vi) Digit Span test. Gait will be measured through joint kinematics and global positioning in participants’ lower legs, using pants with an inertial measurement unit-based three-dimensional motion capture system, while walking at a comfortable and faster pace. Finally, we will establish a prediction model for various cognitive performance modalities, based on walking performance. Discussion: This will be the first study to reveal the relationship between walking and cognitive performance using multi-dimensional data collected from a large sample of healthy adults, from the general population. Although there are several methodological limitations, such as accuracy of measurements, the CoGait database is expected to be the standard value for both walking and cognitive functions, supporting the evaluation of psychomotor function in early sub-clinical cognitive risk, including motoric-cognitive risk syndrome.Trial registration: None.

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