scholarly journals Amyloid aggregation in temporal regions is associated with longitudinal memory decline in cognitively unimpaired Apoe ‐ε4 carriers

2021 ◽  
Vol 17 (S5) ◽  
Author(s):  
Anna Brugulat‐Serrat ◽  
Gonzalo Sánchez‐Benavides ◽  
Raffaele Cacciaglia ◽  
Gemma Salvadó ◽  
Lyduine E. Collij ◽  
...  
Keyword(s):  
Amyloid Aggregation ◽  
Memory Decline ◽  
Apoe Ε4

scholarly journals Amyloid aggregation and subsequent memory decline over time in cognitively intact older identical twins

2020 ◽  
Vol 16 (S6) ◽  
Author(s):  
Jori Tomassen ◽  
Anouk den Braber ◽  
Maqsood Yaqub ◽  
Sandra D. Mulder ◽  
Charlotte E. Teunissen ◽  
...  
Keyword(s):  
Identical Twins ◽  
Amyloid Aggregation ◽  
Memory Decline ◽  
Cognitively Intact ◽  
Over Time

scholarly journals Apolipoprotein E (APOE) ε4 and episodic memory decline in Alzheimer’s disease: A review

2016 ◽  
Vol 27 ◽  
pp. 15-22 ◽  
Author(s):  
Mohamad El Haj ◽  
Pascal Antoine ◽  
Philippe Amouyel ◽  
Jean-Charles Lambert ◽  
Florence Pasquier ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Episodic Memory ◽  
Apolipoprotein E ◽  
Memory Decline ◽  
Apoe Ε4

scholarly journals Correcting Bias Caused by Missing Data in the Estimate of the Effect of Apolipoprotein ε4 on Cognitive Decline

2014 ◽  
Vol 21 (1) ◽  
pp. 85-90 ◽  
Author(s):  
Charles B. Hall ◽  
Richard B. Lipton ◽  
Mindy J. Katz ◽  
Cuiling Wang
Keyword(s):  
Missing Data ◽  
Community Sample ◽  
Joint Modeling ◽  
Cognitive Change ◽  
Memory Decline ◽  
Auxiliary Data ◽  
Loss To Follow Up ◽  
Apoe Ε4 ◽  
Age Related

AbstractLongitudinal administration of neuropsychological instruments are often used to assess age-related changes in cognition. Informative loss to follow-up may bias the results of these studies. Herein, we use auxiliary data to adjust for informative loss to follow-up. In the Einstein Aging Study, memory was assessed annually in a community sample of adults age 70+, free of dementia at baseline, using the free recall from the Free and Cued Selective Reminding Test, andviatelephone using the Memory Impairment Screen for Telephone (the auxiliary data). Joint linear mixed models were used to assess how the effect of the APOE ε4 genotype may be affected by informative missingness in the in-person data. A total of 620 EAS participants contributed 2085 person years of follow-up to the analyses. Memory decline rates estimated in joint models were 19% greater in ε4 negative participants and 27% greater in ε4 positive participants compared to traditional approaches; the effect of APOE ε4 on memory decline was 37% greater. Joint modeling methods can help address bias caused by informative missing data in the estimation of the effect of risk factors on cognitive change, and may be applicable to a broader range of outcomes in longitudinal aging studies. (JINS, 2014,20, 1–6)

scholarly journals Spouse-Appraised Memory Functioning Predicts Memory Decline Better Than Subjective Memory Complaints in Community Dwelling Older Adults at Genetic Risk for Alzheimer's Disease

2021 ◽  
Vol 12 ◽  
Author(s):  
Youssef Bellaali ◽  
John L. Woodard ◽  
Bernard Hanseeuw ◽  
Adrian Ivanoiu
Keyword(s):  
Older Adults ◽  
Community Dwelling ◽  
Carrier Status ◽  
Subjective Memory Complaints ◽  
Subjective Memory ◽  
Memory Decline ◽  
Apoe Ε4 ◽  
Memory Functioning ◽  
Community Dwelling Older Adults ◽  
With Memory

Objective: Alzheimer's disease (AD) begins with subtle memory decline, years before dementia onset. The presence of subjective memory complaints (SMC) has been proposed as a marker of preclinical AD. However, recent evidence has demonstrated early and progressive loss of awareness of memory difficulties in non-demented older adults harboring AD pathology. We investigated the respective contributions of SMC and spouse-appraised memory functioning (SAM) to predict memory decline in a large cohort of community dwelling older adults.Methods: The Wisconsin Longitudinal Study collected cognitive data from a community-based cohort of 3,583 participants in both 2005 and 2011. The participant and the participant's spouse were each asked to rate the participant's memory functioning using a Likert scale. We predicted change in objective episodic memory with models including baseline SMC, baseline SAM, or both SMC and SAM. We also evaluated an awareness index (SMC minus SAM). We then tested the interaction between Apolipoprotein E (APOE ε4) carrier status and SMC/SAM to evaluate whether the effects were driven by individuals at-risk for AD pathology.Results: In separate models, SMC (−0.081 ± 0.036, p = 0.025) and SAM (−0.084 ± 0.278, p = 0.003) were both associated with memory decline over ~6 years. However, the AI was not significantly associated with memory decline (0.031 ± 0.024, p = 0.19). When both predictors were included in the same model, SAM (−0.074 ± 0.03, p = 0.0092) was associated with memory decline, while SMC was not significant (−0.061 ± 0.04, p = 0.99). The association between SAM and memory decline was stronger in the APOE ε4 carriers than in the non-carriers (APOE-by-SAM interaction: F = 6.07; p = 0.002), and follow up analyses revealed that SAM was particularly predictive of decline only for APOE ε4 carriers. The association between SMC and memory decline was independent of APOE ε4 carrier status (APOE-by-SMC interaction: F = 2.29; p = 0.13).Conclusions: Spouse-appraised memory functioning was more predictive of memory decline than SMC or an awareness index, particularly in APOE ε4 carriers, who are at increased risk for AD pathology.

scholarly journals Amyloid-Related Memory Decline in Preclinical Alzheimer’s Disease Is Dependent on APOE ε4 and Is Detectable over 18-Months

PLoS ONE ◽  
2015 ◽  
Vol 10 (10) ◽  
pp. e0139082 ◽  
Author(s):  
Christine Thai ◽  
Yen Ying Lim ◽  
Victor L. Villemagne ◽  
Simon M. Laws ◽  
David Ames ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Preclinical Alzheimer’S Disease ◽  
Memory Decline ◽  
Apoe Ε4

APOE ε4 moderates amyloid-related memory decline in preclinical Alzheimer's disease

2015 ◽  
Vol 36 (3) ◽  
pp. 1239-1244 ◽  
Author(s):  
Yen Ying Lim ◽  
Victor L. Villemagne ◽  
Robert H. Pietrzak ◽  
David Ames ◽  
Kathryn A. Ellis ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Preclinical Alzheimer’S Disease ◽  
Memory Decline ◽  
Apoe Ε4

scholarly journals Longitudinal association between hippocampus atrophy and episodic‐memory decline in non‐demented APOE ε4 carriers

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Tetiana Gorbach ◽  
Sara Pudas ◽  
David Bartrés‐Faz ◽  
Andreas M. Brandmaier ◽  
Sandra Düzel ◽  
...  
Keyword(s):  
Episodic Memory ◽  
Memory Decline ◽  
Apoe Ε4 ◽  
Longitudinal Association ◽  
Hippocampus Atrophy

P4-198: Subjective memory symptoms, verbal memory decline and the APOE-ε4 allele

2013 ◽  
Vol 9 ◽  
pp. P778-P779
Author(s):  
Cécilia Samieri ◽  
Maria M. Glymour ◽  
Olivia I. Okereke ◽  
Francine Grodstein
Keyword(s):  
Verbal Memory ◽  
Subjective Memory ◽  
Memory Decline ◽  
Apoe Ε4 ◽  
Ε4 Allele

I Rate My Memory Quite Similar at Age 40 and at Age 70

GeroPsych ◽  
2020 ◽  
Vol 33 (4) ◽  
pp. 235-244
Author(s):  
Boo Johansson ◽  
Marcus Praetorius Björk ◽  
Valgeir Thorvaldsson
Keyword(s):  
Change Score ◽  
Subjective Memory ◽  
Memory Decline ◽  
Memory Factor ◽  
Invariance Testing ◽  
Adult Lifespan ◽  
Memory Functioning ◽  
Acceptable Model ◽  
Score Model ◽  
Old Men

Abstract. In 1987, we administered a subjective memory questionnaire to 143 40-year-old men, and 30 years later 67 of them again responded to the same questionnaire at age 70. At the follow-up, we also instructed participants to answer the questionnaire in the same manner as they thought they did at age 40 and to perform a picture recognition and a public event test. We employed confirmatory factor analysis to model a latent subjective memory construct. A single-factor solution provided acceptable model fit to data (χ2(12) = 9.33, p = .68; χ2(12) = 10.48, p = .57) and a decent reliability at both ages for the subjective memory measurements (omega = .82 and .93, respectively). Our longitudinal invariance testing revealed only a partial weak invariance. We also fitted a latent change-score model to the data. As expected, participants on average rated their memory as poorer at age 70 than at 40. Those who reported better overall health and less anxiety reported less memory decline up to age 70. Notably, this was also the case for those who rated memory as worse at age 40. Higher stress and depression at age 70, however, were associated with worse subjective memory already at age 40. The correspondences between memory ratings and tests were low. The correlation between the subjective memory factors at age 40 and 70 was 0.58, while the correlation between the memory factor at age 70 and the retrospective subjective memory factor was 0.87. Our findings suggest that subjective memory is quite consistent, and that we are inclined to preserve the continuity of our own memory functioning over the adult lifespan.

Sign in / Sign up

Export Citation Format

Share Document