Increased sodium plus potassium adenosine triphosphatase activity in erythrocyte membranes in Huntington's disease

1978 ◽  
Vol 4 (1) ◽  
pp. 60-62 ◽  
Author(s):  
D. A. Butterfield ◽  
J. Q. Oeswein ◽  
M. E. Prunty ◽  
K. C. Hisle ◽  
W. R. Markesbery
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Adenosine Triphosphatase ◽  
Erythrocyte Membranes ◽  
Adenosine Triphosphatase Activity

scholarly journals Studies on erythrocyte membranes of patients with Huntington's disease

1981 ◽  
Vol 44 (7) ◽  
pp. 570-573 ◽  
Author(s):  
T. M. Dubbelman ◽  
A. W D. Bruijne ◽  
J. V. Steveninck ◽  
G. W Bruyn
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Erythrocyte Membranes

BIOPHYSICAL STUDIES OF ERYTHROCYTE MEMBRANES IN HUNTINGTON'S DISEASE

1978 ◽  
pp. 101-107 ◽  
Author(s):  
D. Allan Butterfield ◽  
James Q. Oeswein ◽  
William R. Markesbery
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Erythrocyte Membranes ◽  
Biophysical Studies

Decreased Ouabain-Sensitive Adenosine Triphosphatase Activity in the Erythrocyte Membrane of Patients with Chronic Renal Disease

1973 ◽  
Vol 45 (6) ◽  
pp. 775-784 ◽  
Author(s):  
C. H. Cole
Keyword(s):  
Renal Disease ◽  
Erythrocyte Membrane ◽  
Adenosine Triphosphatase ◽  
Chronic Renal Disease ◽  
Sodium Concentration ◽  
Erythrocyte Membranes ◽  
General Medical Ward ◽  
Adenosine Triphosphatase Activity ◽  
Average Decrease ◽  
Erythrocyte Sodium

1. Ouabain-sensitive ATPase (adenosine triphosphatase) activity was measured in the erythrocyte membranes of twenty patients with chronic renal disease. Decreased activity was found in nineteen of the twenty patients. The average decrease was 38%. 2. In three patients erythrocyte sodium concentration exceeded 9·5 mmol/l of RBC and these patients had the most marked decreases in ouabain-sensitive ATPase activity. 3. By contrast, in only two of 100 patients admitted to a general medical ward was erythrocyte sodium concentration greater than 9.5 mmol/l of RBC. 4. Ouabain-insensitive and calcium-activated components of erythrocyte membrane ATPase were unaffected by chronic renal disease.

scholarly journals The influence of external sodium ions on the sodium pump in erythrocytes

1968 ◽  
Vol 109 (3) ◽  
pp. 369-374 ◽  
Author(s):  
R. N. Priestland ◽  
R. Whittam
Keyword(s):  
Adenosine Triphosphatase ◽  
Sodium Pump ◽  
Erythrocyte Membranes ◽  
Sodium Ions ◽  
Adenosine Triphosphatase Activity ◽  
Sensitive Site ◽  
Na Efflux ◽  
Ion Movements ◽  
K Concentration ◽  
External K

1. A study has been made of the interaction between Na+ and K+ on the adenosine triphosphatase activity of erythrocyte ‘ghosts’, and on the K+ influx and Na+ efflux of intact erythrocytes. The adenosine triphosphatase activity and the ion movements were greater at a low external K+ concentration in the absence of Na+ than they were in the presence of 150mm-Na+. The inhibition by external Na+ of K+ influx had an inhibitory constant of 5–10mm. 2. Activation by K+ of kidney microsomal adenosine triphosphatase was retarded by Na+, and activation by Na+ was retarded by K+. Fragmented erythrocyte membranes behaved similarly. 3. These observations suggest that there is competition between Na+ and K+ at the K+-sensitive site of the membrane.

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