Decreased Ouabain-Sensitive Adenosine Triphosphatase Activity in the Erythrocyte Membrane of Patients with Chronic Renal Disease

1973 ◽  
Vol 45 (6) ◽  
pp. 775-784 ◽  
Author(s):  
C. H. Cole
Keyword(s):  
Renal Disease ◽  
Erythrocyte Membrane ◽  
Adenosine Triphosphatase ◽  
Chronic Renal Disease ◽  
Sodium Concentration ◽  
Erythrocyte Membranes ◽  
General Medical Ward ◽  
Adenosine Triphosphatase Activity ◽  
Average Decrease ◽  
Erythrocyte Sodium

1. Ouabain-sensitive ATPase (adenosine triphosphatase) activity was measured in the erythrocyte membranes of twenty patients with chronic renal disease. Decreased activity was found in nineteen of the twenty patients. The average decrease was 38%. 2. In three patients erythrocyte sodium concentration exceeded 9·5 mmol/l of RBC and these patients had the most marked decreases in ouabain-sensitive ATPase activity. 3. By contrast, in only two of 100 patients admitted to a general medical ward was erythrocyte sodium concentration greater than 9.5 mmol/l of RBC. 4. Ouabain-insensitive and calcium-activated components of erythrocyte membrane ATPase were unaffected by chronic renal disease.

Changes in Erythrocyte Membrane Ouabain-Sensitive Adenosine Triphosphatase after Renal Transplantation

1975 ◽  
Vol 48 (3) ◽  
pp. 239-242 ◽  
Author(s):  
C. H. Cole ◽  
R. Maletz
Keyword(s):  
Renal Transplantation ◽  
Atpase Activity ◽  
Erythrocyte Membrane ◽  
Adenosine Triphosphatase ◽  
Inorganic Phosphorus ◽  
Erythrocyte Membranes ◽  
Healthy Controls ◽  
Intracellular Electrolytes ◽  
Transplant Patients ◽  
The Mean

1. Intracellular electrolytes, and erythrocyte membrane adenosine triphosphatase (ATPase) activity, was studied in twenty patients after renal transplantation. 2. The mean ouabain-sensitive ATPase activity in the erythrocyte membranes of the transplant patients was 122 nmol of inorganic phosphorus (Pi) h−1 mg of tissue−1 (sem 14), compared with 62 nmol of Pi h−1 mg of tissue−1 (sem 8) in a group of paired, healthy controls. 3. The increase in ouabain-sensitive ATPase was most marked in the 4 months after transplantation. However, a significant increase in ouabain-sensitive ATPase persisted for more than 8 months after transplantation. 4. This increase in ouabain-sensitive ATPase was associated with a decrease in intracellular sodium in the erythrocytes of the transplant patients.

Effect of Electroconvulsive Therapy on Erythrocyte Adenosine Triphosphatase Activity in Depressive Illness

1980 ◽  
Vol 137 (4) ◽  
pp. 343-345 ◽  
Author(s):  
L. J. Whalley ◽  
M. Scott ◽  
H. W. Reading ◽  
J. E. Christie
Keyword(s):  
Atpase Activity ◽  
Erythrocyte Membrane ◽  
Electroconvulsive Therapy ◽  
Healthy Subjects ◽  
Adenosine Triphosphatase ◽  
Depressive Illness ◽  
Slight Reduction ◽  
Acute Effects ◽  
Adenosine Triphosphatase Activity ◽  
Depressed Patients

SummaryErythrocyte membrane adenosine triphosphatase activities were examined in twelve unipolar depressed patients receiving ECT. Eleven patients undergoing diagnostic cystoscopy served as controls for the acute effects of anaesthesia, and sixteen healthy subjects served as non-depressed controls. The unipolar depressed patients had a slight reduction in their (Na++K+)-ATPase activity but effective ECT treatment was not associated with any increase in this activity. This approach is unlikely to cast further light on the membrane phenomenology of depressive illness.

Erythrocyte membrane cation carrier in depressive illness

1973 ◽  
Vol 3 (4) ◽  
pp. 502-508 ◽  
Author(s):  
G. J. Naylor ◽  
D. A. T. Dick ◽  
E. G. Dick ◽  
D. Le Poidevin ◽  
S. F. Whyte
Keyword(s):  
Atpase Activity ◽  
Erythrocyte Membrane ◽  
Potassium Concentration ◽  
Sodium Concentration ◽  
Depressive Mood ◽  
Depressive Illness ◽  
Mood Rating ◽  
Potassium Influx ◽  
Erythrocyte Sodium ◽  
Discharge From Hospital

SynopsisErythrocyte sodium concentration, potassium concentration, Na-K ATPase activity, and ouabain sensitive potassium influx were determined in female inpatients suffering from a depressive illness. In most patients the biochemical values were also determined shortly before the patient's discharge from hospital. The Na-K ATPase and the ouabain sensitive potassium influx increased significantly with improvement in the depressive mood rating.

Lithium and erythrocyte membrane cation carrier studies in normal and manic depressive subjects

1977 ◽  
Vol 7 (2) ◽  
pp. 229-233 ◽  
Author(s):  
G. J. Naylor ◽  
A. Smith ◽  
L. J. Boardman ◽  
D. A. T. Dick ◽  
E. G. Dick ◽  
...  
Keyword(s):  
Erythrocyte Membrane ◽  
Human Subjects ◽  
Normal Subjects ◽  
Sodium Concentration ◽  
Manic Depressive Psychosis ◽  
Manic Depressive ◽  
Normal Human ◽  
Potassium Influx ◽  
Erythrocyte Sodium

synopsisChanges in the erythrocyte membrane cation carrier following lithium ingestion in normal human subjects were studied; ouabain sensitive potassium influx fell significantly during the lithium treated phase. Lithium was fed to rats and no change in erythrocyte Na-K ATPase was shown. These findings contrast with studies of lithium in manic depressive psychosis. The fluctuations in the erythrocyte membrane cation carrier were studied in 5 normal subjects over 12 weeks and the correlations between the parameters calculated. The erythrocyte sodium concentration correlated positively with the ouabain sensitive potassium influx. This too contrasts with findings in manic depressive psychosis.

scholarly journals The influence of external sodium ions on the sodium pump in erythrocytes

1968 ◽  
Vol 109 (3) ◽  
pp. 369-374 ◽  
Author(s):  
R. N. Priestland ◽  
R. Whittam
Keyword(s):  
Adenosine Triphosphatase ◽  
Sodium Pump ◽  
Erythrocyte Membranes ◽  
Sodium Ions ◽  
Adenosine Triphosphatase Activity ◽  
Sensitive Site ◽  
Na Efflux ◽  
Ion Movements ◽  
K Concentration ◽  
External K

1. A study has been made of the interaction between Na+ and K+ on the adenosine triphosphatase activity of erythrocyte ‘ghosts’, and on the K+ influx and Na+ efflux of intact erythrocytes. The adenosine triphosphatase activity and the ion movements were greater at a low external K+ concentration in the absence of Na+ than they were in the presence of 150mm-Na+. The inhibition by external Na+ of K+ influx had an inhibitory constant of 5–10mm. 2. Activation by K+ of kidney microsomal adenosine triphosphatase was retarded by Na+, and activation by Na+ was retarded by K+. Fragmented erythrocyte membranes behaved similarly. 3. These observations suggest that there is competition between Na+ and K+ at the K+-sensitive site of the membrane.

Increased sodium plus potassium adenosine triphosphatase activity in erythrocyte membranes in Huntington's disease

1978 ◽  
Vol 4 (1) ◽  
pp. 60-62 ◽  
Author(s):  
D. A. Butterfield ◽  
J. Q. Oeswein ◽  
M. E. Prunty ◽  
K. C. Hisle ◽  
W. R. Markesbery
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Adenosine Triphosphatase ◽  
Erythrocyte Membranes ◽  
Adenosine Triphosphatase Activity

scholarly journals Effects of derivatives of hydroxypyruvaldehyde phenylosazone on the Ca2+-adenosine triphosphatase activity of porcine erythrocyte membrane.

1985 ◽  
Vol 33 (8) ◽  
pp. 3510-3513
Author(s):  
TOSHIKATSU NAKABAYASHI ◽  
HIROH IKEZAWA ◽  
HARUKI OGAWA ◽  
MINORU SHINDO ◽  
ISAO MATSUNAGA
Keyword(s):  
Erythrocyte Membrane ◽  
Adenosine Triphosphatase ◽  
Adenosine Triphosphatase Activity ◽  
Derivatives Of ◽  
Porcine Erythrocyte
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