Complementary Sequence Preferences of Electron-Capture Dissociation and Vibrational Excitation in Fragmentation of Polypeptide Polycations

2006 ◽  
Vol 45 (32) ◽  
pp. 5301-5303 ◽  
Author(s):  
Mikhail M. Savitski ◽  
Frank Kjeldsen ◽  
Michael L. Nielsen ◽  
Roman A. Zubarev
Keyword(s):  
Electron Capture ◽  
Electron Capture Dissociation ◽  
Vibrational Excitation ◽  
Complementary Sequence

Complementary Sequence Preferences of Electron-Capture Dissociation and Vibrational Excitation in Fragmentation of Polypeptide Polycations

2006 ◽  
Vol 118 (32) ◽  
pp. 5427-5429 ◽  
Author(s):  
Mikhail M. Savitski ◽  
Frank Kjeldsen ◽  
Michael L. Nielsen ◽  
Roman A. Zubarev
Keyword(s):  
Electron Capture ◽  
Electron Capture Dissociation ◽  
Vibrational Excitation ◽  
Complementary Sequence

Dob-ions occur from vibrational excitation upon H-desorption in electron capture dissociation?

2007 ◽  
Vol 21 (6) ◽  
pp. 1003-1008 ◽  
Author(s):  
Kim F. Haselmann ◽  
Marcel Schmidt
Keyword(s):  
Electron Capture ◽  
Electron Capture Dissociation ◽  
Vibrational Excitation

Electron Capture Dissociation and Infrared Multiphoton Dissociation MS/MS of an N-Glycosylated Tryptic Peptide To Yield Complementary Sequence Information

2001 ◽  
Vol 73 (18) ◽  
pp. 4530-4536 ◽  
Author(s):  
Kristina Håkansson ◽  
Helen J. Cooper ◽  
Mark R. Emmett ◽  
Catherine E. Costello ◽  
Alan G. Marshall ◽  
...  
Keyword(s):  
Electron Capture ◽  
Electron Capture Dissociation ◽  
Tryptic Peptide ◽  
Infrared Multiphoton Dissociation ◽  
Sequence Information ◽  
Complementary Sequence ◽  
Multiphoton Dissociation

scholarly journals Electron Capture Dissociation, Electron Detachment Dissociation and Infrared Multiphoton Dissociation of Sucrose Octasulfate

2009 ◽  
Vol 15 (2) ◽  
pp. 275-281 ◽  
Author(s):  
Jeremy J. Wolff ◽  
Tatiana N. Laremore ◽  
Franklin E. Leach ◽  
Robert J. Linhardt ◽  
I. Jonathan Amster
Keyword(s):  
Mass Spectrometry ◽  
Electron Capture ◽  
Electron Capture Dissociation ◽  
Vibrational Excitation ◽  
Infrared Multiphoton Dissociation ◽  
Electron Detachment Dissociation ◽  
Electron Detachment ◽  
Sucrose Octasulfate ◽  
Product Ions ◽  
Multiphoton Dissociation

The structural analysis of sulfated carbohydrates such as glycosaminoglycans (GAGs) has been a long-standing challenge for the field of mass spectrometry. The dissociation of sulfated carbohydrates by collisionally-activated dissociation (CAD) or infrared multiphoton dissociation (IRMPD), which activate ions via vibrational excitation, typically result in few cleavages and abundant SO3 loss for highly sulfated GAGs such as heparin and heparan sulfate, hampering efforts to determine sites of modification. The recent application of electron activation techniques, specifically electron capture dissociation (ECD) and electron detachment dissociation (EDD), provides a marked improvement for the mass spectrometry characterization of GAGs. In this work, we compare ECD, EDD and IRMPD for the dissociation of the highly sulfated carbohydrate sucrose octasulfate (SOS). Both positive and negative multiply-charged ions are investigated. ECD, EDD and IRMPD of SOS produce abundant and reproducible fragmentation. The product ions produced by ECD are quite different than those produced by IRMPD of SOS positive ions, suggesting different dissociation mechanisms as a result of electronic versus vibrational excitation. The product ions produced by EDD and IRMPD of SOS negative ions also differ from each other. Evidence for SO3 rearrangement exists in the negative ion IRMPD data, complicating the assignment of product ions.

scholarly journals Proteoform Differentiation using Tandem Trapped Ion Mobility, Electron Capture Dissociation, and ToF Mass Spectrometry

2021 ◽  
Author(s):  
Kevin Jeanne Dit Fouque ◽  
Desmond Kaplan ◽  
Valery G. Voinov ◽  
Frederik H. V. Holck ◽  
Ole N. Jensen ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Electron Capture ◽  
Electron Capture Dissociation ◽  
Ion Mobility ◽  
Trapped Ion

Negative-Ion Electron Capture Dissociation: Radical-Driven Fragmentation of Charge-Increased Gaseous Peptide Anions

2011 ◽  
Vol 133 (42) ◽  
pp. 16790-16793 ◽  
Author(s):  
Hyun Ju Yoo ◽  
Ning Wang ◽  
Shuyi Zhuang ◽  
Hangtian Song ◽  
Kristina Håkansson
Keyword(s):  
Electron Capture ◽  
Electron Capture Dissociation ◽  
Negative Ion ◽  
Peptide Anions

scholarly journals Electron Capture Dissociation Implementation Progress in Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

2008 ◽  
Vol 19 (6) ◽  
pp. 762-771 ◽  
Author(s):  
Yury O. Tsybin ◽  
John P. Quinn ◽  
Oleg Yu Tsybin ◽  
Christopher L. Hendrickson ◽  
Alan G. Marshall
Keyword(s):  
Mass Spectrometry ◽  
Fourier Transform ◽  
Electron Capture ◽  
Electron Capture Dissociation ◽  
Cyclotron Resonance ◽  
Ion Cyclotron Resonance ◽  
Ion Cyclotron ◽  
Implementation Progress
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