scholarly journals Complementary Strategies for Directed C(sp3)−H Functionalization: A Comparison of Transition-Metal-Catalyzed Activation, Hydrogen Atom Transfer, and Carbene/Nitrene Transfer

2017 ◽  
Vol 57 (1) ◽  
pp. 62-101 ◽  
Author(s):  
John C. K. Chu ◽  
Tomislav Rovis
Keyword(s):  
Hydrogen Atom ◽  
Transition Metal ◽  
Hydrogen Atom Transfer ◽  
Atom Transfer ◽  
Nitrene Transfer ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

Direct Cyclization of Alkenyl Thioester via Transition Metal‐hydrogen Atom Transfer/radical‐polar Crossover Mechanism

2019 ◽  
Author(s):  
Shiori Date ◽  
Kensei Hamasaki ◽  
Karen Sunagawa ◽  
Hiroki Koyama ◽  
Chikayoshi Sebe ◽  
...  
Keyword(s):  
Natural Products ◽  
Hydrogen Atom ◽  
Transition Metal ◽  
Hydrogen Atom Transfer ◽  
Synthetic Method ◽  
Atom Transfer ◽  
Reaction Conditions ◽  
Hydride Hydrogen ◽  
Sulfur Heterocycles ◽  
One Step

<div>We report here a catalytic, Markovnikov selective, and scalable synthetic method for the synthesis of saturated sulfur heterocycles, which are found in the structures of pharmaceuticals and natural products, in one step from an alkenyl thioester. Unlike a potentially labile alkenyl thiol, an alkenyl thioester is stable and easy to prepare. The powerful Co catalysis via a cobalt hydride hydrogen atom transfer and radical-polar crossover mechanism enabled simultaneous cyclization and deprotection. The substrate scope was expanded by the extensive optimization of the reaction conditions and tuning of the thioester unit.</div>

scholarly journals Trends in Ground-State Entropies for Transition Metal Based Hydrogen Atom Transfer Reactions

2009 ◽  
Vol 131 (12) ◽  
pp. 4335-4345 ◽  
Author(s):  
Elizabeth A. Mader ◽  
Virginia W. Manner ◽  
Todd F. Markle ◽  
Adam Wu ◽  
James A. Franz ◽  
...  
Keyword(s):  
Hydrogen Atom ◽  
Transition Metal ◽  
Ground State ◽  
Hydrogen Atom Transfer ◽  
Transfer Reactions ◽  
Atom Transfer ◽  
Atom Transfer Reactions

Transition-metal-free radical relay cyclization of vinyl azides with 1,4-dihydropyridines involving a 1,5-hydrogen-atom transfer: access to α-tetralone scaffolds

2020 ◽  
Vol 7 (22) ◽  
pp. 3638-3647
Author(s):  
Yangzhen Liao ◽  
Yu Ran ◽  
Guijun Liu ◽  
Peijun Liu ◽  
Xiaozu Liu
Keyword(s):  
Free Radical ◽  
Hydrogen Atom ◽  
Transition Metal ◽  
Hydrogen Atom Transfer ◽  
Atom Transfer ◽  
Metal Free ◽  
Vinyl Azides

The remote C(sp3)–H functionalization enabled by a radical-mediated 1,5-hydrogen-atom transfer (HAT) process using vinyl azides and 1,4-dihydropyridines as precursors has been described.

scholarly journals Investigation of transition metal-catalyzed nitrene transfer reactions in water

2018 ◽  
Vol 26 (19) ◽  
pp. 5270-5273 ◽  
Author(s):  
Juliet M. Alderson ◽  
Joshua R. Corbin ◽  
Jennifer M. Schomaker
Keyword(s):  
Transition Metal ◽  
Transfer Reactions ◽  
Nitrene Transfer ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed
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