Isolable Silylene Ligands Can Boost Efficiencies and Selectivities in Metal‐Mediated Catalysis

2019 ◽  
Vol 58 (12) ◽  
pp. 3715-3728 ◽  
Author(s):  
Yu‐Peng Zhou ◽  
Matthias Driess
Keyword(s):  
Mediated Catalysis

scholarly journals The Profound Influence of Lipid Composition on the Catalysis of the Drug Target NADH Type II Oxidoreductase

Membranes ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 363
Author(s):  
Albert Godoy-Hernandez ◽  
Duncan G. G. McMillan
Keyword(s):  
Acyl Chain ◽  
Cellular Respiration ◽  
Type Ii ◽  
Nadh:Quinone Oxidoreductase ◽  
Chain Composition ◽  
Membrane Bound ◽  
Lipid Environment ◽  
Lipid Specificity ◽  
Mediated Catalysis ◽  
Quinone Pool

Lipids play a pivotal role in cellular respiration, providing the natural environment in which an oxidoreductase interacts with the quinone pool. To date, it is generally accepted that negatively charged lipids play a major role in the activity of quinone oxidoreductases. By changing lipid compositions when assaying a type II NADH:quinone oxidoreductase, we demonstrate that phosphatidylethanolamine has an essential role in substrate binding and catalysis. We also reveal the importance of acyl chain composition, specifically c14:0, on membrane-bound quinone-mediated catalysis. This demonstrates that oxidoreductase lipid specificity is more diverse than originally thought and that the lipid environment plays an important role in the physiological catalysis of membrane-bound oxidoreductases.

The First Thiadiazolidine 1-Oxide System for Phosphine-Free Palladium-Mediated Catalysis

2009 ◽  
Vol 351 (1-2) ◽  
pp. 71-77 ◽  
Author(s):  
Benjamin R. Buckley ◽  
Stephen P. Neary
Keyword(s):  
Oxide System ◽  
Mediated Catalysis

scholarly journals Thiadiazolidine 1-oxide systems for phosphine-free palladium-mediated catalysis

Tetrahedron ◽  
2010 ◽  
Vol 66 (40) ◽  
pp. 7988-7994 ◽  
Author(s):  
Benjamin R. Buckley ◽  
Stephen P. Neary
Keyword(s):  
Oxide Systems ◽  
Mediated Catalysis

Coupling Solar Energy into Reactions: Materials Design for Surface Plasmon-Mediated Catalysis

Small ◽  
2015 ◽  
Vol 11 (32) ◽  
pp. 3873-3889 ◽  
Author(s):  
Ran Long ◽  
Yu Li ◽  
Li Song ◽  
Yujie Xiong
Keyword(s):  
Solar Energy ◽  
Surface Plasmon ◽  
Materials Design ◽  
Mediated Catalysis

scholarly journals CD38 produces nicotinic acid adenosine dinucleotide phosphate in the lysosome

2018 ◽  
Vol 293 (21) ◽  
pp. 8151-8160 ◽  
Author(s):  
Cheng Fang ◽  
Ting Li ◽  
Ying Li ◽  
Guan Jie Xu ◽  
Qi Wen Deng ◽  
...  
Keyword(s):  
Nicotinic Acid ◽  
Biological Activities ◽  
Enzyme Activation ◽  
Acidic Ph ◽  
Human Cell Lines ◽  
Specific Expression ◽  
Wide Range ◽  
Reliable Mechanism ◽  
Mediated Catalysis ◽  
Dependent Pathway

Nicotinic acid adenosine dinucleotide phosphate (NAADP) is a Ca2+-mobilizing second messenger that regulates a wide range of biological activities. However, the mechanism of its biogenesis remains controversial. CD38 is the only enzyme known to catalyze NAADP synthesis from NADP and nicotinic acid. CD38-mediated catalysis requires an acidic pH, suggesting that NAADP may be produced in acidic endolysosomes, but this hypothesis is untested. In this study, using human cell lines, we specifically directed CD38 to the endolysosomal system and assessed cellular NAADP production. First, we found that nanobodies targeting various epitopes on the C-terminal domain of CD38 could bind to cell surface–localized CD38 and induce its endocytosis. We also found that CD38 internalization occurred via a clathrin-dependent pathway, delivered CD38 to the endolysosome, and elevated intracellular NAADP levels. We also created a CD38 variant for lysosome-specific expression, which not only withstood the degradative environment in the lysosome, but was also much more active than WT CD38 in elevating cellular NAADP levels. Supplementing CD38-expressing cells with nicotinic acid substantially increased cellular NAADP levels. These results demonstrate that endolysosomal CD38 can produce NAADP in human cells. They further suggest that CD38's compartmentalization to the lysosome may allow for its regulation via substrate access, rather than enzyme activation, thereby providing a reliable mechanism for regulating cellular NAADP production.

Network-supported, metal-mediated catalysis: progress and perspective

2020 ◽  
Vol 5 (10) ◽  
pp. 1892-1902
Author(s):  
Jeffrey A. Bennett ◽  
Bradley A. Davis ◽  
Kirill Efimenko ◽  
Jan Genzer ◽  
Milad Abolhasani
Keyword(s):  
Supported Catalysts ◽  
Catalytic Reactions ◽  
Wide Range ◽  
Recent Developments ◽  
Mediated Catalysis ◽  
Supported Metal

This minireview focuses on recent developments of network-supported catalysts to improve the performance of a wide range of metal-mediated catalytic reactions.

New cobalt(ii) coordination designs and the influence of varying chelate characters, ligand charges and incorporated group I metal ions on enzyme-like oxidative coupling activity

2020 ◽  
Vol 44 (35) ◽  
pp. 14849-14858
Author(s):  
Hammed Olawale Oloyede ◽  
Joseph Anthony Orighomisan Woods ◽  
Helmar Görls ◽  
Winfried Plass ◽  
Abiodun Omokehinde Eseola
Keyword(s):  
Transition Metal ◽  
Metal Ions ◽  
Active Site ◽  
Oxidative Coupling ◽  
Reaction Conditions ◽  
Group I ◽  
Mediated Catalysis

In transition-metal-mediated catalysis, design of new, well defined coordination architectures and subjecting them to catalysis testing under the same reaction conditions is a necessity tool for improved understanding of desirable active site geometries and characteristics.

Adaptation of thermophilic acetyltransferase to a water-mediated catalytic mechanism

2020 ◽  
Vol 56 (72) ◽  
pp. 10537-10540
Author(s):  
Yu-Yung Chang ◽  
Sora Hagawa ◽  
Chun-Hua Hsu
Keyword(s):  
Catalytic Mechanism ◽  
Mediated Catalysis ◽  
Better Than

Two is better than one: thermophilic Nα-acetyltransferase SsArd1 develops a strategy to adapt to higher temperatures for water-mediated catalysis.

Lisicon Glass-Ceramics Mediated Catalysis of Oxygen Reduction

2011 ◽  
Vol 14 (6) ◽  
pp. A97 ◽  
Author(s):  
Binod Kumar ◽  
Padmakar Kichambare ◽  
Stanley Rodrigues ◽  
Jitendra Kumar ◽  
Robert G. Keil
Keyword(s):  
Oxygen Reduction ◽  
Glass Ceramics ◽  
Mediated Catalysis

Dearomative Dienolate-Mediated Catalysis: A Remote Activation Strategy for Asymmetric Functionalization of Benzylic C–H Bonds of Heteroaryl Aldehydes

2018 ◽  
Vol 20 (18) ◽  
pp. 5835-5839 ◽  
Author(s):  
Yang Wang ◽  
Jun-Bing Lin ◽  
Ji-Kang Xie ◽  
Hong Lu ◽  
Xiu-Qin Hu ◽  
...  
Keyword(s):  
Mediated Catalysis
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