Synthesis of a series of boronated unnatural cyclic amino acids as potential boron neutron capture therapy agents

2008 ◽  
Vol 22 (9) ◽  
pp. 516-522 ◽  
Author(s):  
George W. Kabalka ◽  
Zhongzhi Wu ◽  
Min-Liang Yao
Keyword(s):  
Amino Acids ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture ◽  
Cyclic Amino Acids

Biological Evaluation of Dodecaborate-Containing l-Amino Acids for Boron Neutron Capture Therapy

2012 ◽  
Vol 55 (15) ◽  
pp. 6980-6984 ◽  
Author(s):  
Yoshihide Hattori ◽  
Shintaro Kusaka ◽  
Mari Mukumoto ◽  
Kouki Uehara ◽  
Tomoyuki Asano ◽  
...  
Keyword(s):  
Amino Acids ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Biological Evaluation ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture

scholarly journals HGG-05. REGRESSION OF RECURRENT GLIOBLASTOMA AFTER BORON NEUTRON CAPTURE THERAPY AND CHIMERIC ANTIGEN RECEPTOR T-CELL THERAPY IN A CHILD

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii345-iii345
Author(s):  
Hsin-Hung Chen ◽  
Yi-Wei Chen
Keyword(s):  
T Cells ◽  
T Cell ◽  
Chimeric Antigen Receptor ◽  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Antigen Receptor ◽  
Neutron Capture Therapy ◽  
T Cell Therapy ◽  
Boron Neutron Capture ◽  
Car T

Abstract A 6 y/o girl with recurrent multifocal glioblastoma received 3 times of boron neutron capture therapy (BNCT) and chimeric antigen receptor (CAR)–engineered T cells targeting the tumor-associated antigen HER2. Multiple infusions of CAR T cells were administered over 30 days through intraventricular delivery routes. It was not associated with any toxic effects of grade 3 or higher. After BNCT and CAR T-cell treatment, regression of all existing intracranial lesions were observed, along with corresponding increases in levels of cytokines and immune cells in the cerebrospinal fluid, but new lesions recurred soon after the treatment. This clinical response continued for 14 months after the initiation of first recurrence.

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