Systematic Review and Meta‐Analysis of Bioaerosol Emission During Orthopedic Surgical Procedures: Coronavirus Considerations

Background Orthopedic surgical procedures involve a number of aerosol generating procedures; these include electrocautery, power instruments for bone cutting, burring and drilling, and tools for wound lavage. This assumes a great significance in the context of the current COVD-19 pandemic, as there are chances of aerosol-borne disease transmission in orthopedic surgical procedures. Hence, this systematic review and meta-analysis will be undertaken to assimilate and analyse the available evidence on bioaerosols in orthopedic surgical procedures and their significance with respect to SARS-CoV-2 virus transmission. Objectives To determine the characteristics (amount and/or density, size, infectivity, and spread etc.) of bioaerosols found in orthopaedic operating rooms (ORs) and to determine the characteristics of aerosols generated by different orthopaedic power tools and devices. Methods A systematic review and meta-analysis will be conducted. The PRISMA guidelines will be strictly followed. The primary search will be conducted on the PubMed, EMBASE, Scopus, Cochrane Library, medRxiv, bioRxix and Lancet preprint databases, using a well-defined search strategy. Any original research study (including cohort, case-control, case series, cadaveric studies and studies, animal models, laboratory based experimental studies) looking at aerosol generation in orthopedic surgical procedures, or aerosol generation by orthopaedic power tools and devices will included. Outcome measures will include characteristics (amount and/or density, size, infectivity, and spread etc.) of bioaerosols found in orthopaedic operating rooms (ORs) and those generated by various orthopaedics power tools and devices. Metanalysis using the random-effects model will be conducted to determined pooled estimates of the outcome variables. Heterogeneity will be assessed by the I2 test. Risk of bias will be assessed by the Risk of Bias in Studies estimating Prevalence of Exposure to Occupational risk factors (RoB-SPEO) tool. The overall strength of evidence will be assessed by the GRADE approach.

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Peer review report 1 on “Decompression and coflex interlaminar stabilisation compared with conventional surgical procedures for lumbar spinal stenosis: A systematic review and meta-analysis”

International Journal of Surgery ◽

10.1016/j.ijsu.2017.02.089 ◽

2017 ◽

Vol 37 ◽

pp. 226

Author(s):

Dattatraya Muzumdar

Keyword(s):

Systematic Review ◽

Peer Review ◽

Spinal Stenosis ◽

Lumbar Spinal Stenosis ◽

Surgical Procedures ◽

Meta Analysis ◽

Lumbar Spinal

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SHORT-TERM EFFECTIVENESS OF THE THREE MOST COMMONLY PERFORMED BARIATRIC SURGICAL PROCEDURES: A SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS

Value in Health ◽

10.1016/j.jval.2016.03.1082 ◽

2016 ◽

Vol 19 (3) ◽

pp. A242

Author(s):

J. Lee ◽

Q. Le

Keyword(s):

Systematic Review ◽

Randomized Controlled Trials ◽

Surgical Procedures ◽

Meta Analysis ◽

Controlled Trials ◽

Short Term ◽

Randomized Controlled

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Outcomes of cardiac surgical procedures performed by trainees versus consultants: a systematic review with meta-analysis

Journal of Thoracic and Cardiovascular Surgery ◽

10.1016/j.jtcvs.2021.12.029 ◽

2021 ◽

Author(s):

Antonio C. Escorel Neto ◽

Michel Pompeu Sá ◽

Jef Van den Eynde ◽

Hajar Rotbi ◽

Chi Chi Do-Nguyen ◽

...

Keyword(s):

Systematic Review ◽

Surgical Procedures ◽

Meta Analysis ◽

Cardiac Surgical Procedures

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Complications of Tranexamic Acid in Orthopedic Lower Limb Surgery: A Meta-Analysis of Randomized Controlled Trials

BioMed Research International ◽

10.1155/2021/6961540 ◽

2021 ◽

Vol 2021 ◽

pp. 1-14

Author(s):

Davide Reale ◽

Luca Andriolo ◽

Safa Gursoy ◽

Murat Bozkurt ◽

Giuseppe Filardo ◽

...

Keyword(s):

Tranexamic Acid ◽

Surgical Procedures ◽

Lower Limb ◽

Cruciate Ligament ◽

Meta Analysis ◽

Orthopedic Procedures ◽

Cochrane Library ◽

Complication Rates ◽

Administration Route ◽

Orthopedic Surgical Procedures

Objective. Tranexamic acid (TXA) is increasingly used in orthopedic surgery to reduce blood loss; however, there are concerns about the risk of venous thromboembolic (VTE) complications. The aim of this study was to evaluate TXA safety in patients undergoing lower limb orthopedic surgical procedures. Design. A meta-analysis was performed on the PubMed, Web of Science, and Cochrane Library databases in January 2020 using the following string (Tranexamic acid) AND ((knee) OR (hip) OR (ankle) OR (lower limb)) to identify RCTs about TXA use in patients undergoing every kind of lower limb surgical orthopedic procedures, with IV, IA, or oral administration, and compared with a control arm to quantify the VTE complication rates. Results. A total of 140 articles documenting 9,067 patients receiving TXA were identified. Specifically, 82 studies focused on TKA, 41 on THA, and 17 on other surgeries, including anterior cruciate ligament reconstruction, intertrochanteric fractures, and meniscectomies. The intravenous TXA administration protocol was studied in 111 articles, the intra-articular in 45, and the oral one in 7 articles. No differences in terms of thromboembolic complications were detected between the TXA and control groups neither in the overall population (2.4% and 2.8%, respectively) nor in any subgroup based on the surgical procedure and TXA administration route. Conclusions. There is an increasing interest in TXA use, which has been recently broadened from the most common joint replacement procedures to the other types of surgeries. Overall, TXA did not increase the risk of VTE complications, regardless of the administration route, thus supporting the safety of using TXA for lower limb orthopedic surgical procedures.

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