Evaluation of alginate dialdehyde as a suitable crosslinker on modifying porcine acellular dermal matrix: The aggregation of collagenous fibers

2016 ◽  
Vol 133 (25) ◽  
Author(s):  
Shichen Zhu ◽  
Zhipeng Gu ◽  
Yang Hu ◽  
Weihua Dan ◽  
Shanbai Xiong
Keyword(s):  
Acellular Dermal Matrix ◽  
Dermal Matrix ◽  
Porcine Acellular Dermal Matrix ◽  
Acellular Dermal ◽  
Collagenous Fibers

Porcine Acellular Dermal Matrix Modified by N-(2-Hydroxy) Propyl-3-Trimethyl Ammonium Chitosan Chloride

2012 ◽  
Vol 550-553 ◽  
pp. 1413-1418
Author(s):  
Nian Hua Dan ◽  
Jian Zhu ◽  
Wei Hua Dan ◽  
Shi Wei Xiao
Keyword(s):  
Escherichia Coli ◽  
Contact Angle ◽  
Antibacterial Properties ◽  
Acellular Dermal Matrix ◽  
Dermal Matrix ◽  
Before And After ◽  
Porcine Acellular Dermal Matrix ◽  
Acellular Dermal ◽  
And Staphylococcus Aureus ◽  
Varied Concentration

Porcine acellular dermal matrix (pADM) was modified by N-(2-Hydroxy) propyl-3-Trimethyl Ammonium Chitosan Chloride (HTCC) with varied concentration, pH, time and temperature. The absorption of HTCC, surface state, hydrophilicity, antibacterial properties and cytotoxicity of pADM were researched before and after modification. Results show that the optimum experimental condition of modification is pH 6.4, 37°C, treated for 48 hours, and the concentration of HTCC 0.7%. The contact angle of modified pADM reduces and the water absorption ratio increases, but the tensile strength and moisture permeability falls. Obvious antibacterial action is observed on Escherichia Coli and Staphylococcus Aureus, and cytotoxicity is grade 2. This work suggests the feasibility of HTCC to modify pADM.

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