Poly(ethylene glycol)‐interpenetrated genipin‐crosslinked chitosan hydrogels: Structure, pH responsiveness, gelation kinetics, and rheology

2020 ◽  
Vol 137 (41) ◽  
pp. 49259
Author(s):  
Nga T. N. Vo ◽  
Lei Huang ◽  
Henrique Lemos ◽  
Andrew Mellor ◽  
Katarina Novakovic
Keyword(s):  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Gelation Kinetics ◽  
Crosslinked Chitosan ◽  
Poly Ethylene ◽  
Chitosan Hydrogels

Assessment of reinforced poly(ethylene glycol) chitosan hydrogels as dressings in a mouse skin wound defect model

2013 ◽  
Vol 33 (5) ◽  
pp. 2584-2594 ◽  
Author(s):  
Szu-Hsien Chen ◽  
Ching-Ting Tsao ◽  
Chih-Hao Chang ◽  
Yi-Ting Lai ◽  
Ming-Fung Wu ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Mouse Skin ◽  
Skin Wound ◽  
Poly Ethylene Glycol ◽  
Defect Model ◽  
Glycol Chitosan ◽  
Poly Ethylene ◽  
Chitosan Hydrogels

scholarly journals Regulating the Homogeneity of Thiol-Maleimide Michael-Type Addition-Based Hydrogels Using Amino Biomolecules

Gels ◽  
2021 ◽  
Vol 7 (4) ◽  
pp. 206
Author(s):  
Yu Guo ◽  
Jie Gu ◽  
Yuxin Jiang ◽  
Yanyan Zhou ◽  
Zhenshu Zhu ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Reaction Rate ◽  
Side Chain ◽  
Short Peptides ◽  
Poly Ethylene Glycol ◽  
Fast Reaction ◽  
Gelation Kinetics ◽  
Michael Type Addition ◽  
Poly Ethylene ◽  
Kinetics Of

Poly(ethylene glycol) (PEG)-based synthetic hydrogels based on Michael-type addition reaction have been widely used for cell culture and tissue engineering. However, recent studies showed that these types of hydrogels were not homogenous as expected since micro domains generated due to the fast reaction kinetics. Here, we demonstrated a new kind of method to prepare homogenous poly(ethylene glycol) hydrogels based on Michael-type addition using the side chain amine-contained short peptides. By introducing such a kind of short peptides, the homogeneity of crosslinking and mechanical property of the hydrogels has been also significantly enhanced. The compressive mechanical and recovery properties of the homogeneous hydrogels prepared in the presence of side chain amine-contained short peptides were more reliable than those of inhomogeneous hydrogels while the excellent biocompatibility remained unchanged. Furthermore, the reaction rate and gelation kinetics of maleimide- and thiol-terminated PEG were proved to be significantly slowed down in the presence of the side chain amine-contained short peptides, thus leading to the improved homogeneity of the hydrogels. We anticipate that this new method can be widely applied to hydrogel preparation and modification based on Michael-type addition gelation.

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