scholarly journals Garcinol from Garcinia indica inhibits HIV‐1 reverse transcriptase‐associated ribonuclease H

2021 ◽  
Author(s):  
Angela Corona ◽  
Sebastian Seibt ◽  
David Schaller ◽  
Rainer Schobert ◽  
Andrea Volkamer ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Ribonuclease H ◽  
Garcinia Indica ◽  
Hiv 1

scholarly journals Pyrrolyl Pyrazoles as Non-Diketo Acid Inhibitors of the HIV-1 Ribonuclease H Function of Reverse Transcriptase

2020 ◽  
Vol 11 (5) ◽  
pp. 798-805 ◽  
Author(s):  
Antonella Messore ◽  
Angela Corona ◽  
Valentina Noemi Madia ◽  
Francesco Saccoliti ◽  
Valeria Tudino ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Ribonuclease H ◽  
Hiv 1

Drug Targeting of HIV-1 RNA·DNA Hybrid Structures:  Thermodynamics of Recognition and Impact on Reverse Transcriptase-Mediated Ribonuclease H Activity and Viral Replication†

Biochemistry ◽  
2004 ◽  
Vol 43 (30) ◽  
pp. 9732-9742 ◽  
Author(s):  
Tsai-Kun Li ◽  
Christopher M. Barbieri ◽  
Hsin-Chin Lin ◽  
Arnold B. Rabson ◽  
Gengcheng Yang ◽  
...  
Keyword(s):  
Viral Replication ◽  
Reverse Transcriptase ◽  
Drug Targeting ◽  
Hybrid Structures ◽  
Ribonuclease H ◽  
Hiv 1

Prediction of the binding mode and resistance profile for a dual-target pyrrolyl diketo acid scaffold against HIV-1 integrase and reverse-transcriptase-associated ribonuclease H

2018 ◽  
Vol 20 (37) ◽  
pp. 23873-23884 ◽  
Author(s):  
Fengyuan Yang ◽  
Guoxun Zheng ◽  
Tingting Fu ◽  
Xiaofeng Li ◽  
Gao Tu ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Reverse Transcriptase ◽  
Binding Mode ◽  
Hiv Treatment ◽  
Rnase H ◽  
Ribonuclease H ◽  
Resistance Profile ◽  
Anti Hiv ◽  
Hiv 1 ◽  
Dual Target

The recently developed pyrrolyl diketo acid scaffold targeting both HIV-1 IN and RNase H is beneficial to counteract the failure of anti-HIV treatment due to drug resistance.

Recombinant HIV-1 reverse transcriptase: Purification, primary structure, and polymerase/ribonuclease H activities

1989 ◽  
Vol 273 (2) ◽  
pp. 347-358 ◽  
Author(s):  
Valerie Mizrahi ◽  
Gary M. Lazarus ◽  
Lynette M. Miles ◽  
Chester A. Meyers ◽  
Christine Debouck
Keyword(s):  
Reverse Transcriptase ◽  
Primary Structure ◽  
Ribonuclease H ◽  
Hiv 1

Transient kinetic analyses of the ribonuclease H cleavage activity of HIV-1 reverse transcriptase in complex with efavirenz and/or a β-thujaplicinol analogue

2013 ◽  
Vol 455 (2) ◽  
pp. 179-184 ◽  
Author(s):  
Brian D. Herman ◽  
Nicolas Sluis-Cremer
Keyword(s):  
Steady State ◽  
Reverse Transcriptase ◽  
Rnase H ◽  
Ribonuclease H ◽  
Cleavage Activity ◽  
Steady State Kinetics ◽  
Hiv 1

Pre-steady-state kinetics were used to define the mechanisms by which efavirenz and a β-thujaplicinol analogue modulate the RNase H activity of HIV-1 reverse transcriptase. Both inhibitors do not affect polymerase-dependent cleavages, but significantly affect the rates of polymerase-independent cleavages.

scholarly journals Structure–Activity Relationship of Pyrrolyl Diketo Acid Derivatives as Dual Inhibitors of HIV-1 Integrase and Reverse Transcriptase Ribonuclease H Domain

2015 ◽  
Vol 58 (4) ◽  
pp. 1915-1928 ◽  
Author(s):  
Giuliana Cuzzucoli Crucitti ◽  
Mathieu Métifiot ◽  
Luca Pescatori ◽  
Antonella Messore ◽  
Valentina Noemi Madia ◽  
...  
Keyword(s):  
Reverse Transcriptase ◽  
Structure Activity Relationship ◽  
Ribonuclease H ◽  
Activity Relationship ◽  
Structure Activity ◽  
Dual Inhibitors ◽  
Relationship Of ◽  
Hiv 1
Sign in / Sign up

Export Citation Format

Share Document