One-pot Chemoenzymatic Synthesis of Chiral 1,3-Diols Using an Enantioselective Aldol Reaction with Chiral Zn2+ Complex Catalysts and Enzymatic Reduction Using Oxidoreductases with Cofactor Regeneration

2011 ◽  
Vol 7 (1) ◽  
pp. 64-74 ◽  
Author(s):  
Shotaro Sonoike ◽  
Toshinari Itakura ◽  
Masanori Kitamura ◽  
Shin Aoki
Keyword(s):  
Aldol Reaction ◽  
Cofactor Regeneration ◽  
Chemoenzymatic Synthesis ◽  
One Pot ◽  
Enzymatic Reduction

A One-Pot Chemoenzymatic Synthesis of (2S,4R)-4-Methylproline Enables the First Total Synthesis of Antiviral Lipopeptide Cavinafungin B

2018 ◽  
Author(s):  
Christian R. Zwick ◽  
Hans Renata
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Complex Molecule ◽  
Molecular Target ◽  
Chemoenzymatic Synthesis ◽  
General Strategy ◽  
One Pot

We report an efficient ten-step synthesis of antiviral natural product cavinafungin B in 37% overall yield. By leveraging a one-pot chemoenzymatic synthesis of (2S,4R)-4-methylproline and oxazolidine-tethered (Rink-Boc-ATG-resin) SPPS methodology, the assembly of our molecular target could be conducted in an efficient manner.This general strategy could prove amenable to the construction of other natural and unnatural linear lipopeptides. The value of incorporating biocatalytic steps in complex molecule synthesis is highlighted by this work.

Studies on the synthesis of 2-acyl-1H-indenes via one-pot palladium-catalysed tandem Heck–aldol reaction

2010 ◽  
Vol 2010 (5) ◽  
pp. 254-258 ◽  
Author(s):  
Song Tu ◽  
Yong Sha ◽  
Long-He Xu ◽  
Zong-Yuan Xiao ◽  
Li-Yi Ye ◽  
...  
Keyword(s):  
Aldol Reaction ◽  
One Pot

One-Pot Chemoenzymatic Synthesis of 3‘-Functionalized Cephalosporines (Cefazolin) by Three Consecutive Biotransformations in Fully Aqueous Medium

1997 ◽  
Vol 62 (26) ◽  
pp. 9099-9106 ◽  
Author(s):  
O. H. Jústiz ◽  
R. Fernández-Lafuente ◽  
J. M. Guisán ◽  
P. Negri ◽  
G. Pagani ◽  
...  
Keyword(s):  
Aqueous Medium ◽  
Chemoenzymatic Synthesis ◽  
One Pot

One-Pot Approach for C-C Bond Formation through Ruthenium-Amido Complex Catalyzed Tandem Aldol Reaction/Hydrogenation

Synthesis ◽  
2010 ◽  
Vol 2010 (15) ◽  
pp. 2577-2582 ◽  
Author(s):  
Hong Liu ◽  
Haifeng Sun ◽  
Deju Ye ◽  
Hualiang Jiang ◽  
Kaixian Chen
Keyword(s):  
Bond Formation ◽  
Aldol Reaction ◽  
One Pot

One-Pot Approach to Chiral Chromenes via Enantioselective Organocatalytic Domino Oxa-Michael—Aldol Reaction.

ChemInform ◽  
2007 ◽  
Vol 38 (21) ◽  
Author(s):  
Hao Li ◽  
Jian Wang ◽  
Timiyin E-Nunu ◽  
Liansuo Zu ◽  
Wei Jiang ◽  
...  
Keyword(s):  
Aldol Reaction ◽  
One Pot
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