Influence of Piperine and Omeprazole on The Regional Absorption of Daclatasvir from Rabbit Intestine

2022 ◽  
Author(s):  
Shimaa M. Ashmawy ◽  
Dina A. Eltahan ◽  
Mohamed A. Osman ◽  
Ebtessam A. Essa
Keyword(s):  
Rabbit Intestine

scholarly journals Inhibition of Amino Acid Transport in Rabbit Intestine by p-Chloromercuriphenyl Sulfonic Acid

1973 ◽  
Vol 62 (2) ◽  
pp. 131-146 ◽  
Author(s):  
John F. Schaeffer ◽  
Robert L. Preston ◽  
Peter F. Curran
Keyword(s):  
Transport System ◽  
Conformational Changes ◽  
Marked Reduction ◽  
Sulfhydryl Group ◽  
Major Effect ◽  
Acid Transport ◽  
Michaelis Constant ◽  
Saturation Kinetics ◽  
Rabbit Intestine ◽  
Transport Site

Influx of phenylalanine across the brush border of rabbit intestine is markedly reduced by treatment with 5 mM p-chloromercuriphenyl sulfonate (PCMBS). The effect is rapidly and completely reversed by dithiothreitol. Phenylalanine influx into PCMBS-treated tissue can be competitively inhibited by other neutral amino acids and follows saturation kinetics. PCMBS causes an increase in the apparent Michaelis constant from the value observed in control tissue but does not alter the maximal influx significantly. Treatment of the tissue with PCMBS leads to a significant reduction in the Na-sensitivity of the transport, and a number of results indicate that the major effect of the reagent is to cause a marked reduction in the affinity of the transport system for Na. The transport system can be partially protected against reaction with PCMBS by phenylalanine and tryptophan but not by methionine or norleucine. The results suggest that PCMBS reacts with a sulfhydryl group in the region of the transport site and may alter conformational changes associated with the binding of substrates.

Evaluation of Different Antibiotics in Inhibiting Colonization of Vibrio cholerae O1 and O139 in the Rabbit Intestine

Chemotherapy ◽  
1998 ◽  
Vol 44 (2) ◽  
pp. 108-111 ◽  
Author(s):  
M.K. Chakrabarti ◽  
M.K. Bhattacharya ◽  
J. Bhattacharya ◽  
S.K. Bhattacharya ◽  
D. Mahalanabis
Keyword(s):  
Vibrio Cholerae ◽  
Rabbit Intestine ◽  
Vibrio Cholerae O1

Resting oxygenation of rat and rabbit intestine: arteriolar and capillary contributions

1995 ◽  
Vol 269 (4) ◽  
pp. H1342-H1348 ◽  
Author(s):  
H. G. Bohlen ◽  
J. M. Lash
Keyword(s):  
Small Intestine ◽  
Tissue Oxygenation ◽  
Second Order ◽  
Oxygen Exchange ◽  
Total Reduction ◽  
Arterial Blood ◽  
Rabbit Intestine ◽  
Counter Current ◽  
Vascular Region

Counter-current exchange of oxygen may occur between inflow and outflow microvessels of the small intestine and greatly influence the dominant sites of tissue oxygenation. To determine the location and magnitude of potential exchange, percent saturation of hemoglobin with oxygen (%SHb) was measured in microvessels throughout the intestine of rats and rabbits. Oxygen losses from systemic arterial blood through large and intermediate arterioles (second order, 2A) was 5-7%SHb in both species, and there was no evidence of an increase in percent saturation along intermediate and large venules. A larger loss of oxygen from arterioles and an increase in venous saturation would be evident if significant arteriolar to venular counter-current exchange of oxygen occurred in the submucosa. From 2A to the villus tip, arteriolar saturation decreased approximately 10%SHb in rabbits and approximately 15%SHb in rats; the villus tip percent saturation was 72.9 +/- 3.9%SHb in rabbits and 69.9 +/- 2.9%SHb in rats. An additional decrease of 5%SHb in rabbits and 15%SHb in rats occurred across the villus capillaries and smallest venules. Although the total reduction in percent saturation across the villi was different between the two species, 70-90% of the total arteriovenous oxygen losses occurred in the capillaries and small arterioles of the villi. We found no evidence of counter-current exchange of oxygen in villi or any other vascular region. Rather, as appears to occur in most organs, small arterioles in conjunction with capillaries dominate resting oxygen exchange to tissue.

The effect of bacterial enterotoxins implicated in sids on the rabbit intestine

Pathology ◽  
2001 ◽  
Vol 33 (2) ◽  
pp. 187-196 ◽  
Author(s):  
John Kamaras ◽  
William G. Murrell
Keyword(s):  
Rabbit Intestine

Unstirred Water Layers in Rabbit Intestine: Effects of Pectin

1984 ◽  
Vol 176 (2) ◽  
pp. 183-186 ◽  
Author(s):  
G. A. Gerencser ◽  
J. Cerda ◽  
C. Burgin ◽  
M. M. Baig ◽  
R. Guild
Keyword(s):  
Water Layers ◽  
Rabbit Intestine

Mutual interaction of prostaglandin-like material and noradrenaline during periarterial nerve stimulation of rabbit intestine

1983 ◽  
Vol 35 (10) ◽  
pp. 674-676 ◽  
Author(s):  
V. R. Dhumal ◽  
A. Girdhar ◽  
O. D. Gulati ◽  
K. G. Hemavathi ◽  
D. S. Shah
Keyword(s):  
Nerve Stimulation ◽  
Mutual Interaction ◽  
Rabbit Intestine ◽  
Stimulation Of

Comparison of methods for the determination of viability of ischemic rabbit intestine

1994 ◽  
Vol 9 (3) ◽  
Author(s):  
Xian-ping Liao ◽  
Ya-xiong She ◽  
Cheng-ren Shi ◽  
Zong-de Zhang ◽  
Min Li
Keyword(s):  
Comparison Of Methods ◽  
Rabbit Intestine
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