Optimization of juice production from “cempedak” (Artocarpus integer) fruit pulp liquefied with the aid of enzymes

PurposeThe purpose of this research is to produce “cempedak” juice using enzyme aided-liquefaction by examining the effects of enzyme types (Pectinex® Ultra SP-L, Celluclast® 1.5 L and Fungamyl® 800 L), enzyme concentrations (0–1.5% v/w), incubation time (0–2.5 h) and incubation temperature (35–60 °C) on juice yield and viscosity, total soluble solids and color of fruit puree.Design/methodology/approachRipe “cempedak” pulp from CH28 fruit was first pureed in a blender and then homogenized with water at 1:2 ratio. The diluted puree was then liquefied with the enzymes separately to reduce its viscosity. Analyses such as juice yield, viscosity, total soluble solids and color of the liquefied “cempedak” puree were then carried out.FindingsResults indicated that the optimized use of 1.2% (v/w) Celluclast® 1.5 L (Novozymes, Denmark), a cellulase preparation, at 45 °C and 1 h produced juice with the lowest viscosity (349.4 cP) and the highest juice yield (82.3% v/w). Liquefied “cempedak” juice was darker (with L* value of 51.17) and more yellowish (b* value of 38.88) compared to “cempedak” juice without liquefaction (control). When compared to untreated “cempedak” juice, the droplet size of “cempedak” juice obtained after liquefaction under optimized conditions was found to be lower, regardless of whether the juice was filtered (with a total reduction of 23% of droplet size) or not filtered (with a total reduction of 16% of droplet size). The results indicate the possibility of employing Celluclast® 1.5 L to produce “cempedak” juice that can be further processed such as for the production of “cempedak” fruit powder.Originality/valueThis paper provides information on the enzyme concentration, incubation time and temperature for liquefying “cempedak” pulp such that the liquefied material produced can be used as a base feed for spray-drying to produce “cempedak” fruit powder.

Numerical simulation of slab deformation process with different reduction values in vertical rolls of mill 2000 roughing stands

Perfection of rolled stock production processes at continuous wide-strip hot rolling mill (CWHRM) aimed at minimization of metal consumption, is an effective mean to decrease its cost. In the process of slabs rolling at CWHRM, the metal consumption is stipulated first of all by complicated workpiece forming in roughing stands during consecutive reduction by vertical and horizontal rolls. Results of the numerical study of slab deformation with different values of reduction in vertical rolls of roughing stands of mill 2000 are presented. The implementation of rolling process model based on application of DEFORM-3D program of finiteelement analysis described for evaluation of metal shifting from the edges of slab in the direction of the middle of the width. The convergence of the simulation results with the measurements data of workpiece forming during roughing rolling at Severstal mill 2000 was experimentally confirmed. It was found that an increase of reduction in vertical rolls has no significant effect on the metal shifting from a narrow edge to a wide one. Increase the total reduction in vertical rolls leads to an unfavorable stress-strain state of the edge region and the Cockcroft–Latham criterion rises by 20–30%. It was proposed to reduce the total reduction in the vertical rolls of the roughing stands of mill 2000 down to 40–50 mm. It was shown that increase of time of slab moving from the heating furnace to the scale breaker causes growth the Cockcroft-Latham criterion and does not affect the amount of metal shifting from a narrow face to a wide one. The proposed method of simulation the process of slab deformation in the roughing group of the mill 2000 proved by results of industrial rolling can to be used for further study of the effect of rolls profiling and forming of surface defects with the provision of minimal metal shifting onto a wide face.

Dehydroaromatization of methane over noble metal loaded Mo/H-ZSM-5 zeolite catalysts

Dehydroaromatization of methane (MDA) reaction was investigated over platinum modified Mo/H-ZSM-5 catalysts which were pre-carbided at 750 °C. The influence of platinum on the catalytic performance and product selectivity of Mo/H-ZSM-5 catalysts for the MDA reaction at 700 °C were studied. The presence of platinum led to a slight decrease in methane conversion from 7.5 to 4.2%. Aromatic selectivities above 90% were obtained with catalysts containing low platinum loadings (0.5 and 1.0 wt.%), with benzene being the most prominent product. A decrease in coke selectivity and coke deposits was noted with the platinum modified Mo/H-ZSM-5 zeolite catalysts. A comparative study was performed to compare platinum, palladium and ruthenium promoted Mo/H-ZSM-5 zeolite catalysts with un-promoted Mo/H-ZSM-5. The ruthenium promoted catalyst proved to be superior in catalytic performance, with a higher methane conversion obtained than that found for platinum promoted and palladium promoted Mo/H-ZSM-5 catalysts. Benzene selectivity of about 60% was obtained for ruthenium and palladium promoted Mo/H- ZSM-5 catalysts and the total aromatic selectivity was maintained at 90%. TGA results showed a total reduction of 50% by weight of carbon deposited on the promoted Mo/H-ZSM-5 catalyst. Graphic abstract

Does Alt-RAMEC protocol and facemask treatment affect dentoalveolar structures?

ABSTRACT Objectives To evaluate dentoalveolar changes immediately after the alternate rapid maxillary expansion and constriction (Alt-RAMEC) protocol and facemask (FM) treatment using cone-beam computed tomography images. Materials and Methods Cone-beam computed tomography images of 20 patients (mean age = 9.64 ± 1.3 years) who received the Alt-RAMEC protocol before FM treatment were retrieved in this retrospective study. Dental and alveolar inclinations, buccal and palatal alveolar bone thickness, and buccal and palatal alveolar bone height changes were measured before treatment (T0), after the Alt-RAMEC protocol (T1), and after FM treatment (T2). Measurements for right and left molars were performed separately. The Shapiro-Wilks test was used to assess the conformity of the parameters to the normal distribution. The paired t-test and repeated measures analysis of variance were used for normally distributed data. The Wilcoxon signed-rank test and Friedman test were used for non-normally distributed data. The Bonferroni correction was used to reduce the chances of obtaining false-positive results. Statistical significance was set at P < .05. Results Buccal alveolar bone thickness and alveolar bone inclinations decreased significantly from T1 to T0 and showed no significant change from T2 to T1. The total reduction T2-T0 was statistically significant. The change in palatal alveolar bone thickness was not significant T1-T0 but increased significantly for T2-T1 and T2-T0. Buccal alveolar bone height, palatal alveolar bone height, and molar inclinations increased significantly T1-T0, but there was no significant change T2-T1. The total reduction at T2-T0 was statistically significant. Conclusions The results of this study revealed that the effects of the Alt-RAMEC protocol on dentoalveolar tissues were similar to the changes reported in the literature after rapid palatal expansion.

Technological Shells in the Processes of Rolling Thin Sheets From Hard-To-Deform Materials

The present work is devoted to the study of deformability of high-strength and hard-to-deform materials. Today the most promising technology for their forming is a rolling in a ductile shell also known as sandwich rolling. Despite the fact that the use of such technological shells allows to effectively reduce the rolling forces and soften the stress state, they have not got wide application in manufacturing practice due to the accompanying disadvantages. On the basis of finite element (FE) simulation, we carried out an all-around analysis of the effect of shell material on process parameters of method: rolling force, total reduction of hard-to-deform material, deformation inhomogeneity and thickness variation of rolled sheet, stress state scheme. Analysis of computer models allowed us to highlight the main reason for the low efficiency of the known method and propose a new design of technological shells. Preliminary FE-simulation of the rolling process of hard-to-deform material in the new technological shells showed an improvement in process parameters and method efficiency. Approbation was carried out via rolling U12 high-carbon tool steel (Russian analogue of DIN C110W2 tool steel), which has low plasticity and high hardness, on the rolling mill Duo 250 under laboratory conditions. Evaluation according to technological criteria – reducing the rolling force, increase of the total reduction and the deformation uniformity of hard-to-deform material, improvement of its deformability – showed the prospects of using proposed technological shells in manufacturing practice.

PRODUCTIVITY OF PRODUCTION RESOURCES AS A FACTOR OF CONSTRUCTION ENTERPRISES’ PROFITABILITY IN UKRAINE

The article proposes a model of deterministic factor analysis, which allows to assess the impact on the profitability of all enterprise’s activities of the production resources’ productivity as well as indicators of the income’s and expenses’ structure of the enterprise. As a result of applying this model for factor analysis, it is possible to justify ways to increase the profitability of the enterprise in view of its various activities. The dynamics of profitability of all and operational activities in construction enterprises of Ukraine for 2010-2020 is analyzed. The comparison of these indicators with the corresponding indicators characterizing the average enterprise in the economy of Ukraine is made. The analysis of profitability of all construction enterprise’s activities in view of specificity for their basic activity and size is carried out. It was found that construction companies, with the exception of 2018 and 2019, operated inefficiently, receiving a net loss. Such financial results are much worse than the average enterprises’ results in Ukraine. Although operating activities were profitable, they did not reach the average values ​​in the Ukrainian economy. Enterprises engaged in the organization or direct construction of buildings and communications were the least efficient. Small businesses were more likely to suffer losses than large and medium-sized ones. On the basis of the model proposed in the article by the method of chain substitutions, a deterministic factor analysis of the profitability of all construction enterprises’ activities for 2014-2020 was carried out. It is established that the production resources’ productivity of this type of activity decreased annually during the analyzed period, except for 2016. The total reduction in production resources’ productivity was 0.216 UAH / UAH. It is concluded that this factor was a stable reserve for increasing profitability. It is concluded that in order to increase the profitability of all activities in construction enterprises of Ukraine, it is important to manage the production resources’ productivity.

Effect of the initial austenitization temperature on the structural microheterogeneity during drawing of carbon steel with a pearlite structure

During wire production, strain fields can be distributed inhomogeneously over the section during drawing and cause structural micro-inhomogeneity, which significantly affects the stability of the process. However, during plastic deformation of carbon steel with a pearlite structure, the interlamellar spacing in the ferrite-carbide mixture and the size of pearlite colonies, which determine the deformation behavior of steel, are of great importance. In addition, in the wire manufacturing technology, heat treatment operations are used with heating the steel to the austenitic state, the temperature of which significantly affects the formation of the structure and properties of the steel. The paper investigates the effect of the austenitization temperature on the structural microheterogeneity of a wire made of carbon steel with a pearlite structure after drawing. The results of studying the microstructure, determining the interlamellar spacing, the anisotropy coefficient of pearlite colonies, as well as the distribution of microhardness over the cross section of the sample during drawing after different temperatures of preliminary austenitization are presented. It is shown that after preliminary austenitization at temperatures of 900, 950 and 1000 °C in a wire made of carbon steel with a pearlite structure, microstructural inhomogeneity in the dispersion of the ferrite-pearlite mixture is observed. It manifests itself as a difference of the interlamellar spacing in pearlite at the surface and in the center of the sample cross section and is retained during subsequent drawing with a total reduction of 8 to 15%. It has been established that the temperature of preliminary austenitization has practically no effect on the anisotropy coeffi cient of pearlite colonies in the initial state after austenitization, and it does not change over the cross section of the sample. However, with subsequent drawing with an increase in the total reduction, the anisotropy coefficient increases, while it increases from the surface to the center of the sample. It is revealed that with an increase in the preliminary austenitization temperature from 900 to 1000 °C, the microstructural inhomogeneity in the drawn wire is manifested to a greater extent, which can be associated with an increase in the grain size of the initial austenite, the size of pearlite colonies, and the interlamellar spacing in pearlite. Microstructural inhomogeneity is confirmed by the nature of the distribution of microhardness over the cross section of the sample. The research was carried out with the financial support of the Russian Foundation for Basic Research and DNT within the framework of the scientific project No. 18-58-45008 IND_a.

Prediction of Therapeutic Outcome in a Naturalistic Setting Using Pretreatment Psychological Distress Indicators

Background: Outcome predictions allow to improve psychotherapy and to increase economic benefit. The efficient translation into practice requires simple prediction methods. The present study evaluates the prediction of treatment outcome based on initial distress level. Methods: Routine data of a university psychotherapy outpatient clinic were used (N = 3,145, Mage = 35.8, 67% female). Low versus high distress patients (classified by overall psychological distress, symptomatology, and previous treatment) were compared on total reduction in psychopathology, (early) response, remission, and premature treatment discontinuation using t tests and logistic regressions. Response and remission were assessed via relative (percentage improvement) and absolute measures (Reliable Change Index; RCI). Results: Distress level was inversely related to percentage improvement (OR = 0.62) and remission (OR = 0.34). It was positively related to total reduction in psychopathology (d = 0.63), RCI response (OR = 2.37), and treatment discontinuation (OR = 2.15). Early response and treatment discontinuation partially mediated the relationship between distress level and treatment outcome. Conclusions: Treatment success tends to be lower when initial distress is high, but this finding appears contingent on the operationalization of treatment outcome. The presented classification approach is easy to implement in practice and may be useful in order to counter an excessive workload in psychotherapy trainees.

USG GUIDED PERCUTANEOUS NEEDLE APIRATION VERSUS USG GUIDED PIGTAIL CATHETER DRAINAGE IN THE MANAGEMENT OF LIVER ABSCESS - A PROSPECTIVE RANDOMISED CONTROLLED STUDY

Background: The aim of this study was to determine and compare the therapeutic effectiveness and safety of USG guided percutaneous continuous catheter drainage and USG guided percutaneous needle aspiration in the treatment of liver abscess in Trichy. Methods: This is a prospective randomised comparative study of 50 patients, presented in outpatient and emergency department at the hospital, randomised equally into two groups, percutaneous needle aspiration and pigtail catheter drainage. The effectiveness of their treatment was measured in terms of duration of hospital stay, time taken for improvement of clinical symptoms, time taken for 50% reduction in cavity size and total or near total reduction of abscess cavity. Independent t-test was used to analyse these parameters. Results: The success rate was significantly better in catheter drainage group. Patients in pigtail catheter drainage group showed earlier clinical improvement (p 0.000) and 50% reduction in abscess cavity volume (p 0.000) and near total reduction of abscess cavity was earlier (p 0.019) as compared to those who underwent percutaneous needle aspiration. Conclusion: Our study concludes that percutaneous catheter drainage is a better modality as compared to percutaneous needle aspiration in respect to clinical improvement, reduction of cavity and success rate.

Sympathetic renal denervation treatment in resistant hypertension: one-year follow-up

Aims A comparison influence of renal denervation versus pharmacological treatment with sympathetic nervous system blockers on blood pressure in patients with resistant hypertension. Methods 125 patients with resistant hypertension without comorbidities after a 3-week standardized treatment with Losartan 100 mg, Amlodipine 10 mg and Indapamid 1,5 mg and confirmation of their resistance were randomly assigned into three groups, depending on medication supplemented to previously administered: IM group – selective I1-imidazoline agonist Moxonidine, IIB group – cardioselective beta-blocker Bisoprolol and IIID group – renal artery denervation. Patients were assessed by ambulatory blood pressure monitoring at baseline, 3, 6 and 12 month follow-up. The compliance to drug treatment was confirmed by 8-item Morisky Medication Adherence Scale. Renal denervation was performed with a Symplicity Spyral catheter. Results The mean 24 hour systolic blood pressure (SBP m/24 h) at baseline were 179.0±2.02 mmHg in IM group versus 177.96±2.44 mmHg in IIB group and 176.92±1.97 mmHg in IIID group, p>0.05. Statistically significant dynamics was recorded starting with 3 months of evaluation in all three groups, the group of patients undergoing denervation of the renal arteries demonstrating a net superior effect compared with pharmacological treatment: −6.48±0.81 mmHg in I M group versus −6.2±0.88 mmHg in II B group and −23.28±1.9 mmHg in III D group, p<0.001. The beneficial effect was maintained until the end of the study, when in observational group supplemented with Moxonidine SBP m/24 h were 159.6±1.72 mmHg with a total reduction of −19.9±0.7 mmHg from baseline, in Bisoprolol group −164.08±1.93 mmHg with a reduction of −13.88±1.13 mmHg and 141.76±0.77 mmHg in renal denervation group with a total reduction of −35.16±2.23 mmHg, p<0.001. The mean 24 hour diastolic blood pressure (DBP m/24 h) increased at baseline in all three groups (105.52±1.28 mmHg in IM versus 108.6±1.6 mmHg in IIB and 107.24±0.92 mmHg in IIID, p>0.05) similar to SBP m/24 h noted a significantly reduction at 3 month follow-up: −4.8±0.96 mmHg in IM group versus −3.64±0.47 mmHg in IIB group and −12.08±0.63 mmHg in IIID group, p<0.001. The maximum reduction in DBP m/24 h were registered at 12 month follow-up, a comparative analyses of dynamics between groups showing a presence of statistical difference due to superiority of renal denervation treatment in amelioration of this parameter: −13.68±0.83 mmHg in IM group versus −10.72±0.64 mmHg in IIB group and −20.2±1.28 mmHg in IIID group, p<0.001. Conclusions The application of all three treatment regimens has been shown to be effective in reducing SBP and DBP values m/24 hours in patients with resistant hypertension, with a superior but comparable effect of Moxonidine to Bisoprolol and the absolute superiority of renal denervation treatment versus both pharmacological treatment regimens. Funding Acknowledgement Type of funding source: None