Folic acid antagonist use before and during pregnancy and risk for selected birth defects

2020 ◽  
Vol 112 (18) ◽  
pp. 1526-1540
Author(s):  
Stephen M. Kerr ◽  
Samantha E. Parker ◽  
Allen A. Mitchell ◽  
Sarah C. Tinker ◽  
Martha M. Werler
Keyword(s):  
Folic Acid ◽  
Birth Defects ◽  
Folic Acid Antagonist ◽  
Acid Antagonist

The Use of Methotrexate in Rheumatoid Arthritis

1985 ◽  
Vol 19 (5) ◽  
pp. 349-358 ◽  
Author(s):  
Peter W. Letendre ◽  
Douglas J. DeJong ◽  
Donald R. Miller
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Trials ◽  
Folic Acid ◽  
Side Effects ◽  
Adverse Effects ◽  
Systemic Administration ◽  
Refractory Disease ◽  
Controlled Clinical Trials ◽  
Folic Acid Antagonist ◽  
Acid Antagonist

The use of methotrexate in rheumatoid arthritis is reviewed. Methotrexate, a folic acid antagonist, is sometimes employed in an attempt to symptomatically control patients whose disease does not respond adequately to conventional therapies. Systemic administration of 7.5–15 mg/wk in a “pulse” fashion appears to be effective without precipitating severe adverse effects. However, concern over potentially serious side effects and a lack of well-controlled clinical trials have limited its use to severe, refractory disease. Further studies are needed before its role in rheumatoid arthritis can justifiably be expanded.

Precipitation of Menstrual Bleeding in Monkeys by a Folic Acid Antagonist

Science ◽  
1950 ◽  
Vol 112 (2901) ◽  
pp. 147-147 ◽  
Author(s):  
M. X. Zarrow ◽  
F. L. Hisaw ◽  
H. A. Salhanick
Keyword(s):  
Folic Acid ◽  
Menstrual Bleeding ◽  
Folic Acid Antagonist ◽  
Acid Antagonist

scholarly journals DIFFERING POLYAMINE RESPONSES DURING TERATOGENESIS WITH DIPHENYLHYDANTOIN AND FOLIC ACID ANTAGONIST

1977 ◽  
Vol 11 (4) ◽  
pp. 528-528
Author(s):  
Michael L Netzloff ◽  
Jaime L Frias ◽  
Owen M Rennert
Keyword(s):  
Folic Acid ◽  
Folic Acid Antagonist ◽  
Acid Antagonist
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