FAILURE OF FOLIC ACID ANTAGONIST TO INTERFERE WITH THE ACTION OF TESTOSTERONE PROPIONATE ON THE COMBS AND TESTES OF YOUNG COCKERELS1

Endocrinology ◽  
1951 ◽  
Vol 48 (2) ◽  
pp. 125-132 ◽  
Author(s):  
M. X. ZARROW ◽  
I. B. KORETSKY ◽  
I. G. ZARROW
1985 ◽  
Vol 19 (5) ◽  
pp. 349-358 ◽  
Author(s):  
Peter W. Letendre ◽  
Douglas J. DeJong ◽  
Donald R. Miller

The use of methotrexate in rheumatoid arthritis is reviewed. Methotrexate, a folic acid antagonist, is sometimes employed in an attempt to symptomatically control patients whose disease does not respond adequately to conventional therapies. Systemic administration of 7.5–15 mg/wk in a “pulse” fashion appears to be effective without precipitating severe adverse effects. However, concern over potentially serious side effects and a lack of well-controlled clinical trials have limited its use to severe, refractory disease. Further studies are needed before its role in rheumatoid arthritis can justifiably be expanded.


2020 ◽  
Vol 112 (18) ◽  
pp. 1526-1540
Author(s):  
Stephen M. Kerr ◽  
Samantha E. Parker ◽  
Allen A. Mitchell ◽  
Sarah C. Tinker ◽  
Martha M. Werler

Science ◽  
1950 ◽  
Vol 112 (2901) ◽  
pp. 147-147 ◽  
Author(s):  
M. X. Zarrow ◽  
F. L. Hisaw ◽  
H. A. Salhanick

1977 ◽  
Vol 11 (4) ◽  
pp. 528-528
Author(s):  
Michael L Netzloff ◽  
Jaime L Frias ◽  
Owen M Rennert

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