Decreasing rumination using a starchy food satiation procedure

2002 ◽  
Vol 17 (1) ◽  
pp. 21-29 ◽  
Author(s):  
Laura L. Dudley ◽  
Cammarie Johnson ◽  
R. Scott Barnes
Keyword(s):  

2021 ◽  
Vol 7 (22) ◽  
pp. eabf8719
Author(s):  
Yong Han ◽  
Guobin Xia ◽  
Yanlin He ◽  
Yang He ◽  
Monica Farias ◽  
...  

The neural circuitry mechanism that underlies dopaminergic (DA) control of innate feeding behavior is largely uncharacterized. Here, we identified a subpopulation of DA neurons situated in the caudal ventral tegmental area (cVTA) directly innervating DRD1-expressing neurons within the lateral parabrachial nucleus (LPBN). This neural circuit potently suppresses food intake via enhanced satiation response. Notably, this cohort of DAcVTA neurons is activated immediately before the cessation of each feeding bout. Acute inhibition of these DA neurons before bout termination substantially suppresses satiety and prolongs the consummatory feeding. Activation of postsynaptic DRD1LPBN neurons inhibits feeding, whereas genetic deletion of Drd1 within the LPBN causes robust increase in food intake and subsequent weight gain. Furthermore, the DRD1LPBN signaling manifests the central mechanism in methylphenidate-induced hypophagia. In conclusion, our study illuminates a hindbrain DAergic circuit that controls feeding through dynamic regulation in satiety response and meal structure.





Author(s):  
S. Thammathongchat ◽  
M. Fukuoka ◽  
T. Hagiwara ◽  
T. Sakiyama ◽  
H. Watanabe
Keyword(s):  


1994 ◽  
Vol 73 (3) ◽  
pp. 652-660 ◽  
Author(s):  
P. Lingstrom ◽  
D. Birkhed ◽  
J. Ruben ◽  
J. Arends


2018 ◽  
Vol 83 ◽  
pp. 454-464 ◽  
Author(s):  
Jing Ai ◽  
Torsten Witt ◽  
Gary Cowin ◽  
Sushil Dhital ◽  
Mark S. Turner ◽  
...  


Fuel ◽  
2019 ◽  
Vol 253 ◽  
pp. 1556-1564 ◽  
Author(s):  
Jingchun Huang ◽  
Yu Qiao ◽  
Xianfeng Wei ◽  
Juntong Zhou ◽  
Yun Yu ◽  
...  


1983 ◽  
Vol 4 (6) ◽  
pp. 469-471 ◽  
Author(s):  
Charles W. Stratton ◽  
Rosemary Verrall

Serratia marcescens has an interesting and many-faceted history. The presence of the red pigmented organism on starchy food products long had been noted and was thought to be blood; its presence on consecrated wafers was thought to be the blood of Christ. It was not until 1819 that Bizio, a pharmacist, demonstrated that a microorganism was responsible for the red pigment. He named this microorganism Serratia marcescens; Serratia in honor of Serafino Serrati, an Italian physicist who invented the steamboat and marcescens from the Latin, “to decay.”Because of the pigment production and because Serratia marcescens was believed to be a benign, saprophytic organism, it was used widely as a biological marker from 1906 to 1968. This use has been controversial in regard to experiments conducted by the US Army involving biological warfare techniques. In addition, the recognition in the 1950s of the ability of this organism to cause nosocomial infections has curtailed its use as a biological marker. Serratia marcescens is now recognized as a cause of serious infections in man. It has been implicated in practically every kind of infection and is a particularly serious problem with nosocomial infections.



2000 ◽  
Vol 357-358 ◽  
pp. 57-63 ◽  
Author(s):  
Poonam Aggarwal ◽  
David Dollimore


2015 ◽  
Vol 281 ◽  
pp. 131-136 ◽  
Author(s):  
Kathy J. Dickinson ◽  
Marcy L. Wainwright ◽  
Riccardo Mozzachiodi


1998 ◽  
Vol 46 (5) ◽  
pp. 461 ◽  
Author(s):  
Steven S. Comport ◽  
Ian D. Hume

Gut morphology and rate of digesta passage through the gut in captive giant white-tailed rats (Uromys caudimaculatus) were investigated. Rate of passage was measured using a solute marker (Co-EDTA), a marker of large particles (Cr-mordanted plant cell walls) and spores of the ectomycorrhizal fungus Pisolithus spp. The mean retention time (MRT) of fungal spores in the whole gut (48.4 ± 6.0 h), was long in comparison to that found in other rodents of similar body mass and was intermediate to MRT of the solute marker (45.4 ± 8.8 h) and the large particle marker (55.5 ± 7.2 h). Thus, retention of spores is likely to be little affected by being free or attached to pieces of ingested fruiting bodies. The stomach is unilocular and hemiglandular and contains a large fundic diverticulum lined entirely by non-glandular squamous epithelium. The significantly longer MRT for the large particle marker than the solute marker suggests that some selective retention of particles takes place, probably in the fundic diverticulum of the stomach. We suggest that the large fundic diverticulum may function in storage and possibly increased digestive efficiency of starchy food items, and in retaining spores, especially when still attached to fruiting bodies.



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