Prooxidant action of carazolol in the Fenton-like reaction

Luminescence ◽  
2010 ◽  
Vol 26 (6) ◽  
pp. 429-433 ◽  
Author(s):  
Irena Kruk ◽  
Teresa Michalska ◽  
Aleksandra Kładna ◽  
Hassan Y. Aboul-Enein
Keyword(s):  
Prooxidant Action

Increased prooxidant action of hepatic cytosolic low-molecular-weight iron in experimental iron overload

Hepatology ◽  
1990 ◽  
Vol 11 (6) ◽  
pp. 1038-1043 ◽  
Author(s):  
Robert S. Britton ◽  
Marco Ferrali ◽  
Christopher J. Magiera ◽  
Richard O. Recknagel ◽  
Bruce R. Bacon
Keyword(s):  
Molecular Weight ◽  
Iron Overload ◽  
Low Molecular Weight ◽  
Prooxidant Action ◽  
Low Molecular Weight Iron

scholarly journals Quality, Microstructure, and Technological Properties ofSheepMeat Marinated in Three Different Ways

2017 ◽  
Vol 2017 ◽  
pp. 1-10
Author(s):  
Dessislava Borislavova Vlahova-Vangelova ◽  
Stefan Georgiev Dragoev ◽  
Dessislav Kostadinov Balev ◽  
Bahytkul Kajkenovna Assenova ◽  
Kumarbek Junusbekovich Amirhanov
Keyword(s):  
Protein Solubility ◽  
Amino Nitrogen ◽  
Sodium Lactate ◽  
Technological Properties ◽  
Lipid Fractions ◽  
Sds Page ◽  
Lipid And Protein Oxidation ◽  
Oil Emulsions ◽  
Prooxidant Action ◽  
Page Electrophoresis

The objective of this study was to explore the effect of 24 and 48 h alkaline (2% pentasodium tripolyphosphate), acid (2% sodium lactate), and water-oil marinating (water : sun flavor oil = 1 : 1 and 2% salt) as well as brine soaking (2% salt) on microstructure, changes in protein, and lipid fractions and technological properties of sheep (m. Longissimus dorsi). Strong myofibrillar fragmentation after 48 h alkaline marinating was observed. Significant swelling and increasing of spaces between myofibrils were found after 24 h brine soaking. Marinating in water-oil emulsions did not show a significant impact on the muscle microstructure. Alkaline and acid marinating as well as salt soaking promote the myofibrillar protein solubility and increased the free amino nitrogen content. After 24 h acid and 48 h alkaline marinating SDS-PAGE electrophoresis showed increasing of 25–30 kDa protein bands. The results obtained for the lipid and protein oxidation confirm prooxidant action of the sodium lactate (2%) and antioxidant effect of polyphosphates (2%) in marinated sheep.

Prooxidant action of desferrioxamine: Fenton-like production of hydroxyl radicals by reduced ferrioxamine

1986 ◽  
Vol 2 (4) ◽  
pp. 237-243 ◽  
Author(s):  
Donald C. Borg ◽  
Karen M. Schaich
Keyword(s):  
Hydroxyl Radicals ◽  
Prooxidant Action

Prooxidant action of gallic acid compounds: copper-dependent strand breaks and the formation of 8-hydroxy-2′-deoxyguanosine in DNA

2002 ◽  
Vol 16 (6) ◽  
pp. 705-709 ◽  
Author(s):  
M Yoshino ◽  
M Haneda ◽  
M Naruse ◽  
H.H Htay ◽  
S Iwata ◽  
...  
Keyword(s):  
Gallic Acid ◽  
Strand Breaks ◽  
Prooxidant Action

Antioxidant vs. prooxidant action of phenothiazine in a biological environment in the presence of hydroxyl and hydroperoxyl radicals: a quantum chemistry study

RSC Advances ◽  
2015 ◽  
Vol 5 (19) ◽  
pp. 14678-14689 ◽  
Author(s):  
C. Iuga ◽  
A. Campero ◽  
A. Vivier-Bunge
Keyword(s):  
Aqueous Solution ◽  
Quantum Chemistry ◽  
Biological Environment ◽  
Prooxidant Action

In aqueous solution, phenothiazine regenerates and acts as an excellent antioxidant while in lipid media, it behaves as a prooxidant.

The design of redox active thiol peroxidase mimics: Dihydrolipoic acid recognition correlates with cytotoxicity and prooxidant action

2016 ◽  
Vol 104 ◽  
pp. 19-28 ◽  
Author(s):  
B. Zadehvakili ◽  
S.M. McNeill ◽  
J.P. Fawcett ◽  
G.I. Giles
Keyword(s):  
Dihydrolipoic Acid ◽  
Redox Active ◽  
Peroxidase Mimics ◽  
Thiol Peroxidase ◽  
Prooxidant Action

scholarly journals Bixin and Norbixin Have Opposite Effects on Glycemia, Lipidemia, and Oxidative Stress in Streptozotocin-Induced Diabetic Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Miguel Roehrs ◽  
Cassieli Gehlen Figueiredo ◽  
Mariane Magalhães Zanchi ◽  
Guilherme Vargas Bochi ◽  
Rafael Noal Moresco ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Protein Oxidation ◽  
Ldl Cholesterol ◽  
Diabetic Rats ◽  
Lipid Profiles ◽  
Water Soluble ◽  
Glucose Levels ◽  
Prooxidant Action ◽  
And Oxidative Stress

The present study investigated the effects of oral administration of annatto carotenoids (bixin (BIX) and norbixin (NBIX)) on glucose levels, lipid profiles, and oxidative stress parameters in streptozotocin (STZ)-induced diabetic rats. Animals were treated for 30 days in the following groups: nondiabetic control, diabetic vehicle, diabetic 10 mg/kg BIX, diabetic 100 mg/kg BIX, diabetic 10 mg/kg NBIX, diabetic 100 mg/kg NBIX, diabetic metformin, and diabetic insulin. Blood glucose, LDL cholesterol, and triglyceride levels were reduced in the diabetic rats treated with BIX. BIX treatment prevented protein oxidation and nitric oxide production and restored superoxide dismutase activity. NBIX treatment did not change most parameters assessed, and at the highest dose, it increased LDL cholesterol and triglycerides levels and showed prooxidant action (increased protein oxidation and nitric oxide levels). These findings suggested that BIX could have an antihyperglycemic effect, improve lipid profiles, and protect against damage induced by oxidative stress in the diabetic state. Because NBIX is a water-soluble analog of BIX, we propose that lipophilicity is crucial for the protective effect of annatto carotenoids against streptozotocin-induced diabetes.

scholarly journals Correlation between mammalian cell cytotoxicity of flavonoids and the redox potential of phenoxyl radical/phenol couple.

2012 ◽  
Vol 59 (2) ◽  
Author(s):  
Audronė Marozienė ◽  
Aušra Nemeikaitė-Čėnienė ◽  
Regina Vidžiūnaitė ◽  
Narimantas Čėnas
Keyword(s):  
Redox Potential ◽  
Bovine Leukemia Virus ◽  
Mammalian Cells ◽  
Leukemia Virus ◽  
Phenoxyl Radical ◽  
Oxidation Products ◽  
Redox Potentials ◽  
Oxidative Demethylation ◽  
Prooxidant Action ◽  
Main Factor

Flavonoids exhibit prooxidant cytotoxicity in mammalian cells due to the formation of free radicals and oxidation products possessing quinone or quinomethide structure. However, it is unclear how the cytotoxicity of flavonoids depends on the ease of their single-electron oxidation in aqueous medium, i.e., the redox potential of the phenoxyl radical/phenol couple. We verified the previously calculated redox potentials for several flavonoids according to their rates of reduction of cytochrome c and ferricyanide, and proposed experimentally-based values of redox potentials for myricetin, fisetin, morin, kaempferol, galangin, and naringenin. We found that the cytotoxicity of flavonoids (n=10) in bovine leukemia virus-transformed lamb kidney fibroblasts (line FLK) and murine hepatoma (line MH-22a) increases with a decrease in their redox potential of the phenoxyl radical/phenol couple and an increase in their lipophilicity. Their cytotoxicity was decreased by antioxidants and inhibitors of cytochromes P-450, α-naphthoflavone and isoniazide, and increased by an inhibitor of catechol-O-methyltransferase, 3,5-dinitrocatechol. It shows that although the prooxidant action of flavonoids may be the main factor in their cytotoxicity, the hydroxylation and oxidative demethylation by cytochromes P-450 and O-methylation by catechol-O-methyltransferase can significantly modulate the cytotoxicity of the parent compounds.

Effect of hydroxy substituent on the prooxidant action of naphthoquinone compounds

2010 ◽  
Vol 24 (3) ◽  
pp. 905-909 ◽  
Author(s):  
Keiko Murakami ◽  
Miyako Haneda ◽  
Shouko Iwata ◽  
Masataka Yoshino
Keyword(s):  
Prooxidant Action

Antioxidant and prooxidant action of nitric oxide donors and metabolites

BIOPHYSICS ◽  
2007 ◽  
Vol 52 (3) ◽  
pp. 315-321 ◽  
Author(s):  
L. L. Gudkov ◽  
K. B. Shumaev ◽  
E. I. Kalenikova ◽  
S. A. Gubkina ◽  
A. F. Vanin ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Donors ◽  
Prooxidant Action
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