Humanization of anti-human insulin receptor antibody for drug targeting across the human blood–brain barrier

Biotechnology and Bioengineering ◽

10.1002/bit.21120 ◽

2006 ◽

Vol 96 (2) ◽

pp. 381-391 ◽

Author(s):

Ruben J. Boado ◽

Yufeng Zhang ◽

Yun Zhang ◽

William M. Pardridge

Keyword(s):

Insulin Receptor ◽

Blood Brain Barrier ◽

Human Insulin ◽

Human Blood ◽

Drug Targeting ◽

Brain Barrier ◽

Receptor Antibody ◽

Blood Brain ◽

Human Insulin Receptor

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Drug targeting of a peptide radiopharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor.

Journal of Clinical Investigation ◽

10.1172/jci119708 ◽

1997 ◽

Vol 100 (7) ◽

pp. 1804-1812 ◽

Author(s):

D Wu ◽

J Yang ◽

W M Pardridge

Keyword(s):

Monoclonal Antibody ◽

Insulin Receptor ◽

Blood Brain Barrier ◽

Human Insulin ◽

Drug Targeting ◽

Brain Barrier ◽

Blood Brain ◽

Human Insulin Receptor

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Insulin Receptor Antibody−α-N-Acetylglucosaminidase Fusion Protein Penetrates the Primate Blood–Brain Barrier and Reduces Glycosoaminoglycans in Sanfilippo Type B Fibroblasts

Molecular Pharmaceutics ◽

10.1021/acs.molpharmaceut.6b00037 ◽

2016 ◽

Vol 13 (4) ◽

pp. 1385-1392 ◽

Author(s):

Ruben J. Boado ◽

Jeff Zhiqiang Lu ◽

Eric Ka-Wai Hui ◽

Huilan Lin ◽

William M. Pardridge

Keyword(s):

Fusion Protein ◽

Insulin Receptor ◽

Blood Brain Barrier ◽

Brain Barrier ◽

Type B ◽

Receptor Antibody ◽

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Insulin Receptor Antibody–Sulfamidase Fusion Protein Penetrates the Primate Blood–Brain Barrier and Reduces Glycosoaminoglycans in Sanfilippo Type A Cells

Molecular Pharmaceutics ◽

10.1021/mp500258p ◽

2014 ◽

Vol 11 (8) ◽

pp. 2928-2934 ◽

Author(s):

Ruben J. Boado ◽

Jeff Zhiqiang Lu ◽

Eric Ka-Wai Hui ◽

William M. Pardridge

Keyword(s):

Fusion Protein ◽

Insulin Receptor ◽

Blood Brain Barrier ◽

Type A ◽

Brain Barrier ◽

Receptor Antibody ◽

Blood Brain ◽

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Human Blood?Brain Barrier Insulin Receptor

Journal of Neurochemistry ◽

10.1111/j.1471-4159.1985.tb07167.x ◽

1985 ◽

Vol 44 (6) ◽

pp. 1771-1778 ◽

Author(s):

William M. Pardridge ◽

Jody Eisenberg ◽

Jing Yang

Keyword(s):

Insulin Receptor ◽

Blood Brain Barrier ◽

Human Blood ◽

Brain Barrier ◽

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Faculty Opinions recommendation of Reconstruction of the human blood-brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.738105264.793575662 ◽

2020 ◽

Author(s):

Dan Rujescu ◽

Matthias Jung

Keyword(s):

Blood Brain Barrier ◽

Human Blood ◽

Pathogenic Mechanism ◽

Brain Barrier ◽

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What human blood-brain barrier models can tell us about BBB function and drug discovery?

Expert Opinion on Drug Discovery ◽

10.1080/17460441.2019.1646722 ◽

2019 ◽

Vol 14 (11) ◽

pp. 1113-1123 ◽

Author(s):

Lino Ferreira

Keyword(s):

Drug Discovery ◽

Blood Brain Barrier ◽

Human Blood ◽

Brain Barrier ◽

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Phenylalanine transport at the human blood-brain barrier. Studies with isolated human brain capillaries.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)84595-7 ◽

1986 ◽

Vol 261 (14) ◽

pp. 6536-6541

Author(s):

T B Choi ◽

W M Pardridge

Keyword(s):

Human Brain ◽

Blood Brain Barrier ◽

Human Blood ◽

Brain Barrier ◽

Brain Capillaries ◽

Blood Brain ◽

Phenylalanine Transport

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Anti-drug antibody response in mucopolysaccharidosis type I patients treated with AGT-181, a brain penetrating human insulin receptor antibody-iduronidase fusion protein

Molecular Genetics and Metabolism ◽

10.1016/j.ymgme.2017.12.343 ◽

2018 ◽

Vol 123 (2) ◽

pp. S126 ◽

Author(s):

Mathias Schmidt ◽

Ruben J. Boado ◽

Roberto Giugliani ◽

William M. Pardridge

Keyword(s):

Antibody Response ◽

Fusion Protein ◽

Insulin Receptor ◽

Human Insulin ◽

Type I ◽

Mucopolysaccharidosis Type ◽

Mucopolysaccharidosis Type I ◽

Receptor Antibody ◽

Human Insulin Receptor

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The expression pattern of transporters and receptors regulating the efflux of amyloid β across human blood-brain barrier

Journal of the Neurological Sciences ◽

10.1016/j.jns.2017.08.2191 ◽

2017 ◽

Vol 381 ◽

pp. 776

Author(s):

Y. Sano ◽

F. Shimizu ◽

I. Eri ◽

Y. Takeshita ◽

T. Kanda

Keyword(s):

Expression Pattern ◽

Blood Brain Barrier ◽

Human Blood ◽

Brain Barrier ◽

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Quantitative and Mechanistic Understanding of AZD1775 Penetration across Human Blood–Brain Barrier in Glioblastoma Patients Using an IVIVE–PBPK Modeling Approach

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-17-0983 ◽

2017 ◽

Vol 23 (24) ◽

pp. 7454-7466 ◽

Author(s):

Jing Li ◽

Jianmei Wu ◽

Xun Bao ◽

Norissa Honea ◽

Youming Xie ◽

...

Keyword(s):

Blood Brain Barrier ◽

Human Blood ◽

Brain Barrier ◽

Pbpk Modeling ◽

Modeling Approach ◽

Blood Brain ◽

Mechanistic Understanding

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