scholarly journals Resemblance of the human liver sinusoid in a fluidic device with biomedical and pharmaceutical applications

2018 ◽  
Vol 115 (10) ◽  
pp. 2585-2594 ◽  
Author(s):  
Martí Ortega‐Ribera ◽  
Anabel Fernández‐Iglesias ◽  
Xavi Illa ◽  
Ana Moya ◽  
Víctor Molina ◽  
...  
Keyword(s):  
Human Liver ◽  
Liver Sinusoid ◽  
Pharmaceutical Applications ◽  
Fluidic Device

scholarly journals Monocyte-induced recovery of inflammation-associated hepatocellular dysfunction in a biochip-based human liver model

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Marko Gröger ◽  
Knut Rennert ◽  
Benjamin Giszas ◽  
Elisabeth Weiß ◽  
Julia Dinger ◽  
...  
Keyword(s):  
Liver Dysfunction ◽  
Human Liver ◽  
Immune Cell ◽  
Early Event ◽  
Liver Sinusoid ◽  
Human Sepsis ◽  
Cellular Events ◽  
Cell Layers ◽  
Parenchymal Cells

Abstract Liver dysfunction is an early event in sepsis-related multi-organ failure. We here report the establishment and characterization of a microfluidically supported in vitro organoid model of the human liver sinusoid. The liver organoid is composed of vascular and hepatocyte cell layers integrating non-parenchymal cells closely reflecting tissue architecture and enables physiological cross-communication in a bio-inspired fashion. Inflammation-associated liver dysfunction was mimicked by stimulation with various agonists of toll-like receptors. TLR-stimulation induced the release of pro- and anti-inflammatory cytokines and diminished expression of endothelial VE-cadherin, hepatic MRP-2 transporter and apolipoprotein B (ApoB), resulting in an inflammation-related endothelial barrier disruption and hepatocellular dysfunction in the liver organoid. However, interaction of the liver organoid with human monocytes attenuated inflammation-related cell responses and restored MRP-2 transporter activity, ApoB expression and albumin/urea production. The cellular events observed in the liver organoid closely resembled pathophysiological responses in the well-established sepsis model of peritoneal contamination and infection (PCI) in mice and clinical observations in human sepsis. We therefore conclude that this human liver organoid model is a valuable tool to investigate sepsis-related liver dysfunction and subsequent immune cell-related tissue repair/remodeling processes.

scholarly journals Human Liver Sinusoid on a Chip for Hepatitis B Virus Replication Study

Micromachines ◽  
2017 ◽  
Vol 8 (1) ◽  
pp. 27 ◽  
Author(s):  
Young Kang ◽  
Siddhartha Rawat ◽  
Nicholas Duchemin ◽  
Michael Bouchard ◽  
Moses Noh
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Virus Replication ◽  
Human Liver ◽  
Replication Study ◽  
Liver Sinusoid ◽  
B Virus

scholarly journals Long-term maintenance of a microfluidic 3D human liver sinusoid

2015 ◽  
Vol 113 (1) ◽  
pp. 241-246 ◽  
Author(s):  
Ljupcho Prodanov ◽  
Rohit Jindal ◽  
Shyam Sundhar Bale ◽  
Manjunath Hegde ◽  
William J. McCarty ◽  
...  
Keyword(s):  
Human Liver ◽  
Liver Sinusoid ◽  
Term Maintenance

scholarly journals Primary cultures of endothelial cells from the human liver sinusoid are permissive for human immunodeficiency virus type 1.

1992 ◽  
Vol 89 (5) ◽  
pp. 1582-1586 ◽  
Author(s):  
A. M. Steffan ◽  
M. E. Lafon ◽  
J. L. Gendrault ◽  
C. Schweitzer ◽  
C. Royer ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Endothelial Cells ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Human Liver ◽  
Primary Cultures ◽  
Liver Sinusoid ◽  
Immunodeficiency Virus

Deactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes

Xenobiotica ◽  
2009 ◽  
Vol 00 (00) ◽  
pp. 090901052053001-8
Author(s):  
K. Murai ◽  
H. Yamazaki ◽  
K. Nakagawa ◽  
R. Kawai ◽  
T. Kamataki
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Cytochrome P450 2A6

Author response for "Human liver‐derived MAIT cells differ from blood MAIT cells in their metabolism and response to TCR‐independent activation"

2020 ◽  
Author(s):  
Rajesh Lamichhane ◽  
Fran Munro ◽  
Thomas W. R. Harrop ◽  
Sara M. Harpe ◽  
Peter K. Dearden ◽  
...  
Keyword(s):  
Human Liver ◽  
Author Response ◽  
Mait Cells

Selegiline Metabolism and Cytochrome P450 Enzymes:In vitro Study in Human Liver Microsomes*

2000 ◽  
Vol 86 (5) ◽  
pp. 215-221 ◽  
Author(s):  
Paivi Taavitsainen ◽  
Markku Anttila ◽  
Leena Nyman ◽  
Hari Karnani ◽  
Jarmo S. Salonen ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Vitro Study

Human Liver Cocaine Carboxylesterases

1997 ◽  
Author(s):  
William F. Bosron ◽  
Robert A. Dean ◽  
Monica R. Brzezinski ◽  
Evgenia V. Pindel
Keyword(s):  
Human Liver
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